Yang L.,Ministry of Health and China National Center for Food Safety Risk Assessment |
Yang L.,Hong Kong Baptist University |
Wang Z.,Peking Union Medical College |
Shi Y.,Ministry of Health and China National Center for Food Safety Risk Assessment |
And 5 more authors.
Perfluoroalkyl acids (PFAAs) precursors, the indirect source of PFAA exposure, have been observed in environmental and human samples. However, the maternal-fetal transfer of these chemicals has not been well examined. In this study, 50 paired maternal and cord serum samples collected in Jiangsu province of China were analyzed for fifteen PFAA precursors. Among the detected PFAAs, 6:2 fluorotelomer sulfonate (6:2 FTS), N-methyl- and N-ethyl-perfluorooctanesulfonamidoacetates had comparable detection rate in both maternal and cord sera, while the mean concentrations and detection rates of 8:2 FTS and perfluorooctane sulfonamide (PFOSA) were higher in maternal sera compared to cord sera (Mann-Whitney U test, P < 0.05). Analysis of variance and least significant difference tests showed that the youngest maternal age group (21-24 years old) had the highest concentration of 6:2 FTS in cord sera. Maternal serum PFOSA was found significantly correlated with the cord serum perfluorooctanesulfonate (PFOS) (Spearman test, r = 0.361, P = 0.010), indicating that maternal serum PFOSA might be an indirect source of PFOS in fetuses. The obtained results suggested the potential prenatal exposure and human placental transfer of perfluoroalkyl acid precursors. © 2015 Elsevier Ltd. Source
Gao J.,Ministry of Health and China National Center for Food Safety Risk Assessment |
Zhao Y.,Ministry of Health and China National Center for Food Safety Risk Assessment |
Zhu F.,U.S. Center for Disease Control and Prevention |
Ma Y.,U.S. Center for Disease Control and Prevention |
And 3 more authors.
Food and Chemical Toxicology
The levels of acrylamide in 240 food composite samples from the 5th Chinese Total Diet Study (TDS) were measured using an LC-MS/MS method and the exposure estimates for the general population were evaluated. The samples were collected from 20 provinces in China, covering about two thirds of the Chinese population. Acrylamide was detected in 40.0% of composite samples with the concentrations ranged from 0.8 to 211.8 μg/kg. The average dietary intakes from the 5th Chinese TDS were 0.319 μg kg-1 bw day-1 and an increase with about 70% was observed from the 3rd Chinese TDS in 2000 to the 5th Chinese TDS between 2009 and 2012. The main food group contributors to acrylamide exposure were vegetables (35.2%), cereals (34.3%) and potatoes (15.7%). Based on the benchmark dose lower confidence limit at 10% risk (BMDL10) of 0.31 mg kg-1 bw day-1 for the induction of mammary tumors in rats and 0.18 mg kg-1 bw day-1 for Harderian gland tumors in mice, the margins of exposure (MOEs) were 973 and 565 for Chinese general population, respectively. These MOEs indicate a human health concern. © 2015 Elsevier Ltd. Source