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Catana M.,Bagdasar Arseni Emergency Hospital | Francisc A.,National Institute of Legal Medicine Mina Minovici
Romanian Journal of Legal Medicine | Year: 2012

The authors present two cases of traumatic spondylolisthesis operated during the period Jan. 2009 - May 2012, at the Department of Neurosurgery IV of the "Bagdasar Arseni" Emergency Hospital in Bucharest. The traumatic biomechanical conditions were different in the two cases and are presented in the article. Traumatic spondylolisthesis is very rare and usually occurs in competitive sports or road accidents. This has direct forensic implications concerning the analysis of traumatic spondylolisthesis, as well as any traumatic spinal cord injury resulting in neurologic impairment. Symptoms include spinal instability and various neurological syndromes, from simple radiculopathies to cauda equina syndrome. There are usually other thoraco-abdominal injuries associated as well, and treatment generally involves surgical intervention which entails rapid surgical decompression and solid spinal stabilization. © 2012 Romanian Society of Legal Medicine. Source

Stan C.,National Institute of Legal Medicine Mina Minovici | Stan C.,Titu Maiorescu University
Interventional Medicine and Applied Science | Year: 2012

Torture and death in custody have incurred rapid development as juridical subject in recent years in Europe, with the implementation of the European Convention of Human Rights. Evaluation of sufferance severity, which is the consequence of pathology with chronic evolution, the predictability of decompensation of a subclinical pathology, and translating these medical information on a scale measuring the severity of detention consequences, are all challenges for the modern detention healthcare system, in which most allegations of torture are due to lack of appropriate medical treatment administered to inmates. Where ethics are concerned, the main data difficulties are addressed in ethical conflicts between officials and experts of the parties and also between experts and judiciary officials who handle cases of torture or death in detention; this is why standardization is very important in such cases both in clinical expertise and in autopsies or exhumations. © 2012 Akadémiai Kiadó, Budapes. Source

Beuran M.,Emergency Hospital of Bucharest | Beuran M.,Carol Davila University of Medicine and Pharmacy | Negoi I.,Emergency Hospital of Bucharest | Negoi I.,Carol Davila University of Medicine and Pharmacy | And 7 more authors.
Pancreatology | Year: 2015

Background/Objectives The present article summarizes and analyzes the current knowledge about the role of the epithelial to mesenchymal transition (EMT) in the systemic invasiveness of pancreatic cancer. Method An electronic search of PubMed/MEDLINE, EMBASE, and the Web of Science was used to identify relevant original articles and reviews. Results The EMT represents a key step during normal embryogenesis. However, increasing evidence reveals its essential role in the local progression and metastasis of pancreatic cancer. Areas of interest are the cross-linking between cells undergoing the EMT and pancreatic cancer stem cells, and the correlation between the EMT and chemoresistance to standard therapies. During carcinogenesis, malignant pancreatic cells at the primary site acquire the ability to undergo the EMT, a transformation associated with increased mobility. The reverse process at secondary sites, the mesenchymal to epithelial transition (MET), has devastating consequences, allowing neoplastic epithelial cells to invade surrounding tissues and spread to distant sites. Consequences of the EMT are the loss of E-cadherin expression and the acquisition of mesenchymal markers including fibronectin or vimentin. Detailed knowledge of the molecular processes underlying the EMT has opened possibilities for new therapeutic agents. These include an EMT approach for patients with early cancers, to prevent invasion and dissemination, and anti-MET therapy for patients with established metastasis. Conclusions The current literature shows a strong correlation between the EMT and the systemic aggressiveness of pancreatic tumors. Individualized therapy, targeting the process of EMT and its cross-linking with cancer stem cells, may increase survival of patients with pancreatic cancer. © 2015 IAP and EPC. Source

Rusu M.C.,Carol Davila University of Medicine and Pharmacy | Rusu M.C.,Romanian Academy of Sciences | Pop F.,Carol Davila University of Medicine and Pharmacy | Boscu A.L.,Victor Babes University of Medicine and Pharmacy Timisoara | And 4 more authors.
Annals of Anatomy | Year: 2011

The anatomy of the tracheal microinnervation is understudied in humans; the purpose of our study was to fill this gap by working on human adult tracheas, to compare the results with those obtained from animal studies, and to checking whether or not these studies are suitable to be translated from comparative to the human anatomy. The study was designed as a qualitative one. The present work was performed on human adult tracheas dissected out in 15 human adult cadavers. Microdissections were performed in eight tracheas and revealed the outer peritracheal plexus, segmentally supplied and distributed to trachea and esophagus, with longitudinal intersegmentary anastomoses but also with bilateral interrecurrential anastomoses previously undescribed in anatomy. Seven different tracheas were transversally cut and paraffin embedded. Histological stains (HE, toluidine blue, luxol fast blue, Giemsa on tissues and trichrome Gieson) and immunohistochemistry using primary antibodies for nNOS, neurofilament, SMA and the cocktail of citokeratines CK AE1-AE3. +. 8/18 were done. According to the histological individual variation, the neural layers of the posterior wall of the human trachea could be considered as it follows: (a) an outer neural layer, ganglionated, associated with the connective covering layers, adventitia and the posterior fibroelastic membrane (external elastic lamina); (b) a submucosal ganglionated neural layer, mainly with juxtaglandular microganglia that may expand, as glands do, through the outer covering layers; (c) intrinsic nerves of the transverse trachealis muscle; (d) the neural layer intrinsic to the longitudinal elastic band (internal elastic lamina) and supplied from the inner submucosa; (e) the neural plexus of the lamina propria, with scarcely distributed neurons. We also bring here the first evidences for the in vivo nNOS phenotype of mast cells that were identified, but not exclusively, within the trachealis muscle. © 2010 Elsevier GmbH. Source

Malinescu B.,Ilfov Medico Legal Service | Martius E.,National Institute of Legal Medicine Mina Minovici | Pelin A.M.,Al. I. Cuza University
Forensic Science International | Year: 2015

Peroxisomal diseases are rare (1:50,000), genetically determined disorders (autosomal recessive), systemic, multiorgan illnesses with prominent involvement of the nervous system, caused either by the failure to form or to maintain the peroxisome, or by a defect in the function of a single or multiple peroxisomal enzymes [2]. Peroxisomes contain approximately 50 enzymes which are responsible for many metabolic reactions, and play an important role in the oxidation of saturated very-long-chain fatty acids (VLCFA) [1].The authors present the case of a Romanian boy, who died at the age of 1.6 of one of the peroxisomal diseases-Zellweger syndrome. Newborn infants with Zellweger syndrome have a typical dysmorphic facies, neonatal seizures, profound hypotonia, and eye abnormalities. Major abnormalities are present in the liver (fibrotic), kidney (cortical cysts), and brain (lipid-laden macrophages and histiocytes in cortical and periventricular areas, demyelination, centrosylvian polymicrogyria and pachygyria)-cerebro-hepato-renal syndrome (CHRS) (Zellweger) [2]. Infants with Zellweger syndrome rarely live more than a few months [10], but in this case the survival was longer, and the cause of death was not directly the peroxisomal disease but a violent cause of death-mechanical asphyxia with tracheo-bronchial food aspiration. The authors present the results of investigations carried out during the child's life, but also data collected at the autopsy and hystopathological postnecroptic investigations. By presenting this case, the authors wish to bring to your attention a rare pathology in forensic practice by the paradox of finding a common violent cause of death, asphyxia with food aspiration, in a rare metabolic-genetic disease, which is usually fatal by itself. © 2015 Elsevier Ireland Ltd. Source

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