MIKI Corporation

Kita-ku, Japan

MIKI Corporation

Kita-ku, Japan
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Kubo K.,Gifu University | Koido A.,Gifu University | Kitano M.,MIKI Corporation | Yamamoto H.,MIKI Corporation | Saito M.,MIKI Corporation
Journal of Nutritional Science and Vitaminology | Year: 2016

As bioactive ingredients of functional foods, dietary fiber and wheat albumin (WA) are known to suppress hyperglycemia in patients with type 2 diabetes mellitus. The combined effects of these bioactive ingredients were examined using an animal model of type 2 diabetes mellitus. First, oral starch tolerance tests (OSTTs) with the simultaneous intake of a dietary fiber mixture (DF) and WA were performed as an acute study. Male Goto-Kakizaki rats received a soluble starch solution [700 mg/kg body weight (bw)] containing DF and/or WA (each 300 mg/kg bw). In these OSTTs, the combined intake of DF and WA suppressed hyperglycemia much more effectively than each separate intake. Second, in a chronic intake study, diets containing DF and/or WA were administered to male Zucker diabetic fatty rats over 84 d. The combined effects of DF and WA were not observed in gly-cosylated hemoglobin concentration levels or fasting blood glucose levels, but appeared as an improvement in liver lipid contents. Variations in the liver lipid contents were similarly reflected in those of the plasma lipid concentrations. In conclusion, this study found that the simultaneous intake of bioactive DF and WA improved the postprandial hyperglycemia and the chronic lipid metabolism disorders in rat models of type 2 diabetes mellitus. © 2016, Center for Academic Publications Japan. All rights reserved.


Kayano S.-I.,Kio University | Kikuzaki H.,Nara Women's University | Hashimoto S.,Osaka City University | Kasamatsu K.,Osaka City University | And 3 more authors.
Phytochemistry Letters | Year: 2014

The chemical structures of 9 compounds isolated from the dried fruits of Prunus domestica L. were elucidated on the basis of NMR and MS analyses. Each isolated compound was determined to be scopolin (1), (3-O-cis-p-coumaroyl- β-d-fructofuranosyl)-(2→1)-α-d-glucopyranoside (2), 1S-(4-β-d-glucopyranosyl-3-methoxyphenyl)-2R-[4-(3-hydroxypropyl) -2-methoxyphenoxy]-1,3-propanediol (3), β-d-glucopyranosyl 9-carboxy-8-hydroxy-2,7-dimethyl-2E,4E-nonadienate (4), β-d-glucopyranosyl 7-carboxy-2-methyl-2E,4E-octadienate (5), 8-hydroxy-2,7-dimethyl-2E,4E- decadienedioic acid 1-β-d-glucopyranyl ester 10-methyl ester (6), (3-O-trans-p-coumaroyl-β-d-fructofuranosyl)-(2→1)-α-d- glucopyranoside (7), β-d-glucopyranosyl cinnamate (8), and 2,7-dimethyl-2E,4E-octadienedioic acid (9), respectively. Compounds 2, 3, 4, 7, 8, and 9 were isolated from P. domestica L. for the first time, and compounds 5 and 6 were novel glucosyl terpenates. © 2014 Phytochemical Society of Europe.


Kobayakawa A.,MIKI Corporation | Suzuki T.,MIKI Corporation | Ikami T.,MIKI Corporation | Saito M.,MIKI Corporation | And 2 more authors.
Journal of Dietary Supplements | Year: 2013

A double-blind, randomized, controlled study was conducted to evaluate the effects of a moderate amount of dietary fiber intake on fasting plasma glucose level and physical characteristics in Japanese men with mild hyperglycemia and visceral fat obesity. Thirty men with mild hyperglycemia (>5.6 mmol/L) and visceral fat accumulation (>100 cm2) ingested 7.5 g/day of dietary fiber for 12 weeks. An abdominal computed tomography scan was performed at baseline and at week 12. Blood was drawn every 4 weeks. In the test food group, fasting plasma glucose level was reduced with time, and the difference between the test food group and placebo group was statistically significant at week 12. Body weight and body mass index were also reduced with time, but visceral and subcutaneous fat areas did not change significantly during the study period. The results suggest that even a moderate amount of dietary fiber intake may be beneficial for managing the fasting plasma glucose level concomitant with insulin resistance, body weight, and body mass index in Japanese men with mild hyperglycemia and visceral fat obesity. © 2013 Informa Healthcare USA, Inc.


Hara Y.,Gifu University | Mizukawa H.,Gifu University | Yamamoto H.,MIKI Corporation | Ikami T.,MIKI Corporation | And 3 more authors.
Bioscience, Biotechnology and Biochemistry | Year: 2013

L-Arabinose is a useful sugar in the food industry. We demonstrate here simple methods for refining arabinan polysaccharides by alcohol extraction from prune, Prunus domestica L., as a source of L-arabinose. Alcohol-soluble polysaccharides were purified from a solution of prune extracted by 80% ethanol. After fractionating the polysaccharides by ion-exchange chromatography, arabinans were identified as mainly constituted by (1→5)-linked arabinofuranosyl units.


