Middle East Technical University is a public technical university located in Ankara, Turkey. The university puts special emphasis on research and education in engineering and natural science, offering about 40 undergraduate programs within 5 faculties, and 97 masters and 62 doctorate programs within 5 graduate schools. The main campus of METU spans an area of 11,100 acres , comprising, in addition to academic and auxiliary facilities, a forest area of 7,500 acres , and the natural lake Eymir. METU has more than 95,000 alumni worldwide. The official language of instruction at METU is English.Over one third of the 1,000 highest scoring students in the national university entrance examination choose to enroll in METU; and most of its departments accept the top 0.1% of the nearly 1.5 million applicants. METU had the greatest share in national research funding by the Scientific and Technological Research Council of Turkey in the last five years, and it is the leading university in Turkey in terms of the number of European Union Framework Programme projects participation. Over 40% of METU's undergraduate alumni choose to pursue graduate studies. Wikipedia.
Sensoy I.,Middle East Technical University
Critical Reviews in Food Science and Nutrition | Year: 2014
This review highlights the effects of processing and food matrix on bioaccessibility and bioavailability of functional components. Human digestive system is reviewed as an element in bioavailability. Methods for bioaccessibility and bioavailability determination are described. Information about the location of functional compounds in the tissue is presented to portray the matrix information. Research data on the effects of food matrix and processing on bioaccessibility and bioavailability are summarized. Finally, trends in the development of functional component delivery systems are included. © 2014 Copyright Taylor and Francis Group, LLC.
Tekin B.,Middle East Technical University
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2015
We construct a massive spin-2 theory in 2+1 dimensions that is immune to the bulk-boundary unitarity conflict in anti-de Sitter space and hence amenable to holography. The theory is an extension of topologically massive gravity (TMG), just like the recently found minimal massive gravity (MMG), but it has two massive helicity modes instead of a single one. The theory admits all the solutions of TMG with a redefined topological parameter. We calculate the Shapiro time delay and show that flat-space (local) causality is not violated. We show that there is an interesting relation between the theory we present here (which we call MMG2), MMG, and the earlier new massive gravity (NMG): namely, field equations of these theories are nontrivially related. We study the bulk excitations and boundary charges of the conformal field theory that could be dual to gravity. We also find the chiral gravity limit for which one of the massive modes becomes massless. The virtue of the model is that one does not have to go to the chiral limit to achieve unitarity in the bulk and on the boundary, and the log-terms that appear in the chiral limit and cause instability do not exist in the generic theory. © 2015 American Physical Society.
Celik E.,Cornell University |
Calik P.,Middle East Technical University
Biotechnology Advances | Year: 2012
Yeasts are widely used in production of recombinant proteins of medical or industrial interest. For each individual product, the most suitable expression system has to be identified and optimized, both on the genetic and fermentative level, by taking into account the properties of the product, the organism and the expression cassette. There is a wide range of important yeast expression hosts including the species Saccharomyces cerevisiae, Pichia pastoris, Hansenula polymorpha, Kluyveromyces lactis, Schizosaccharomyces pombe, Yarrowia lipolytica and Arxula adeninivorans, with various characteristics such as being thermo-tolerant or halo-tolerant, rapidly reaching high cell densities or utilizing unusual carbon sources. Several strains were also engineered to have further advantages, such as humanized glycosylation pathways or lack of proteases. Additionally, with a large variety of vectors, promoters and selection markers to choose from, combined with the accumulated knowledge on industrial-scale fermentation techniques and the current advances in the post-genomic technology, it is possible to design more cost-effective expression systems in order to meet the increasing demand for recombinant proteins and glycoproteins. In this review, the present status of the main and most promising yeast expression systems is discussed. © 2011 Elsevier Inc.
Tekin B.,Middle East Technical University
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2014
We find the excitations and construct the conserved charges (mass and angular momentum) of the recently found minimal massive gravity (MMG) in 2+1 dimensions in asymptotically anti-de Sitter spacetimes. The field equation of the theory does not come from an action and lacks the required Bianchi identity needed to define conserved charges. But the theory, which also provides a healthy extension of the topologically massive gravity in the bulk and boundary of spacetime, does admit conserved charges for the metric that are solutions. Our construction is based on background Killing vectors and imperative to provide physical meaning to the integration constants in the black hole-type metrics. As an example, we compute the mass and angular momentum of the Bañados-Teitelboim-Zanelli black hole in MMG. We also find the central charges of the boundary field theory and study the chiral gravity limit of MMG. © 2014 American Physical Society.
Rojay B.,Middle East Technical University
Journal of Geodynamics | Year: 2013
The chaotic tectonic belt, which is distinguished in northern Anatolia, is called the - Ankara Accretionary Complex - in the Ankara region, central Anatolia. The belt is differentiated into three imbricated tectonic subbelts, namely, pre-Triassic metamorphics, Mélange with calcareous blocks and Cretaceous mélange with ophiolitic blocks (Ankara Ophiolitic Mélange).The Ankara Ophiolitic Mélange (AOM) is a chaotic tectono-sedimentary mixture made up of detached blocks of Mesozoic ultramafic rocks, Cretaceous pillow basalts, Cretaceous radiolarites, Upper Jurassic-Cretaceous limestones and closely associated Upper Cretaceous basinal sequences. The detached and dismembered blocks lie within a highly sheared and brecciated ophiolitic detrital matrix or a block-on-block to sheared sedimentary matrix that varies along the mélange belt. Cenomanian-Turonian and Turonian-Santonian trench-linked basin deposits onlap the Cenomanian sedimentary and Cretaceous ophiolitic mélanges. The elements of the ophiolitic mélange were comixed as a result of tectonic recycling in the accretionary wedge. The belt is unconformably overlain by Campanian-Maastrichtian to Paleogene accretionary fore-arc basin deposits.The AOM developed in an accretionary wedge setting in which oceanic leading edge of the Anatolide-Tauride platform subducted toward north during the post-Barremian-pre-Campanian period. The AOM emplaced episodically and progressively as a result of in thrust tectonics with vergence ranging from SSW to SE during the post-Turonian to pre-Miocene in the Ankara terrain. © 2012 Elsevier Ltd.