Agency: Cordis | Branch: FP7 | Program: CSA-CA | Phase: Fission-2013-5.1.1 | Award Amount: 1.86M | Year: 2013
Medical exposures for radiological examinations represent the highest and fastest growing contribution to manmade radiation exposure in the EU underlying the need for medical physics experts (MPEs), regulators and scientists in industry to bring in new research results and expertise and to deploy resources in addressing this important issue. The EC recognized the urgency and the EU tender European guidelines for the Medical Physics Expert (MPE) (TREN/H4/1672009) was issued to develop and update the role of MPEs in Europe. The final report has been approved by the EC and includes an agreed mission statement and key activities for MPEs. The new qualification framework defines the MPE as an MP who, through planned advanced training and CPD, achieves the highest level possible (i.e., European Qualifications Level 8) in her/his specialty. However, it is recognized that few Member States have the expertise and facilities to provide the necessary training. A preliminary survey among National Organisations of MP and medical device companies showed that a dedicated training scheme has become a necessity. Three end-users were identified: the hospital MPE, the scientist in industry and regulators assessing exposures in Diagnostic and Interventional Radiology. The EUTEMPE-RX consortium will develop, put into practice and evaluate a new pilot EFTS for the MPE in Diagnostic and Interventional Radiology, which includes both face-to-face and on-line teaching. The aim is to ensure that candidates become knowledgeable about all current issues in radiation safety culture in hospitals and to make the MPE a radiation protection advocate for patients. The course will address the themes identified in the MELODI strategic research agenda, DoreMi and EMAN projects. A business plan will be developed for the sustainability of the network, which would provide a template for the development of similar programmes in the other specialties of medical physics.
Esponda-Arguero M.,Mittelhessen University of Applied Sciences
Information Visualization | Year: 2010
This paper deals with techniques for the design and production of appealing algorithmic animations and their use in computer science education. A good visual animation is both a technical artifact and a work of art that can greatly enhance the understanding of an algorithm's workings. In the first part of the paper, I show that awareness of the composition principles used by other animators and visual artists can help programmers to create better algorithmic animations. The second part shows how to incorporate those ideas in novel animation systems, which represent data structures in a visually intuitive manner. The animations described in this paper have been implemented and used in the classroom for courses at university level. © 2010 Macmillan Publishers Ltd.
Hild S.,Helmholtz Center for Heavy Ion Research |
Hild S.,Mittelhessen University of Applied Sciences |
Durante M.,Helmholtz Center for Heavy Ion Research |
Durante M.,TU Darmstadt |
Bert C.,Helmholtz Center for Heavy Ion Research
International Journal of Radiation Oncology Biology Physics | Year: 2013
Purpose: To provide methods for quantification of uncertainties in 4-dimensional (4D) treatment during treatment planning. Methods and Materials: Uncertainty information was generated by multiple 4D treatment simulations with varying parameters. Sampled data were analyzed using uncertainty visualization methods that have been added to common treatment plan evaluation methods (eg, dose-volume histogram and dose distribution analysis). To illustrate the potential of the introduced methods, uncertainty analysis was completed for a single lung cancer case using 3 motion mitigation techniques: gating, slice-by-slice rescanning, and breath-controlled rescanning. Results: By repeating 4D dose calculations with varying parameters, we were able to show local uncertainties in dose distributions and to evaluate the stability of treatment setups. The new methods were found suitable for uncertainty evaluation in 4D treatment planning of moving tumors. Calculation time of the uncertainty base data was time consuming but contrivable overnight. Conclusions: Uncertainty analysis and visualization for 4D treatment planning provide an important tool in the decision process for an optimal treatment approach. © 2013 Elsevier Inc. All rights reserved.
Druzinec D.,Mittelhessen University of Applied Sciences
Methods in molecular biology (Clifton, N.J.) | Year: 2014
Modern bioprocesses demand for a careful definition of the critical process parameters (CPPs) already during the early stages of process development in order to ensure high-quality products and satisfactory yields. In this context, online monitoring tools can be applied to recognize unfavorable changes of CPPs during the production processes and to allow for early interventions in order to prevent losses of production batches due to quality issues. Process analytical technologies such as the dielectric spectroscopy or focused beam reflectance measurement (FBRM) are possible online monitoring tools, which can be applied to monitor cell growth as well as morphological changes. Since the dielectric spectroscopy only captures cells with intact cell membranes, even information about dead cells with ruptured or leaking cell membranes can be derived. The following chapter describes the application of dielectric spectroscopy on various virus-infected and non-infected cell lines with respect to adherent as well as suspension cultures in common stirred tank reactors. The adherent mammalian cell lines Vero (African green monkey kidney cells) and hMSC-TERT (telomerase-immortalized human mesenchymal stem cells) are thereby cultured on microcarrier, which provide the required growth surface and allow the cultivation of these cells even in dynamic culture systems. In turn, the insect-derived cell lines S2 and Sf21 are used as examples for cells typically cultured in suspension. Moreover, the FBRM technology as a further monitoring tool for cell culture applications has been included in this chapter using the example of Drosophila S2 insect cells.
Druzinec D.,Mittelhessen University of Applied Sciences
Advances in biochemical engineering/biotechnology | Year: 2013
Due to the increasing use of insect cell based expression systems in research and industrial recombinant protein production, the development of efficient and reproducible production processes remains a challenging task. In this context, the application of online monitoring techniques is intended to ensure high and reproducible product qualities already during the early phases of process development. In the following chapter, the most common transient and stable insect cell based expression systems are briefly introduced. Novel applications of insect cell based expression systems for the production of insect derived antimicrobial peptides/proteins (AMPs) are discussed using the example of G. mellonella derived gloverin. Suitable in situ sensor techniques for insect cell culture monitoring in disposable and common bioreactor systems are outlined with respect to optical and capacitive sensor concepts. Since scale up of production processes is one of the most critical steps in process development, a conclusive overview is given about scale up aspects for industrial insect cell culture processes.