Singh V.K.,DrKNMIET |
Sharma H.,MIET |
Singh S.K.,IET |
Chemical Biology and Drug Design | Year: 2013
A series of pyrido-quinazolines have been synthesised, characterized, and tested for their in vitro epidermal growth factor receptor (EGFR) tyrosine kinase inhibitory activity. The compounds were prepared from Alkylideno/arylideno-bis-ureas. Their final structure of the compounds was elucidated on the basis of spectral studies (IR, 1H NMR, FT-IR, and EI-MS). The cellular EGFR internalization response of selected compounds was evaluated using HeLa cells. Most of the synthesized compounds displayed potent EGFR-TK inhibitory activity and structurally halogenated derivatives had a pronounced effect in inhibiting EGFR internalization. © 2013 John Wiley & Sons A/S.
Pandey K.,M.I.E.T |
Sharma P.K.,M.I.E.T |
Dudhe R.,M.I.E.T |
Dudhe R.,Uttarakhand Technical University
Asian Journal of Pharmaceutical and Clinical Research | Year: 2012
The present study was conducted to evaluate the antioxidant and anti-inflammatory activity by Parthenium hysterophorus Linn. Antioxidant activity of ethanolic extract leaves of Parthenium hysterophorus Linn was studied by using in-vitro model i.e. DPPH (1, 1-diphenyl picrylhyrazyl) method. DPPH free radical scavenging method was studied by taking various concentrations of test compound (10-100 μg/ml) in the methanol and 1 ml of each concentration was added to 1ml of 0.1mM solution of DPPH and after 30 mins its absorbance was taken at 517 nm. Acute oral toxicity was studied at a dose of 2000 mg/kg body weight (OECD-425), so this dose was considered as a therapeutic dose. The anti-inflammatory activity was done by in-vivo model i.e. the carrageenan induced rat paw edema model, this extract reduced carrageenan induced rat paw edema in a dose dependent manner, achieving high degree of antioxidant and anti-inflammatory activity using standard ascorbic acid and Indomethacin. The study shows that Parthenium hysterophorus Linn shows a significant antioxidant and anti-inflammatory activity at a dose of 200 mg/kg. It shows potent inhibition in inflammation after 30 min of dosing in rats as compared to control group, and standard group, further increase in dose i.e. 400 mg/kg it shows ulcerogenic responses.
Proceedings of the International Astronautical Congress, IAC | Year: 2013
The static operation of an EmDrive microwave thruster has once again been demonstrated by the Chinese experimental work reported in REF 1. The work repeats and enhances results obtained in earlier UK experiments, REF 2, and confirms the direct relation between specific thrust and Q factor of the cavity. This paper considers the dynamic operation of a thruster with the very high Q factors obtained when a cavity employs superconducting technology. The very high specific thrusts resulting from such second generation (2G) devices must be subject to the law of conservation of energy. It follows therefore, that there must be a mechanism which limits the acceleration of any vehicle propelled by a 2G EmDrive thruster. A mathematical model of a 2G thruster is described which illustrates such a mechanism. The results from the model illustrate the Doppler changes, which occur when a thruster is subject to acceleration. For Q factors around 1 × 109, the total Doppler shift moves the frequency outside the narrow resonant bandwidth of the cavity. This causes the loaded Q of the cavity, and thus the specific thrust, to decrease and therefore limits the acceleration. A technique, employing pulse operation and dynamic control of the cavity length, is described which enables partial compensation for the effect. The resulting thruster design, employing YBCO superconducting walls and liquid hydrogen cooling, achieves a specific thrust of 1 Tonne per kW, provided the acceleration is limited 0.5m/s/s. This low acceleration rate is compatible with primary in-orbit propulsion applications, and will be particularly suitable for deep space missions. For launch vehicles, the acceleration limitation is no obstacle; as a flight profile is proposed where high velocity is only achieved once clear of the atmosphere. Indeed the reusable, EmDrive propelled carrier vehicle itself, is only used to lift the payload to geostationary altitude, where an expendable propulsion module is used to provide orbital velocity. The resulting costs to geostationary orbit are predicted to be 130 times lower, when compared to current launch vehicles. Copyright ©2013 by the International Astronautical Federation.
IET Conference Publications | Year: 2012
Our experience suggests that an organisations' ability to solve their own problems are indicative of how likely they are to improve their overall performance. Many organisations deal with their problems in an order of priority, which is of course a highly effective method of tackling the right things. This can be negatively impacted however if a 'band-aid' approach affects the items on the priority list. Additionally, employing a one-size-fits-all approach to tackling problems often leads either to the simple problems becoming over-bureaucratised or the complex problems not being sufficiently analysed to fully understand their contributing factors. A proportionate approach to problem solving applies the appropriate level of rigour required to ensure that each problem is fully resolved, with the minimum amount of effort.
IET Conference Publications | Year: 2013
This paper describes Vattenfall's long term platform which is intended to cope with the quantity and rate of change of innovation driven by new Regulatory requirements and Smart Grid developments.
