PubMed | Henan University of Traditional Chinese Medicine, U.S. Center for Disease Control and Prevention, Shenzhen University, Military Hospital of Henan Province and Zhengzhou University
Type: Journal Article | Journal: Biomedical and environmental sciences : BES | Year: 2015
To investigate the association between low-density lipoprotein receptor-related protein 5 (LRP5) variants (rs12363572 and rs4930588) and type 2 diabetes mellitus (T2DM) in Han Chinese.A total of 1842 T2DM cases (507 newly diagnosed cases and 1335 previously diagnosed cases) and 7777 controls were included in this case-control study. PCR-RFLP was conducted to detect the genotype of the two single nucleotide polymorphisms (SNPs). Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated to describe the strength of the association by logistic regression.In the study subjects, neither rs12363572 nor rs4930588 was significantly associated with T2DM, even after adjusting for relevant covariates. When stratified by body mass index (BMI), the two SNPs were also not associated with T2DM. Among the 3 common haplotypes, only haplotype TT was associated with reduced risk of T2DM (OR 0.820, 95% CI 0.732-0.919). In addition, rs12363572 was associated with BMI (P<0.001) and rs4930588 was associated with triglyceride levels (P=0.043) in 507 newly diagnosed T2DM cases but not in healthy controls.No LRP5 variant was found to be associated with T2DM in Han Chinese, but haplotype TT was found to be associated with T2DM.
PubMed | Shenzhen University, Zhengzhou University, Military Hospital of Henan Province, Southern Medical University and 2 more.
Type: Journal Article | Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme | Year: 2015
The objective of the present study was to summarize the prevalence and influencing factors of metabolically healthy obese (MHO) and metabolically obese but normal weight (MONW) among people 18 years old in the general population worldwide. We searched for studies of the prevalence of MHO and MONW published in English and Chinese up to October 2013. Pooled prevalence estimates were calculated by a random-effects model according to a Q test. The effects of gender, region, age, sample size, smoking, and alcohol consumption on MHO and MONW were analyzed. Differences between subgroups were assessed by chi-square test. Publication bias was estimated by Eggers test. Studies of MHO and MONW showed heterogeneity (I(2)=99.4% and I(2)=99.7%, respectively). The overall prevalence of MHO and MONW was 7.27% (95% CI 5.92-8.90%) and 19.98% (95% CI 16.54-23.94%), respectively. American populations had the highest MHO prevalence and European populations the highest MONW prevalence. Different patterns of MHO and MONW were observed in the subgroup analysis with respect to gender, age, sample size, smoking, alcohol consumption, and metabolically healthy criteria. The prevalence of both MHO and MONW were affected by gender, region, age, sample size, smoking, alcohol consumption, and metabolically healthy criteria, but studies showed high heterogeneity.
PubMed | Zhoukou City Central Hospital, Shenzhen University, Military Hospital of Henan Province and Zhengzhou University
Type: | Journal: Journal of diabetes | Year: 2016
The aim of the present study was to estimate trends in the prevalence of type 2 diabetes mellitus (T2DM) in adults in China.A systematic search was conducted for studies of T2DM prevalence in adults in China from 2000 to 2014. Pooled prevalence was calculated by a random-effects model. Subgroup and sensitivity analyses were performed. Chi-squared and Cochran-Mantel-Haenszel tests were used to assess differences among subgroups and pooled prevalence, respectively.Forty-six studies (data from 1995 to 2014; 1463079 adults) were included in the meta-analysis. The overall prevalence of T2DM was 7.9%. The pooled prevalence overall and by location (urban and rural), gender (male and female), and age category (18-39, 40-59, and 60years) was 4.5%, 5.1% and 3.0%, 4.0% and 4.2%, and 1.4%, 5.0%, and 10.3%, respectively, from 1995 to 1999; 6.6%, 9.3% and 5.6%, 7.4% and 7.5%, and 1.8%, 5.9%, and 12.4%, respectively, from 2000 to 2004; 10.3%, 11.8% and 6.8%, 10.0% and 8.6%, and 2.8%, 10.3%, and 20.0%, respectively, from 2005 to 2009; and 8.3%, 12.5% and 7.6%, 8.6% and 8.0%, and 3.5%, 8.5%, and 15.3%, respectively, from 2010 to 2014. The prevalence increased from 5.8% to 11.6% with per-capita gross domestic product and differed by diagnostic criteria.There was a trend of increasing prevalence of T2DM in adults in China from 1995 to 2009, with a decrease in 2010-14 and a greater increase over time in urban versus rural areas, males versus females, and older versus younger adults.
