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Yang L.,Ministry of Health and China National Center for Food Safety Risk Assessment | Yang L.,Hong Kong Baptist University | Wang Z.,Peking Union Medical College | Shi Y.,Ministry of Health and China National Center for Food Safety Risk Assessment | And 5 more authors.
Chemosphere | Year: 2016

Perfluoroalkyl acids (PFAAs) precursors, the indirect source of PFAA exposure, have been observed in environmental and human samples. However, the maternal-fetal transfer of these chemicals has not been well examined. In this study, 50 paired maternal and cord serum samples collected in Jiangsu province of China were analyzed for fifteen PFAA precursors. Among the detected PFAAs, 6:2 fluorotelomer sulfonate (6:2 FTS), N-methyl- and N-ethyl-perfluorooctanesulfonamidoacetates had comparable detection rate in both maternal and cord sera, while the mean concentrations and detection rates of 8:2 FTS and perfluorooctane sulfonamide (PFOSA) were higher in maternal sera compared to cord sera (Mann-Whitney U test, P < 0.05). Analysis of variance and least significant difference tests showed that the youngest maternal age group (21-24 years old) had the highest concentration of 6:2 FTS in cord sera. Maternal serum PFOSA was found significantly correlated with the cord serum perfluorooctanesulfonate (PFOS) (Spearman test, r = 0.361, P = 0.010), indicating that maternal serum PFOSA might be an indirect source of PFOS in fetuses. The obtained results suggested the potential prenatal exposure and human placental transfer of perfluoroalkyl acid precursors. © 2015 Elsevier Ltd.


PubMed | Hong Kong Baptist University, Ministry of Health and China National Center for Food Safety Risk Assessment and Peking Union Medical College
Type: | Journal: Chemosphere | Year: 2015

Perfluoroalkyl acids (PFAAs) precursors, the indirect source of PFAA exposure, have been observed in environmental and human samples. However, the maternal-fetal transfer of these chemicals has not been well examined. In this study, 50 paired maternal and cord serum samples collected in Jiangsu province of China were analyzed for fifteen PFAA precursors. Among the detected PFAAs, 6:2 fluorotelomer sulfonate (6:2 FTS), N-methyl- and N-ethyl-perfluorooctanesulfonamidoacetates had comparable detection rate in both maternal and cord sera, while the mean concentrations and detection rates of 8:2 FTS and perfluorooctane sulfonamide (PFOSA) were higher in maternal sera compared to cord sera (Mann-Whitney U test, P < 0.05). Analysis of variance and least significant difference tests showed that the youngest maternal age group (21-24 years old) had the highest concentration of 6:2 FTS in cord sera. Maternal serum PFOSA was found significantly correlated with the cord serum perfluorooctanesulfonate (PFOS) (Spearman test, r = 0.361, P = 0.010), indicating that maternal serum PFOSA might be an indirect source of PFOS in fetuses. The obtained results suggested the potential prenatal exposure and human placental transfer of perfluoroalkyl acid precursors.


Liu X.,Ministry of Health and China National Center for Food Safety Risk Assessment | Liu X.,U.S. Center for Disease Control and Prevention | Wen S.,Ministry of Health and China National Center for Food Safety Risk Assessment | Wen S.,U.S. Center for Disease Control and Prevention | And 4 more authors.
Environmental Monitoring and Assessment | Year: 2016

The levels of a 2,2′,4,4′,5,5′-hexabromobiphenyl (BB-153) were measured in human milk samples collected in 2007 and 2011 from residents in China by high-resolution gas chromatography–high-resolution mass chromatography (HRGC–HRMS) with isotope dilution. The median concentrations of BB-153 from the samples collected in 2007 and 2011 were 8.3 and 7.2 pg/g lipid weight, respectively. The levels of BB-153 in the human milk collected from rural areas were not significantly different to those collected from the urban areas in China. Meanwhile, significant positive correlations were found between the levels of BB-153 in human milk and the consumption of animal-origin foods. In the present study, the mean levels of BB-153 in human milk from Chinese mothers were found to be lower than those from European and American mothers. © 2016, Springer International Publishing Switzerland.


Gao J.,Ministry of Health and China National Center for Food Safety Risk Assessment | Zhao Y.,Ministry of Health and China National Center for Food Safety Risk Assessment | Zhu F.,U.S. Center for Disease Control and Prevention | Ma Y.,U.S. Center for Disease Control and Prevention | And 3 more authors.
Food and Chemical Toxicology | Year: 2016

The levels of acrylamide in 240 food composite samples from the 5th Chinese Total Diet Study (TDS) were measured using an LC-MS/MS method and the exposure estimates for the general population were evaluated. The samples were collected from 20 provinces in China, covering about two thirds of the Chinese population. Acrylamide was detected in 40.0% of composite samples with the concentrations ranged from 0.8 to 211.8 μg/kg. The average dietary intakes from the 5th Chinese TDS were 0.319 μg kg-1 bw day-1 and an increase with about 70% was observed from the 3rd Chinese TDS in 2000 to the 5th Chinese TDS between 2009 and 2012. The main food group contributors to acrylamide exposure were vegetables (35.2%), cereals (34.3%) and potatoes (15.7%). Based on the benchmark dose lower confidence limit at 10% risk (BMDL10) of 0.31 mg kg-1 bw day-1 for the induction of mammary tumors in rats and 0.18 mg kg-1 bw day-1 for Harderian gland tumors in mice, the margins of exposure (MOEs) were 973 and 565 for Chinese general population, respectively. These MOEs indicate a human health concern. © 2015 Elsevier Ltd.


