The Mitsubishi Group is a group of autonomous Japanese multinational companies covering a range of businesses which share the Mitsubishi brand, trademark, and legacy.The Mitsubishi group of companies form a loose entity, the Mitsubishi Keiretsu, which is often referenced in Japanese and US media and official reports; in general these companies all descend from the zaibatsu of the same name. The top 25 companies are also members of the Mitsubishi Kin'yōkai, or "Friday Club", and meet monthly. The Mitsubishi.com Committee facilitate communication and access to the Mitsubishi brand through a portal web site. Wikipedia.
Nomura S.,Mitsubishi Group
Current Topics in Medicinal Chemistry | Year: 2010
Plasma glucose is continuously filtered through the glomerulus and then is reabsorbed via the transcellular transport system of proximal tubules in the kidney. The glucose reabsorption system in the kidney is mediated by sodiumdependent glucose cotransporters (SGLTs). Most of filtered glucose is reabsorbed by the low affinity, high capacity SGLT2 located in the proximal renal tubule. SGLT2 inhibitors, such as T-1095, enhance urinary glucose excretion and consequently lower blood glucose levels independent of insulin action. The principle behind SGLT inhibition involves the amelioration of diabetic conditions without increasing body weight and the risk of hypoglycemia. A number of SGLT2 inhibitors are being developed for the treatment of diabetes. This review offers the summary of structure-activity relationships (SARs) and pharmacological profiles of T-1095 and diverse SGLT2 inhibitors. © 2010 Bentham Science Publishers Ltd.
Arii M.,Mitsubishi Group
IEEE Transactions on Geoscience and Remote Sensing | Year: 2014
Current motion compensation algorithms for a moving object on synthetic aperture radar (SAR) imagery by refocusing are accurate, but they suffer from a severe computational efficiency problem. If the step size of an assumed target velocity is too large, one could miss the true target velocity, whereas too small a step size would lead to a considerable computation load. To address this issue, the way motion error affects a compressed signal should be understood. In this paper, we introduce the concept of velocity correlation function (VCF) to describe the sensitivity of an SAR compressed signal to motion error. We propose its analytical model by straightforwardly tackling conventional matched filtering, and then we thoroughly compare the model with the experimentally obtained VCF for each static and moving object on real L-band airborne/spaceborne SAR imagery. The analytically derived VCF is well validated, as it shows excellent agreement with those experiments. Finally, the VCF is generalized to a velocity correlation map to visualize a sensitivity of SAR system parameters to target motion in both the range and the azimuth directions simultaneously. © 2013 IEEE.
Okano K.,Mitsubishi Group
Tetrahedron | Year: 2011
In this review, the author summarized the history and recent topics of the chemistry of chiral hydrobenzoin. The long history of this molecule reflects the advance of chiral chemistry. The various applications that have been developed in this history reveal the wide ability and utility of chiral hydrobenzoin as chiral ligands, chiral auxiliaries, and functional compounds. Recent advances in the practical preparation of chiral hydrobenzoin, including asymmetric dihydroxylation and asymmetric transfer hydrogenation, will contribute both to the preparation of various derivatives of hydrobenzoin for optimization of the structure and to large-scale synthesis in industrial use. As the most useful chiral diol, hydrobenzoin will continue to show various features in the future. © 2011 Elsevier Ltd. All rights reserved.
Oguri K.,Mitsubishi Group
Journal of Materials Processing Technology | Year: 2011
Fine Particle Shot Peening (FPSP) enhances fatigue properties of aluminum parts for aerospace compared with conventional shot peening (SP). The features of FPSP process are small ceramic media and high velocity of the media flow. Fatigue life of aluminum alloy obtained by FPSP is around one order of magnitude longer than that by SP. And the superior fatigue property unchanged even after anodize for corrosion protection. FPSP creates fine dimples with small surface roughness and high compressive residual stress at very near surface, while SP forms large dimples and high compressive stress inside of the material. The fatigue crack occurred at the subsurface in case of FPSP, while at the surface in case of SP and machined. The fatigue crack initiation at the subsurface is the reason of superior fatigue life by FPSP. © 2011 Elsevier B.V. All rights reserved.
Kadowaki T.,University of Tokyo |
Kondo K.,Mitsubishi Group
Diabetes, Obesity and Metabolism | Year: 2013
Aim: To assess the efficacy, safety and dose-response relationship of once-daily teneligliptin, a novel dipeptidyl peptidase-4 inhibitor, in Japanese patients with type 2 diabetes mellitus (T2DM) inadequately controlled with diet and exercise. Methods: In this randomized, double-blind, placebo-controlled, parallel-group study, patients (n=324) were randomized to receive teneligliptin 10, 20 or 40mg, or placebo, once daily before breakfast for 12weeks. The primary endpoint was the change in haemoglobin (Hb)A1c from baseline to week 12. Results: All teneligliptin-treated groups showed significantly greater reductions in HbA1c and fasting plasma glucose (FPG) than did the placebo group. The differences between the teneligliptin 10, 20 or 40mg groups and the placebo group for the change in HbA1c were -0.9 [least-squares (LS) mean; 95% confidence interval: -1.0, -0.7], -0.9 (-1.1, -0.7) and -1.0 (-1.2, -0.9)%, respectively (all, p<0.001). The respective LS means for FPG were -17.8 (-23.4, -12.1), -16.9 (-22.6, -11.2) and -20.0 (-25.7, -14.3) mg/dl (all, p<0.001). There were no significant differences in HbA1c among the three doses of teneligliptin. The incidence of adverse events and adverse drug reactions was similar in each group. The incidence of hypoglycaemia was not significantly different among the four groups. Conclusions: Treatment with teneligliptin for 12weeks provided significant and clinically meaningful reductions in HbA1c and FPG across the dose range studied and was generally well tolerated in Japanese patients with T2DM. © 2013 Blackwell Publishing Ltd.