Wang C.-J.,Zhengzhou University |
Li Y.-Q.,Zhengzhou University |
Wang L.,Zhengzhou University |
Li L.-L.,Zhengzhou University |
And 4 more authors.
PLoS ONE | Year: 2012
Background: Dyslipidemia is an extremely prevalent but preventable risk factor for cardiovascular disease. However, many dyslipidemia patients remain undetected in resource limited settings. The study was performed to develop and evaluate a simple and effective prediction approach without biochemical parameters to identify those at high risk of dyslipidemia in rural adult population. Methods: Demographic, dietary and lifestyle, and anthropometric data were collected by a cross-sectional survey from 8,914 participants living in rural areas aged 35-78 years. There were 6,686 participants randomly selected into a training group for constructing the artificial neural network (ANN) and logistic regression (LR) prediction models. The remaining 2,228 participants were assigned to a validation group for performance comparisons of ANN and LR models. The predictors of dyslipidemia risk were identified from the training group using multivariate logistic regression analysis. Predictive performance was evaluated by receiver operating characteristic (ROC) curve. Results: Some risk factors were significantly associated with dyslipidemia, including age, gender, educational level, smoking, high-fat diet, vegetable and fruit intake, family history, physical activity, and central obesity. For the ANN model, the sensitivity, specificity, positive and negative likelihood ratio, positive and negative predictive values were 90.41%, 76.66%, 3.87, 0.13, 76.33%, and 90.58%, respectively, while LR model were only 57.37%, 70.91%, 1.97, 0.60, 62.09%, and 66.73%, respectively. The area under the ROC cure (AUC) value of the ANN model was 0.86±0.01, showing more accurate overall performance than traditional LR model (AUC = 0.68±0.01, P<0.001). Conclusion: The ANN model is a simple and effective prediction approach to identify those at high risk of dyslipidemia, and it can be used to screen undiagnosed dyslipidemia patients in rural adult population. Further work is planned to confirm these results by incorporating multi-center and longer follow-up data. © 2012 Wang et al.
Wang J.,Zhengzhou University |
Hu F.,Harbin Medical University |
Feng T.,Military Hospital of Henan Province |
Zhao J.,Military Hospital of Henan Province |
And 6 more authors.
BMC Medical Genetics | Year: 2013
Background: Associations between transcription factor 7-like 2 (TCF7L2) polymorphisms and type 2 diabetes mellitus (T2DM) have been evaluated extensively in multiple ethnic groups. TCF7L2 has emerged as the strongest T2DM susceptibility gene in Europeans, but the findings have been inconsistent in the Chinese population. The purpose of this meta-analysis was to evaluate the associations between TCF7L2 single nucleotide polymorphisms (SNPs) and T2DM risk in the Chinese population.Methods: We performed searches in the PubMed, EMBASE, Cochrane, and Chinese databases (CNKI, CQVIP and Wanfang databases) for literature published from January 2007 to February 2012. We reviewed all relevant articles on TCF7L2 polymorphisms and susceptibility to T2DM in the Chinese population written in English and Chinese. Two reviewers extracted data independently using a standardized protocol, and any discrepancies were adjudicated by a third reviewer. Fixed-effects and random-effects meta-analyses were performed to pool the odds ratios (ORs). Publication bias and heterogeneity were examined.Results: A total of 21 articles were confirmed to be eligible for and included in this meta-analysis: 7 (with 3942 cases and 3502 controls) concerning rs11196218 (IVS-/+4G>A), 8 (with 3377 cases and 2975 controls) concerning rs290487 (IVS3-/+C>T), and 14 (with 7902 cases and 7436 controls) concerning rs7903146 (IVS3-/+C>T). Overall, the results showed a significant association between rs7903146 and T2DM risk. The pooled ORs were 1.54 for the comparison of T and C alleles (95% CI [confidence interval]: 1.37-1.74, p = 1.47 × 10-12, I2 = 25.20%) and 1.56 for TC heterozygotes and CC homozygotes (95% CI : 1.38-1.76, p = 8.25 × 10-9, I2 = 21.00%). The rs11196218(IVS4G>A) and rs290487 (IVS3C>T) SNPs were not associated with T2DM risk.Conclusions: The rs7903146 SNP of the TCF7L2 gene is associated with increased susceptibility to T2DM in the Chinese population as a whole as well as northern Chinese and southern Chinese as subgroups. © 2013 Wang et al.; licensee BioMed Central Ltd.