PubMed | Hong Kong Baptist University, National Institute of Nutrition and Health and Ministry of Health and China National Center for Food Safety Risk Assessment
Type: | Journal: Scientific reports | Year: 2016

Perfluoroalkyl substances (PFASs) have been detected in wildlife and human samples worldwide. Toxicology research showed that PFASs could interfere with thyroid hormone homeostasis. In this study, eight PFASs, fifteen PFAS precursors and five thyroid hormones were analyzed in 157 paired maternal and cord serum samples collected in Beijing around delivery. Seven PFASs and two precursors were detected in both maternal and cord sera with significant maternal-fetal correlations (r=0.336 to 0.806, all P<0.001). The median ratios of major PFASs concentrations in fetal versus maternal serum were from 0.25:1 (perfluorodecanoic acid, PFDA) to 0.65:1 (perfluorooctanoic acid, PFOA). Spearman partial correlation test showed that maternal thyroid stimulating hormone (TSH) was negatively correlated with most maternal PFASs (r=-0.261 to -0.170, all P<0.05). Maternal triiodothyronin (T3) and free T3 (FT3) showed negative correlations with most fetal PFASs (r=-0.229 to -0.165 for T3; r=-0.293 to -0.169 for FT3, all P<0.05). Our results suggest prenatal exposure of fetus to PFASs and potential associations between PFASs and thyroid hormone homeostasis in humans.


PubMed | National Institute of Nutrition and Health, Ministry of Health and China National Center for Food Safety Risk Assessment and China National Institute for Nutrition and Food Safety
Type: | Journal: Chemosphere | Year: 2016

Perfluoroalkyl substances (PFASs), a group of environmental pollutants, persistently exist in the environment. To investigate the associations between PFASs levels in cord serum and birth weight, birth length and ponderal index, we measured PFASs in cord serum samples from 170 infants from Feb. 2012 to Jun. 2012 in Beijing, China. The mean concentrations in cord serum samples for perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorohexane sulfonic acid (PFHxS), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA) and perfluoroundecanoic acid (PFUnA) were 1.285ng/mL, 1.228ng/mL, 0.230ng/mL, 0.224ng/mL, 0.100ng/mL and 0.085ng/mL, respectively. First-born children had slightly higher exposure levels of PFHxS (p<0.001) and PFOA (p=0.03) than second-born or third-born children. The spearman correlation coefficients with gestation time were individually 0.160 (p=0.038) for PFHxS and 0.202 (p=0.008) for PFOA. Both univariate and multivariate linear regression analysis showed that the exposure levels of PFASs had no statistically significant associations with birth weight, birth length or ponderal index in the present population. For male infants, we observed that PFHxS positively correlated with birth length, but the levels of PFUnA were negatively associated with birth length.


PubMed | Ministry of Health and China National Center for Food Safety Risk Assessment
Type: Journal Article | Journal: Environmental monitoring and assessment | Year: 2016

The levels of a 2,2,4,4,5,5-hexabromobiphenyl (BB-153) were measured in human milk samples collected in 2007 and 2011 from residents in China by high-resolution gas chromatography-high-resolution mass chromatography (HRGC-HRMS) with isotope dilution. The median concentrations of BB-153 from the samples collected in 2007 and 2011 were 8.3 and 7.2pg/g lipid weight, respectively. The levels of BB-153 in the human milk collected from rural areas were not significantly different to those collected from the urban areas in China. Meanwhile, significant positive correlations were found between the levels of BB-153 in human milk and the consumption of animal-origin foods. In the present study, the mean levels of BB-153 in human milk from Chinese mothers were found to be lower than those from European and American mothers.


PubMed | U.S. Center for Disease Control and Prevention and Ministry of Health and China National Center for Food Safety Risk Assessment
Type: | Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association | Year: 2016

The levels of acrylamide in 240 food composite samples from the 5th Chinese Total Diet Study (TDS) were measured using an LC-MS/MS method and the exposure estimates for the general population were evaluated. The samples were collected from 20 provinces in China, covering about two thirds of the Chinese population. Acrylamide was detected in 40.0% of composite samples with the concentrations ranged from 0.8 to 211.8g/kg. The average dietary intakes from the 5th Chinese TDS were 0.319gkg(-1)bwday(-1) and an increase with about 70% was observed from the 3rd Chinese TDS in 2000 to the 5th Chinese TDS between 2009 and 2012. The main food group contributors to acrylamide exposure were vegetables (35.2%), cereals (34.3%) and potatoes (15.7%). Based on the benchmark dose lower confidence limit at 10% risk (BMDL10) of 0.31mgkg(-1)bwday(-1) for the induction of mammary tumors in rats and 0.18mgkg(-1)bwday(-1) for Harderian gland tumors in mice, the margins of exposure (MOEs) were 973 and 565 for Chinese general population, respectively. These MOEs indicate a human health concern.


PubMed | Ministry of Health and China National Center for Food Safety Risk Assessment
Type: Journal Article | Journal: Journal of agricultural and food chemistry | Year: 2013

A national survey of polybrominated diphenyl ethers (PBDEs) and indicator polychlorinated biphenyls (PCBs) congeners in various foodstuffs from the Chinese total diet study (TDS) performed in 2007 was conducted for the first time. Meats and aquatic foods had the highest average sum PBDEs (192.5 and 190.6 pg g fresh weight, respectively). For indicator PCBs, the highest average concentration was found in aquatic foods (628.7 pg g fresh weight). On the basis of measured PBDE and indicator PCB levels, the dietary intake estimate was subsequently calculated for the nonoccupationally exposed population in China. For adults, average estimated dietary intakes of PBDEs and indicator PCBs were 0.76 and 2.34 ng kg bw day, respectively. Health risk assessment of PBDEs using a MOE approach recommended by EFSA suggested unlikely health concern with respect to current dietary intake of PBDEs in China.

Loading Ministry of Health and China National Center for Food Safety Risk Assessment collaborators
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