Kumar N.,Bhagwant University |
International Journal of Pharma and Bio Sciences | Year: 2016
Trichosanthes dioica seeds are mentioned in various traditional texts as a drug used for vermicidal anthelmintic, insecticidal, sedative, diuretic, demulcent, and expectorant purpose ethnopharmacologically. Objective of the present study was investigation of anthelmintic activity of different extracts of Trichosanthes dioica seeds. Annelids, Pheretima posthuma and nematodes, Ascaridia galli were used to carry out experiments for anthelmintic activity. Piperazine citrate was used as a standard. Time required for paralysis and death (lethal time) of worms were noted for each sample of T. dioica extracts and standard. The results demonstrated that treatment with T. dioica seeds extract significantly (P < 0.05- P < 0.01) paralyzed and killed both of the worms, A. galli and earthworms. The activity was found to be increased with dose. Ethanol and ethyl acetate extracts activity at 60 mg/ml concentration were comparable to the well known anthelmintic agent Piperazine citrate (10 mg/ml). In conclusion, the use of the seeds of T. dioica as an anthelmintic has been confirmed and further studies are suggested to isolate the active principles responsible for the activity.
Rai S.,MIET |
Conference Proceeding - 2015 International Conference on Advances in Computer Engineering and Applications, ICACEA 2015 | Year: 2015
This paper proposed a new algorithm to find a minimum spanning tree of an undirected weighted graph graph. This new algorithm provides a fresh approach to produce a minimum spanning tree. A minimum spanning tree is a sub graph of any undirected weighted graph that gives the minimal cost valued edges to reach every node of any graph. The proposed algorithm is named as RAY algorithm for determining the minimum spanning tree. We named this new algorithm as RAY, as it gives a new ray of hope in the field of graphs that can be used as a better option for finding the minimum spanning tree of any undirected weighted graph with less duration of time as well as with an easy approach. RAY has less complexity with respect to time for finding the minimum spanning tree of any graph in comparison to other algorithms like prim's algorithm and Kruskal's algorithm which are mostly used to find a minimum spanning tree of the graph. RAY algorithm select any one node of the given graph as a root node and then it joins every edge connected to that node, which do not form any cycle in the graph. This process is repeated until we traverse each node of the graph and the edges those forms cycle during this process are stored separately. Now only these separately stored edges are traversed and we check in the graph for maximum weighted edge from the edges that are coming in the cycle which is formed due that particular separately stored edge. If there is any edge in the cycle which is greater in weigh than that of separately stored edge then we discarded maximum weighted edge and the new edge which we stored separately is taken into the minimum spanning tree. This same procedure is repeated for each edge that we stored separately. At the end of this procedure we get a tree which is the minimum spanning tree of the given graph by using RAY algorithm. © 2015 IEEE.
Kumar N.,Galgotias University |
Bhatnagar A.,MIET |
Dudhe R.,Galgotias University
Arabian Journal of Chemistry | Year: 2013
A novel series of 3-(4, 5-dihydro-1-phenyl-5-substituted phenyl-1H-pyrazol-3-yl)-2H-chromen-2-one derivatives were synthesized. In the first step salicylaldehyde was reacted with ethylacetoacetate at room temperature by stirring which gives compound (I). Compound (I) when refluxed with substituted benzaldehyde and diethylamine in the presence of n-butanol for 4-5 h gives substituted derivatives (IIa-d). Compounds synthesized in step 2 when refluxed with phenyl hydrazine in the presence of pyridine for 6-7 h gives the title compounds (IIIa-d). All the synthesized compounds were sent to NCI for anticancer activity. Synthesized compounds were tested for anticancer activity against 60 different cell lines. From the data thus obtained it was observed that simple coumarin ring derivatives were more effective in inhibiting the growth of cancerous cell lines, than coumarin-pyrazoline derivatives. Among all the synthesized compounds, irrespective of compounds having simple coumarin ring and coumarin-pyrazoline combination, compounds IIa-c, IIIb and IIId were potent anticancer agents. Compounds were active for the single dose therapeutic program at the dose of 1.00E-5 molar concentration. The main anti cancer activity is assumed to be due to the presence of the lactone structure in coumarin moiety. © 2013.
Engineering and Technology | Year: 2014
Some of the letters addressed to The Editor, E&T, are discussed. Brian Highe, in his letter, questions on Dickon Ross's editor's letter in the February issue of E&T, and poses several questions about the apparently utopian scene portrayed on the front cover. A letter by Mike Pannell discusses Dennis Sharp's letter about his unsatisfactory experience with mains LED lamps in a new house (February 2014) typifies the problems consumers face when trying to make good environmental decisions. Ian Griffiths, in his letter, is disappointed by Derek Salkeld's Comment column on risk management in the February 2014 issue. He says that the author only describes a process that enables project managers to make an estimate of the value of contingency, and does not cover any of the techniques that risk managers use to mitigate the identified risks and ultimately enable project managers to make timely decisions to maintain project schedules.
IET Conference Publications | Year: 2014
For many years now, the accuracy of data used for thermal evaluation of insulating materials and systems has been grossly impaired by systematic errors inherent in the degradation process itself. The most significant of these are the errors due to temperature variation within the oven chamber used for thermal ageing experiments. It is important to be able to declare within acceptable tolerances that the temperatures reported are actually those which the test materials were subjected in the course of ageing. Not only do test materials suffer wide variations about the nominal average temperature setting of the oven, they are also exposed to unknown temperatures that may be above or below the average value as the temperature profile within the oven is non-uniform. This becomes imperative when accurate comparison is required between two or more alternatives. This paper describes the improved processes and testing procedures required to address the problem.