PubMed | Shenzhen University, Military Hospital of Henan Province and Zhengzhou University
Type: Journal Article | Journal: Journal of human hypertension | Year: 2016
Limited information is available on the prevalence of obesity and high blood pressure (HBP) in rural China. We conducted a cross-sectional survey in a rural adult Chinese population during July to August of 2007 and 2008. The relationship between various obesity categories and HBP was analysed by gender for 20194 participants. Obesity categories were classified as general and central obesity in terms of body mass index (BMI) and waist circumference (WC), respectively; cross-classification of BMI and WC created another four groups: both BMI and WC normal (BNWN), BMI obesity and WC normal (BOWN), BMI normal and WC obesity (BNWO), and both BMI and WC obesity (BOWO). The rates of HBP for BNWN, BOWN, BNWO and BOWO groups were 20.8, 63.3, 39.8 and 48.7%, respectively, for men and 20.1, 28.0, 34.7 and 54.2%, respectively, for women. As compared with BNWN group, the adjusted odds ratio (OR) and 95% confidence interval (CI) of BOWN and BOWO for having HBP in men were 6.227 (2.712-14.300) and 4.842 (4.036-5.808), respectively. As compared with BNWN women, BNWO and BOWO women showed increased risk of HBP (adjusted OR=1.342, 95%CI=1.139-1.581 and adjusted OR=4.530, 95%CI=4.004-5.124, respectively). The prevalence of general and central obesity was strongly related to HBP. Men with obese BMI but normal WC may be at increased risk of HBP. Women should pay more attention to changes in visceral adipose distribution and keep both BMI and WC values within normal ranges to reduce obesity-related health problems.
PubMed | Chinese University of Hong Kong, Shenzhen University, Military Hospital of Henan Province, Zhengzhou University and Guiyang Medical University
Type: Journal Article | Journal: Journal of diabetes investigation | Year: 2016
To clarify the association of the hypertriglyceridemic waist phenotype and type 2 diabetes mellitus among adults in China.In the present case-control study, we included 1,685 patients with type 2 diabetes mellitus and 7,141 normal glucose-tolerant controls from the Henan Province of China in 2011. Elevated waist circumference (GW) was defined as 90 cm for men and 80 cm for women. Hypertriglyceridemia (HT) was defined as >1.7 m mol/L triglycerides (TG) level. The association of hypertriglyceridemic waist phenotype and type 2 diabetes mellitus was investigated by sex, body mass index, physical activity, and family history of diabetes.Cases and controls differed in age, waist circumference (WC), weight, TG level, fasting glucose, body mass index, smoking status, diabetic family history, physical activity and hypertriglyceridemic waist phenotype (P < 0.05), but not alcohol drinking (P = 0.63). In the overall sample, as compared with the phenotype of normal TG level and normal WC (NTNW), normal TG level/enlarged WC (NTGW), elevated TG level/normal WC (HTNW) and elevated TG level/enlarged WC (HTGW) were associated with type 2 diabetes mellitus (odds ratio 4.14, 2.42 and 6.23, respectively). Only HTGW was consistently associated with risk of type 2 diabetes mellitus, with or without adjustment. The strongest relationship between HTGW and type 2 diabetes mellitus was for subjects with body mass index <24.0 kg/m(2) (odds ratio 6.54, 95% confidence interval 4.22-10.14) after adjustment for cofounding variables.HTGW was stably and significantly associated with risk of type 2 diabetes mellitus in adult Chinese.
