Mithibai College

Mumbai, India

Mithibai College

Mumbai, India
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Nadkarni N.G.,Patkar College | Mangaonkar K.V.,Mithibai College
E-Journal of Chemistry | Year: 2011

Binary and ternary complexes of the type M-Y and M-X-Y [M = Mn(II), Ni(II), Cu(II) and Zn(II); X = 5-bromosalicylidene-4-methoxyaniline and Y = salicylidene-2,3-dimethylaniline] have been examined pH-metrically at 27±0.5 °C and at constant ionic strength, μ = 0.1 M (KCl) in 75 : 25(v/v) 1,4-dioxne-water medium. The stability constants for binary (M-Y) and ternary (M-X-Y) systems were calculated. © Copyright E-Journal of Chemistry 2004-2011.


Gala V.,Narsee Monjee Institute of Management and Higher Studies | Desai K.,Mithibai College
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2014

Phytochemical research has gained a lot of momentum in the medical field for the discovery of new, safe, and effective remedies. In the context of antimicrobial research, various plant sources have been discovered with the potential to disrupt bacterial quorum sensing (QS), which plays a key role in the regulation of virulence in many Gram positive and Gram negative bacteria. Pseudomonas aeruginosa, a Gram negative bacterium, is known to produce multiple QS systems that control the expression of virulence determinants and biofilm development in this pathogen. Hence, the inhibition of QS has been pursued as a promising therapy for treatment of drug resistant Pseudomonas infections. A comprehensive review of the research data available for plant products as QS inhibitors of the organism has been presented here, while further suggesting the future prospects for these inhibitors. © 2014, IJPPS. All rights reserved.


Deepak S.,Mithibai College | Kamat S.D.,Mithibai College | Kamat D.V.,Mithibai College
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2010

ESBL mediated resistance in Gram negative organisms poses a serious problem. Also AmpC may coexist with other types of ESBL and mask each other, thus making detection even more difficult. The aim of this study was to find Gram negative organisms from clinical isolates, analyze their resistance patterns, identify the various types of ESBLs produced and study synergistic action of the aqueous extract of Terminalia chebula with cefotaxime. Fifteen isolates each of Pseudomonas aeruginosa and Acinetobacter baumannii were obtained from hospitals in Mumbai. The resistance pattern towards various cephalosporins was studied. The types of enzymes responsible for antibiotic resistance were also established. Various crude phytochemical extracts were evaluated for their effect on the ESBL produced. Aqueous extract from Terminalia chebula was found to be effective on MBL which were produced by eleven isolates of Pseudomonas and eight isolates of Acinetobacter.


Chunduri J.R.,Mithibai College | Shah H.R.,Mithibai College
International Journal of Current Pharmaceutical Review and Research | Year: 2016

Objective: phytochemical screening and antioxidant activity analyses of selected indoor plants and to evaluate commercial applications. Methods: Qualitative and quantitative phytochemical analyses of alcoholic and aquatic crude extracts of leaves of selected non-flowering indoor plants were assessed using standard protocols and later compared with FTIR analyses. Antioxidant and antibacterial activities of the extracts were studied Results: Phytochemical analysis of polar solvent extractions of the four selected plants Pedilanthus tithymaloides, Cordyline terminalis, Tradescantia zebrine and Rhoeo discolou. Indicated the presence of tannins in all four varieties terpenoids in 3, flavonols, phytosterols and phenols in two plants, followed by alkaloids. The phytochemical analyses were supported by FTIR reports. Quantitative studies indicated variations in flavonol, tannin and phenols concentrations among the four species. High concentrations of Total flavonols (P. tithymaloides) and Tannins (C. terminalis) were observed. C. terminalis extract showed comparatively highest reducing power followed by R. discolour and P. tithymaloides extracts. Antibiotic Sensitivity Testing indicated P. tithymaloides showed a maximum zone of inhibition compared to R. discolor. C. terminalis plant leaf extract showed a faint zone of inhibition against E. fecalis while others couldnot. Intense colors of C. terminalis and T. zebrine plants could be used as a natural dye as well as pH indicator. Conclusion: The rich concentrations of the tannins from non-flowering indoor plants could be the future option of dyes and dyeing industry as natural colorants as well as pH indicators. These plants were rich sources of phytochemicals (phenols, flavonols, tannins, and phytosterols), with antioxidant and antibacterial activity. © 2016 The Authors.


Mapari A.K.,Ramnarain Ruia College | Mangaonkar K.V.,Mithibai College
International Journal of ChemTech Research | Year: 2011

Binary and ternary complexes of the type M-Y and M-X-Y [M = Co(II), Ni(II), Cu(II) and Zn(II); X = N-(2- hydroxybenzylidene)-2,3-dimethylaniline and Y = N-(2-hydroxy-1-naphthylidene)-4-chloroaniline] have been examined pH-metrically at 27 ± 0.5°C and at constant ionic strength, μ = 0.1 M (KCl) in 75: 25 (v/v) 1,4-dioxne-water medium. The stability constants for Binary (M-Y) and ternary (M-X-Y) systems were calculated.


