Agency: European Commission | Branch: FP7 | Program: CSA-CA | Phase: Fission-2013-5.1.1 | Award Amount: 1.86M | Year: 2013
Medical exposures for radiological examinations represent the highest and fastest growing contribution to manmade radiation exposure in the EU underlying the need for medical physics experts (MPEs), regulators and scientists in industry to bring in new research results and expertise and to deploy resources in addressing this important issue. The EC recognized the urgency and the EU tender European guidelines for the Medical Physics Expert (MPE) (TREN/H4/1672009) was issued to develop and update the role of MPEs in Europe. The final report has been approved by the EC and includes an agreed mission statement and key activities for MPEs. The new qualification framework defines the MPE as an MP who, through planned advanced training and CPD, achieves the highest level possible (i.e., European Qualifications Level 8) in her/his specialty. However, it is recognized that few Member States have the expertise and facilities to provide the necessary training. A preliminary survey among National Organisations of MP and medical device companies showed that a dedicated training scheme has become a necessity. Three end-users were identified: the hospital MPE, the scientist in industry and regulators assessing exposures in Diagnostic and Interventional Radiology. The EUTEMPE-RX consortium will develop, put into practice and evaluate a new pilot EFTS for the MPE in Diagnostic and Interventional Radiology, which includes both face-to-face and on-line teaching. The aim is to ensure that candidates become knowledgeable about all current issues in radiation safety culture in hospitals and to make the MPE a radiation protection advocate for patients. The course will address the themes identified in the MELODI strategic research agenda, DoreMi and EMAN projects. A business plan will be developed for the sustainability of the network, which would provide a template for the development of similar programmes in the other specialties of medical physics.
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2011.1.5 | Award Amount: 3.97M | Year: 2011
So far, Hybrid Broadcast Internet applications have mostly linked Internet and broadcast by offering on-demand content in addition to current linear broadcast services and by replacing old-fashioned Teletext. However, many more services are on the horizon, and the market of hybrid and connected TV attracts attention from all stakeholders in the media value chain. The challenge is to take hybrid service to a new level where the wide range of expectations of user groups is met. HBB-NEXT will lay the foundations for advanced hybrid multi-user services by building upon existing standards and by enhancing them.\nThe project seeks to facilitate the convergence of the broadcast and Internet world by researching user- centric technologies for enriching the TV-viewing experience with social networking, multiple device access, group-tailored content recommendations, as well as the seamless mixing of broadcast content, of complementary Internet content and of user-generated content. The project will deliver a set of enablers to allow device-independent applications that can syndicate content from multiple sources, supporting real-time content composition and content distribution for users in geographically distinct areas. Sophisticated technology will be developed for the easy use of content, e.g. advanced synchronisation methods for service components delivered across the Internet and broadcast networks. Data security and protection of user privacy will be an integral part of HBB-NEXT - but in a way that is transparent to the end-user.\nIn liaison with the HbbTV Consortium, HBB-NEXT will define requirements and specifications for a secure multi-user and multi-device TV-viewing experience, thus fostering the implementation of new service concepts and business models.
Agency: European Commission | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2014 | Award Amount: 742.50K | Year: 2014
Our project aims to fill the gap between flexible electronic technology and design by developing highly predictive, generic, open-source, design-oriented organic and oxide based TFT compact model libraries, to be integrated in commercial Electron Design Automation (EDA) environments for full large area low cost circuit design for novel applications. These model libraries will be released together with parameter extraction standard templates to assist in the fast transfer between initial prototype device measurements to full product design. Such a facility will open the opportunity for wide flexible electronics design
Grein T.A.,Mittelhessen University of Applied Sciences
Methods in molecular biology (Clifton, N.J.) | Year: 2014
Industrial manufacturing of cell culture-derived viruses or virus-like particles for gene therapy or vaccine production are complex multistep processes. In addition to the bioreactor, such processes require a multitude of downstream unit operations for product separation, concentration, or purification. Similarly, before a biopharmaceutical product can enter the market, removal or inactivation of potential viral contamination has to be demonstrated. Given the complexity of biological solutions and the high standards on composition and purity of biopharmaceuticals, downstream processing is the bottleneck in many biotechnological production trains. Membrane-based filtration can be an economically attractive and efficient technology for virus separation. Viral clearance, for instance, of up to seven orders of magnitude has been reported for state of the art polymeric membranes under best conditions.This chapter summarizes the fundamentals of virus ultrafiltration, diafiltration, or purification with adsorptive membranes. In lieu of an impractical universally applicable protocol for virus filtration, application of these principles is demonstrated with two examples. The chapter provides detailed methods for production, concentration, purification, and removal of a rod-shaped baculovirus (Autographa californica M nucleopolyhedrovirus, about 40 × 300 nm in size, a potential vector for gene therapy, and an industrially important protein expression system) or a spherical parvovirus (minute virus of mice, 22-26 nm in size, a model virus for virus clearance validation studies).