Fujii T.,MIKI Corporation | Okuda T.,MIKI Corporation | Yasui N.,Mukogawa Women's University | Wakaizumi M.,MIKI Corporation | And 2 more authors.
Journal of Functional Foods | Year: 2013

Amla (Emblica officinalis Gaertn.) is a rich dietary source of vitamin C, minerals and amino acids, and also contains a wide variety of phenolic compounds. Amla has also been used as a principal constituent of many preparations of Ayurved, the Indian system of traditional medicine. Gelatin hydrolysate, also known as collagen peptide as a functional ingredient, is obtained from animal hide or fish scales. Ingestion of gelatin or collagen peptide affects various functions of the body, including bone, the achilles tendon, and skin. However, there are few data on the effects of amla extract and collagen peptide on photoaging in vivo. In the present study, therefore, we administered amla extract and/or collagen peptide to hairless mice that were repeatedly exposed of UVB irradiation, and examined the resulting effects on photoaging. Amla extract and collagen peptide suppressed the formation of 8-OHdG-positive cells and epidermal hyperplasia, and controlled skin hydration, thus reducing skin wrinkle formation in the mice. Collagen peptide, but not amla extract, also enhanced the production of collagen. We demonstrated that amla extract and collagen peptide exerted an additive effect in ameliorating skin dehydration and wrinkle formation, suggesting that they were able to attenuate photoaging effectively in UVB-irradiated hairless mice. © 2012 Elsevier Ltd.


Fujii T.,MIKI Corporation | Ikeda K.,Mukogawa Women's University | Saito M.,MIKI Corporation
Bioscience, Biotechnology and Biochemistry | Year: 2011

The compounds present in rose hips exerting an inhibitory action against melanogenesis in B16 mouse melanoma cells were investigated by dividing an aqueous extract of rose hips (RE) into four fractions. The 50% ethanol eluate from a DIAION HP-20 column significantly reduced the production of melanin and was mainly composed of procyanidin glycosides. We also found that this 50% ethanol eluate reduced the intracellular tyrosinase activity and also had a direct inhibitory effect on tyrosinase obtained as a protein mixture from the melanoma cell lysate. We also investigated the effect of orally administering RE on skin pigmentation in brown guinea pigs, and found that the pigmentation was inhibited together with the tyrosinase activity in the skin. These data collectively suggest that proanthocyanidins from RE inhibited melanogenesis in mouse melanoma cells and guinea pig skin, and could be useful as a skin-whitening agent when taken orally.


Yamamoto H.,MIKI Corporation | Yamamoto H.,Shiga University of Medical Science | Morino K.,Shiga University of Medical Science | Mengistu L.,Shiga University of Medical Science | And 4 more authors.
Oxidative Medicine and Cellular Longevity | Year: 2016

Amla is one of the most important plants in Indian traditional medicine and has been shown to improve various age-related disorders while decreasing oxidative stress. Mitochondrial dysfunction is a proposed cause of aging through elevated oxidative stress. In this study, we investigated the effects of Amla on mitochondrial function in C2C12 myotubes, a murine skeletal muscle cell model with abundant mitochondria. Based on cell flux analysis, treatment with an extract of Amla fruit enhanced mitochondrial spare respiratory capacity, which enables cells to overcome various stresses. To further explore the mechanisms underlying these effects on mitochondrial function, we analyzed mitochondrial biogenesis and antioxidant systems, both proposed regulators of mitochondrial spare respiratory capacity. We found that Amla treatment stimulated both systems accompanied by AMPK and Nrf2 activation. Furthermore, we found that Amla treatment exhibited cytoprotective effects and lowered reactive oxygen species (ROS) levels in cells subjected to t-BHP-induced oxidative stress. These effects were accompanied by increased oxygen consumption, suggesting that Amla protected cells against oxidative stress by using enhanced spare respiratory capacity to produce more energy. Thus we identified protective effects of Amla, involving activation of mitochondrial function, which potentially explain its various effects on age-related disorders. © 2016 Hirotaka Yamamoto et al.


Trademark
Miki Corporation | Date: 2011-01-18

Brooches; Clocks and watches; Costume jewelry; Earrings; Gemstones; Jewelry and imitation jewelry; Necklaces; Pendants; Personal ornaments of precious metal; Rings; Tie pins.


Trademark
Miki Corporation | Date: 2010-07-06

Clocks and watches; Gemstones; Jewelry and imitation jewelry; Personal ornaments of precious metal.


PubMed | MIKI Corporation
Type: Journal Article | Journal: Journal of dietary supplements | Year: 2013

A double-blind, randomized, controlled study was conducted to evaluate the effects of a moderate amount of dietary fiber intake on fasting plasma glucose level and physical characteristics in Japanese men with mild hyperglycemia and visceral fat obesity. Thirty men with mild hyperglycemia (>5.6 mmol/L) and visceral fat accumulation (>100 cm) ingested 7.5 g/day of dietary fiber for 12 weeks. An abdominal computed tomography scan was performed at baseline and at week 12. Blood was drawn every 4 weeks. In the test food group, fasting plasma glucose level was reduced with time, and the difference between the test food group and placebo group was statistically significant at week 12. Body weight and body mass index were also reduced with time, but visceral and subcutaneous fat areas did not change significantly during the study period. The results suggest that even a moderate amount of dietary fiber intake may be beneficial for managing the fasting plasma glucose level concomitant with insulin resistance, body weight, and body mass index in Japanese men with mild hyperglycemia and visceral fat obesity.

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