Binary and ternary complexes of the type M-Y and M-X-Y [M = Co(II), Ni(II), Cu(II) and Zn(II); X = N-(2-hydroxy-1-naphthylidene)-2,6-diisopropylaniline and Y = N-(2-hydroxybenzylidene)-2,3-dimethylaniline] have been examined pH-metrically at 27±0.5 °C and μ = 0.1 M in 75: 25% (v/v) 1,4-dioxne-water medium. The logarithms of the values of stability constants for binary (M-Y) and for ternary (M-X-Y) systems were calculated.


Mapari A.K.,Ramnarain Ruia College | Mangaonkar K.V.,Mithibai College
E-Journal of Chemistry | Year: 2011

The mixed ligand complexes of Co(II), Ni(II), Cu(II) and Zn(II) with Schiff bases N-(2-hydroxy-1-naphthylidene)-4-methylaniline (L1H) and N-(2-hydroxybenzylidene)-2,3-dimethylaniline (L2H) have been synthesized and characterized. The resulting complexes were characterized by elemental analysis, thermogravimetric analysis, magnetic moment measurements, conductivity measurements, 1H NMR, IR, UV-visible and ESR spectral studies. The Schiff bases acts as bidentate monobasic ligands, coordinating through deprotonated phenolic oxygen and azomethine nitrogen atoms. The complexes are non-electrolytic in DMSO. The presence of the two coordinated water molecules in these complexes was indicated by IR spectra and thermogravimetric analysis of the complexes. From the analytical and spectral data the stoichiometry of these complexes have been found to be [M(L1)(L2)(H2O) 2] {where M = Co(II) , Ni(II), Cu(II) and Zn(II)}. It is found that Co(II), Ni(II), Cu(II) and Zn(II) complexes exhibited octahedral geometry. The antimicrobial activities of ligands and their mixed ligand complexes were screened by disc diffusion method. It is found that the metal complexes have higher antimicrobial activity than the free ligand.


Binary and ternary complexes of the type M-Y and M-X-Y [M = Mn(II), Ni(II), Cu(II) and Zn(II); X = salicylidene-4-methoxyaniline and Y=5-bromosalicylidene- 4-nitroaniline] have been examined pH-metrically at 27±0.5 °C and at constant ionic strength, μ = 0.1 M (KCl) in 75 : 25(v/v) 1,4-dioxne-water medium. The stability constants for binary (M-Y) and ternary (M-X-Y) systems were calculated. The relative stability (Δ log KT) values of the ternary complexes with corresponding binary complexes for all the metal(II) ions in the present study found to be negative indicating that ternary 1:1:1 (M-X-Y) complexes are less stable than binary 1:1 (M-Y) complexes. In the ternary system studied, the order of stability constants of mixed ligand complexes with respect to the metal ions was found to be Cu(II)>NI(II) >Mn(II)>Zn(II); which is same as in the corresponding binary (M-Y) systems. © Copyright E-Journal of Chemistry 2004-2011.


Gadkari D.,Mithibai College
Materials Chemistry and Physics | Year: 2013

Vertical directional solidification (VDS) technique is used on the combined growth principals of the conventional methods since 1994, which leads to the detached growth. For evaluation of the detached growth, five bulk ingots of indium doped gallium-antimonide GaSb:In (In = 0.5, 0.25, 0.15) have been grown-without the seed, without contact to the ampoule wall, without coating and without external pressure. The gap is attributed to compensate the differential thermal dilatation that is grown with the reduced diameter than the diameter of the ampoule. VDS experiments have been proved that the sum of the contact angle and growth angle is large enough to allow detachment without any additional pressure difference under the melt to offset hydrostatic pressure. A meniscus forms at the bottom of the melt, the capillarity effect establishes due to which spontaneous gap could be created by the melt free surface, thus no thermal shear stress and thermo-mechanical stresses at the interface. Detached grown bulk GaSb:In crystals showed superior crystal quality with the highest physical properties and mobility than the crystals grown ever. The axial and radial composition profile of the grown GaSb:In ingots showed variation ≤10%. From the conical region, dislocation density decreases in the growth direction and reaches less than 103 cm-2. © 2013 Elsevier B.V. All rights reserved.


Gadkari D.B.,Mithibai College
AIP Conference Proceedings | Year: 2013

Since 1994, vertical directional solidification (VDS) technique is based on the combined growth principal of the conventional methods, which leads to the detached growth and crystal perfection. InSb:Te bulk crystals grown under detachment showed the highest mobility and physical properties. It reveals the thermocapillary and composition control in Te doped InSb ingots by the influence of detached growth, where dislocation density has been reduced significantly. © 2013 American Institute of Physics.

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