Anton L.A.,Mittelhessen University of Applied Sciences |
Diaz J.,Mittelhessen University of Applied Sciences
Procedia Engineering | Year: 2014
Currently, the construction industry is turning towards sustainability. Nevertheless, in order to achieve a sustainable performance, a balance between environmental, social and economic criteria has to be created. There are already different tools available which have the potential to reach this goal. It is necessary to identify them as such and find out how they can be integrated to obtain synergies and contribute to sustainable construction. These tools have to be implemented in early design phases so as to add value to the project. In the present paper, two powerful methods, namely BIM and LCA, will be highlighted. Such methods can be of great assistance in the context of sustainability. On the one hand, BIM supports integrated design and improves information management and cooperation between the different stakeholders throughout the different project life-cycle phases. On the other hand, LCA is a suitable method for assessing environmental performance. Both LCA and BIM should be integrated in the decision-making process at an early stage with a view to achieving a holistic overview of the project, including environmental criteria, from the beginning. © 2014 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license.
Druzinec D.,Mittelhessen University of Applied Sciences
Methods in molecular biology (Clifton, N.J.) | Year: 2014
Modern bioprocesses demand for a careful definition of the critical process parameters (CPPs) already during the early stages of process development in order to ensure high-quality products and satisfactory yields. In this context, online monitoring tools can be applied to recognize unfavorable changes of CPPs during the production processes and to allow for early interventions in order to prevent losses of production batches due to quality issues. Process analytical technologies such as the dielectric spectroscopy or focused beam reflectance measurement (FBRM) are possible online monitoring tools, which can be applied to monitor cell growth as well as morphological changes. Since the dielectric spectroscopy only captures cells with intact cell membranes, even information about dead cells with ruptured or leaking cell membranes can be derived. The following chapter describes the application of dielectric spectroscopy on various virus-infected and non-infected cell lines with respect to adherent as well as suspension cultures in common stirred tank reactors. The adherent mammalian cell lines Vero (African green monkey kidney cells) and hMSC-TERT (telomerase-immortalized human mesenchymal stem cells) are thereby cultured on microcarrier, which provide the required growth surface and allow the cultivation of these cells even in dynamic culture systems. In turn, the insect-derived cell lines S2 and Sf21 are used as examples for cells typically cultured in suspension. Moreover, the FBRM technology as a further monitoring tool for cell culture applications has been included in this chapter using the example of Drosophila S2 insect cells.
Gusev A.S.,Moscow State University |
Egorov O.V.,Moscow State University |
Sakhibov F.,Mittelhessen University of Applied Sciences
Monthly Notices of the Royal Astronomical Society | Year: 2013
We study the photometric properties, chemical abundances and sizes of star formation regions in the two principal arms of the galaxy NGC 628 (M74). Galaxy Evolution Explorer (GALEX) ultraviolet, optical UBVRI and Hα surface photometry data are used, including those obtained with the 1.5-m telescope of the Maidanak Observatory. The 30 brightest star formation regions in ultraviolet light located in the spiral arms of NGC 628 are identified and studied. We find that the star formation regions in one (longer) arm are systematically brighter and larger than the regions in the other (shorter) arm. However, both luminosity and size distribution functions have approximately the same slopes for the samples of star formation regions in both arms. The star formation regions in the longer arm have a higher star formation rate density than the regions in the shorter arm. The regions in the shorter arm show higher N/O ratio at a higher oxygen abundance, but they have lower ultraviolet and Hα luminosities. These findings can be explained if we assume that star formation regions in the shorter arm had a higher star formation rate in the past, but it is now lower than that in the opposite arm. Results of stellar evolutionary synthesis show that the brightest regions in the longer arm are slightly younger than those in the shorter arm (3.5 ± 2.2 Myr versus 6.0 ± 1.1Myr). Our results demonstrate that there is a difference in inner structure and parameters of the interstellar medium between the spiral arms of NGC 628, one of which is long and hosts a regular chain of bright star formation complexes, while the other, shorter, one does not.© 2013 The Authors.
Druzinec D.,Mittelhessen University of Applied Sciences
Advances in biochemical engineering/biotechnology | Year: 2013
Due to the increasing use of insect cell based expression systems in research and industrial recombinant protein production, the development of efficient and reproducible production processes remains a challenging task. In this context, the application of online monitoring techniques is intended to ensure high and reproducible product qualities already during the early phases of process development. In the following chapter, the most common transient and stable insect cell based expression systems are briefly introduced. Novel applications of insect cell based expression systems for the production of insect derived antimicrobial peptides/proteins (AMPs) are discussed using the example of G. mellonella derived gloverin. Suitable in situ sensor techniques for insect cell culture monitoring in disposable and common bioreactor systems are outlined with respect to optical and capacitive sensor concepts. Since scale up of production processes is one of the most critical steps in process development, a conclusive overview is given about scale up aspects for industrial insect cell culture processes.
Mittelhessen University of Applied Sciences | Date: 2015-12-23
The present disclosure relates to novel natural sweetener compositions and methods for producing such sweetener compositions having improved taste quality and their use in various food products and beverages as a sweetness and flavor modifier.
Mittelhessen University of Applied Sciences | Date: 2010-07-19
Reinforced concrete component with at least one upper and at least one lower longitudinal reinforcement layer, and one transverse force reinforcement. Transverse force reinforcement being passed to the upper and lower longitudinal reinforcement in its extension. The transverse force reinforcement is formed by at least 20 L-shaped sheet metal components made from structural steel with stirrups attached thereto. Each sheet metal component thereby comprises a chamfer.