PubMed | Shenzhen University, Henan University of Traditional Chinese Medicine, Zhengzhou University and Military Hospital of Henan Province
Type: | Journal: Journal of diabetes | Year: 2017
Low-density lipoprotein receptor-related protein 5 (LRP5) plays an important role in glucose and cholesterol metabolism, so a cohort study was used to evaluate the association of LRP5 variants and incidence of type 2 diabetes mellitus (T2DM) in a rural adult Chinese population.A total of 7751 subjects 18years old and without T2DM underwent genotyping at baseline; 6326 subjects (81.62%) were followed-up, with 5511 eligible for this analysis. The same questionnaire interview, anthropometric and blood biochemical examinations were performed at baseline and follow-up. An association analysis was performed for 5 SNPs and haplotypes of LRP5.On Cox proportional hazards testing of the three different genetic models, no significant association had been found between T2DM and LRP5 after adjusting for potential risk factors (P>0.05). But the incidences of T2DM of LRP5 mutational genotypes in overweight/obesity population were higher than that of normal weight population. And under the dominant model, risk of T2DM was increased with the interaction of rs11228303 and the waist-to-height ratio (WHtR) adjusted for baseline age, sex and family history of T2DM [the synergy index SI= 4.172(1.014-17.166)], and BMI [SI= 3.237(1.102-9.509)]. Furthermore, A allele of rs3758644 was related with decreased fasting plasma insulin and HOMA- level, and T allele of rs12363572 was related with increased HDL-C level of new-onset diabetes patients (P<0.05).The risk of T2DM may be associated with the interactions of LRP5 gene and overweight and obesity. LRP5 polymorphism is related -cell function and lipid metabolism.
PubMed | Shenzhen University, Henan University of Traditional Chinese Medicine, Zhengzhou University and Military Hospital of Henan Province
Type: Journal Article | Journal: Biomedical and environmental sciences : BES | Year: 2016
This cohort study was designed to evaluate the association of transcription factor 7-like 2 (TCF7L2) and proglucagon gene (GCG) variants with disordered glucose metabolism and the incidence of type 2 diabetes mellitus (T2DM) in a rural adult Chinese population. A total of 7,751 non-T2DM participants 18 years old genotyped at baseline were recruited. The same questionnaire interview and physical and blood biochemical examinations were performed at both baseline and follow-up. During a median 6 years of follow-up, T2DM developed in 227 participants. After adjustment for potential contributory factors, nominally significant associations were seen between TT genotype and the recessive model of TCF7L2 rs7903146 and increased risk of T2DM [hazard ratio (HR)=4.068, 95% confidence interval (CI): 1.270-13.026; HR=4.051, 95% CI: 1.268-12.946, respectively]. The TT genotype of rs7903146 was also significantly associated with higher fasting plasma insulin level and the homeostasis model assessment of insulin resistance in case of new-onset diabetes. In addition, the TCF7L2 rs290487 TT genotype was associated with abdominal obesity and the GCG rs12104705 CC genotype was associated with both general obesity and abdominal obesity in case of new-onset diabetes.
PubMed | Military Hospital of Henan Province, Henan University of Traditional Chinese Medicine, Zhengzhou University, Henan Armed Police Corps Hospital and Shenzhen University
Type: Journal Article | Journal: Nutrients | Year: 2015
We aimed to investigate the associations of polymorphisms in Canonical Wnt/-catenin pathway (WNT) signaling genes (including low-density lipoprotein-related protein 5 [LRP5] and transcription factor 7-like 2 [TCF7L2] gene) and the downstream gene glucagon (GCG) and risk of type 2 diabetes mellitus (T2DM) in a Han Chinese population. We genotyped the single nucleotide polymorphisms (SNPs) for LRP5, TCF7L2 and GCG gene were genotyped in 1842 patients with T2DM and 7777 normal glucose-tolerant healthy subjects. We used multifactor dimensionality reduction (MDR) and multiplicative logistic regression adjusting for sex, age, anthropometric measurements and lipid levels to investigate the gene-gene interactions for the risk of T2DM. Among the five SNPs in LRP5, the recessive model of rs7102273 and the haplotype GCTCC were associated with T2DM risk; the haplotype GCTTC was associated with decreased risk. For TCF7L2, the rs11196218 genotype GA and the haplotype CCG, TTG, TTA were associated with T2DM risk; whereas, the haplotype CTG and TCG were associated with decreased risk. Both MDR and multiplicative logistic regression revealed potential gene-gene interactions among LRP5, TCF7L2, and GCG associated with T2DM. The WNT signaling pathway may play a significant role in risk of T2DM in Han Chinese people.