Military Medical Research Center

Romania

Military Medical Research Center

Romania
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Serban C.,Carol Davila University of Medicine and Pharmacy | Mitrea N.,Carol Davila University of Medicine and Pharmacy | Ordeanu V.,Military Medical Research Center
Farmacia | Year: 2012

Hospital sanitary microbiology laboratories perform the sanitary inspection, especially in high-risk wards, control hospital flora contamination, which is often multiresistant, perform the periodic monitoring of staff at risk and the examination of persons outside the institution. Data on chemotherapy, germs and tested samples from a sanitary microbiology laboratory revealed specific issues. The database we acquired includes 35 antibiotics, 13 bacterial strains and 13 types of samples, totaling 43,892 bacterial sensibility tests. In statistical terms, only four antibiotics were effective (over 50%), but they are rarely used in therapy. For all the other antibiotics, resistant and intermediate results have prevailed. Pathogenic flora isolated, identified and tested in the hospital is generally multiresistant and creates the risk of nosocomial infections. The result of in vitro testing of bacterial sensibility to antibiotics is not always consistent with the in vivo results of antibiotherapy, the correlation is mainly statistical, but offers one effective indicator for prescribing antibacterial therapy.


Truta E.,Clinical Emergency Hospital Bucharest | Davitoiu A.M.,Clinical Emergency Hospital for Children Victor Gomoiu Bucharest | Jinescu G.,Clinical Emergency Hospital Bucharest | Mitu A.M.,Individual Cabinet from psychology Ana Mihaela Mitu Bucharest | And 3 more authors.
Revista de Chimie | Year: 2016

The study on the correlation of urinary leaden levels and attention deficit hyperactivity disorder was conducted during 2013 - 2014 and included 50 children from orphanage "SOS Children's Villages" Bucharest divided in two groups: group A included 25 children (12 boys and 13 girls) without an attention deficit and hyperactivity disorder syndrome (ADHD) diagnose and group B included 25 children (14 boys and 11 girls) diagnosed with ADHD. Toxicology Laboratory of Clinical Emergency Hospital Bucharest made leaden determinations using Graphite Tube Atomic Absorbtion technique. The average of leaden level determined in both groups was < 2μg/L, values under the maximum permissible limit (< 10 μg/L). The leaden averages in the two groups do not differ significantly. Children in the study, regardless of the group they were assigned to, were cared for and educated in the same social and ambient environment, coming into contact with the same pollutants from water, air and food, but some have developed ADHD symptoms and others have not been diagnosed with ADHD. The study was unable to establish connection between values and leaden presence of ADHD symptoms.


Ordeanu V.,Military Medical Research Center | Bicheru S.N.,Military Medical Research Center | Necsulescu M.,Military Medical Research Center | Ionescu L.E.,Military Medical Research Center | And 3 more authors.
Revista de Chimie | Year: 2015

"Bio-chem" intentional or unintentional contamination, is a real risk, to which must have effective management to prevent and combat. Decontamination, subsequent chemical and/or biological attaks, terrorist attacks or industrial accidents with bio-chem" agents is the first measure to be applied to protect personnel and the environment, in order to reduce the number of victims and the liquidation of the event. The products used in microbial decontamination are numerous, but very few meet all the requirements conditions of a good decontaminant. Among these, there are a series of new "bio-chem" decontaminant obtained from oxidizing compounds. The most effective substances, selected after making tests in different experimental conditions, can be produced and used for decontamination, in accordance with legal procedures.


Ordeanu V.,Military Medical Research Center | Popescif D.M.,Military Medical Research Center | Dumitrescu G.V.,Military Medical Research Center | Bicheru S.N.,Military Medical Research Center | And 3 more authors.
Revista de Chimie | Year: 2015

Decontamination after biological attacks and I or chemical terrorist attacks or industrial accidents with "bio- chem" agents must be fast and efficient in order to reduce the number of victims and to erase the traces of the event. The decontamination of living or non-living biological agents and toxic chemicals can be achieved by hydrolysis in the different experimental conditions, in particular in an alkaline medium, reaction with amines or ammonia, alcohols and phenols, etc.. and transformation into less toxic degradation products. Intentional or unintentional "bio-chem" contamination, is a real risk, to which must have effective management to prevent and combat. Decontamination is an essential measure to protect the personnel and the environment. The synthesis and testing of new "bio-chem" decontaminant agents, based on quaternary ammonium salts, completes the arsenal of protection from chemical and biological agents. The synthesized substances that were tested by us for "bio-chem" decontamination are effective due to their specific action, less toxicity, msy to prepare and use and low costs. The most efficient substances that were selected can be produced and used for decontamination, in accordance with the law.

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