Mitsui Chemicals Asia Pacific Ltd.

Singapore, Singapore

Mitsui Chemicals Asia Pacific Ltd.

Singapore, Singapore
SEARCH FILTERS
Time filter
Source Type

Ramalingam B.,Institute of Chemical and Engineering Sciences, Singapore | Seayad A.M.,Institute of Chemical and Engineering Sciences, Singapore | Chuanzhao L.,Institute of Chemical and Engineering Sciences, Singapore | Garland M.,Institute of Chemical and Engineering Sciences, Singapore | And 4 more authors.
Advanced Synthesis and Catalysis | Year: 2010

Close to perfect enantioselectivity (up to 98% ee) is obtained for the formation of amino nitrites using hydrogen cyanide (HCN) as the cyanide source at room temperature for the first time. In an operationally simple process, the catalyst generated from a partially hydrolyzed titanium alkoxide (PHTA) and (S)-N-salicyl-ß-amino alcohol ligand, catalyzes the cyanation of imines in a short reaction time. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinlieim.


Seayad A.M.,Institute of Chemical and Engineering Sciences, Singapore | Ramalingam B.,Institute of Chemical and Engineering Sciences, Singapore | Yoshinaga K.,Mitsui Chemicals Asia Pacific Ltd. | Nagata T.,Mitsui Chemicals Asia Pacific Ltd. | Chai C.L.L.,Institute of Chemical and Engineering Sciences, Singapore
Organic Letters | Year: 2010

(Figure presented) A highly active and enantioselective titanium-catalyzed cyanatlon of imines at room temperature Is described. The catalyst used Is a partially hydrolyzed titanium alkoxide (PHTA) precatalyst together with a readily available N-salicyl-β-aminoalcohol ligand. Up to 98% ee was obtained with quantitative yields In 15 min of reaction time using 5 mol % of the catalyst. Various N-protecting groups such as benzyl, benzhydryl, Boc, and PMP are tolerated. © 2010 American Chemical Society.

Loading Mitsui Chemicals Asia Pacific Ltd. collaborators
Loading Mitsui Chemicals Asia Pacific Ltd. collaborators