Córdoba, Argentina
Córdoba, Argentina

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Cosacov R.,Hospital Misericordia | Villarreal G.,Hospital Misericordia
Neurologia Argentina | Year: 2016

Susac's syndrome is a rare disease, characterized by encephalopathy, sensorineural hearing loss and retinal artery occlusion. In this paper, we present the case of a woman who presented the complete triad, with typical features on Nuclear Magnetic Resonance images of the brain, and we review other cases reported in our country. © 2016 Sociedad Neurológica Argentina.

Cosacov R.,Hospital Misericordia | Spadaro E.,Centro Privado Of Tomografia | Villareal G.,Hospital Misericordia
Neurologia Argentina | Year: 2011

Takayasu arteritis (TA) is a rare disease manifesting as chronic idiopathic vasculitis of aorta, its branches and pulmonary artery. It mainly affects young women. Early manifestations are fever, malaise and weight loss, and later, pulseless limbs, aneurysms, hypertension, heart failure and neurological damage. Stroke as the first manifestation of TA is unusual and is the subject of this report. © 2011 Sociedad Neurológica Argentina. Published by Elsevier España, S.L. All rights.

PubMed | University of Rome La Sapienza, Hospital Misericordia and Palagi Hospital
Type: | Journal: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians | Year: 2016

To evaluate the effectiveness of three different first trimester screening models for trisomies 21, 18 and 13, in terms of detection rate, invasive test rate and final costs.We analyzed the distribution of risk for trisomies 21, 18 and 13 in a population of 20,831 singleton pregnancies based on maternal age, fetal heart rate, nuchal translucency, free beta human chorionic gonadotropin and pregnancy-associated plasma protein A (Combined test). On the basis of our data, we estimated the performance and cost of screening for trisomies using three different models at specific cutoffs: Combined test; Cell free DNA test and Contingent screening test.Using Combined test, DR for major trisomies was estimated to be 94.92%, invasive test rate was 6.3%. cfDNA would result in a DR of 97.92%, with an invasive test rate of 3.64%. Contingent screening approach would result in an overall DR of 97.82, with a rate for invasive procedure of 1.36% and a final cost lower than other screening policies (2,338,433euro vs 5,796,060 of cfDNA and 2,385,473 of Combined test).Contingent screening test could be a cost-efficient and feasible first trimester screening test for aneuploidies in public health system.

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