Asturias, Spain

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Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: FoF.NMP.2012-5 | Award Amount: 3.63M | Year: 2012

Todays fabrication methods for micro devices can require expensive tooling and long turnaround times, making empirical, performance-based modifications to the design expensive and time consuming. These methods also are limited in their flexibility, so that complex devices, that incorporate on-board valves, separation media, membranes, and recirculating pumps, cannot be developed and adapted without considerable expense in molds and assembly fixtures. This creates a barrier to the development of medium to large series of complex and higher functionality devices, where the cost-benefit ratio of incorporating functionality is too risky for the typical laboratory, diagnostic or medical device developer. To bridge the gap between a high volume production with specialized equipment and a - until today - not efficient production of medium series, SMEs need to find other, more flexible and scalable approaches to produce microsystems in high volumes. The solution proposed by SMARTLAM builds on a modular, flexible, scalable 3D-Integration scenario (3D-I), where novel polymer film materials will be combined with state of the art, scalable 3D printing, structuring and welding technologies. These technologies will be integrated in one production cell allowing for the production of complete 3D Microsystems. A 3D-Integration modeling environment will be set up to support users of the SMARTLAM environment by the design of 3D-I hardware compatible microsystems. Besides the technological challenges SMARTLAM will demonstrate a complete business case. A SME company acting as OEM service provider will be responsible for the real world benchmarking and testing of the SMARTLAM production platform concept. To assess and demonstrate the potential of SMARTLAM, two SME demonstrator partners will take over the role of potential customers, both providing input as well as assessing the 3-DI approach regarding costs, technological capabilities and adaptiveness.


Barnes E.O.,University of Oxford | Fernandez-La-Villa A.,MICRUX FLUIDIC | Pozo-Ayuso D.F.,MICRUX FLUIDIC | Castano-Alvarez M.,MICRUX FLUIDIC | And 4 more authors.
Journal of Electroanalytical Chemistry | Year: 2013

The oxidation of potassium ferrocyanide, K4Fe (CN)6, in aqueous solution under fully supported conditions is carried out at interdigitated band and ring electrode arrays, and compared to theoretical models developed to simulate the processes. Simulated data is found to fit well with experimental results using literature values of diffusion coefficients for Fe(CN)64- and Fe(CN)63-. The theoretical models are used to compare responses from interdigitated band and ring arrays, and the size of ring array required to approximate the response to a linear band array is investigated. An equation is developed for the radius of ring required for a pair of electrodes in a ring array to give a result with 5% of a pair of electrodes in a band array. This equation is found to be independent of the scan rate used over six orders of magnitude.© 2013 Elsevier B.V. All rights reserved.


Barnes E.O.,University of Oxford | Fernandez-La-Villa A.,MICRUX FLUIDIC | Pozo-Ayuso D.F.,MICRUX FLUIDIC | Castano-Alvarez M.,MICRUX FLUIDIC | Compton R.G.,University of Oxford
Journal of Electroanalytical Chemistry | Year: 2015

Electrochemical simulation is used to validate the geometry of commercially manufactured interdigitated array electrodes intended for use in generator-collector experiments, consisting of two interlocked arrays of band electrodes. A working surface is generated showing peak current as a function of scan rate and the inter electrode distance when cyclic voltammetry is performed at a single array of band electrodes. This working curve is then used to establish accurate electrode widths and inter-electrode distances of an interdigitated band array using a fully supported aqueous solution of ruthenium hexamine trichloride as a test system by running voltammetry at one of the two arrays at a time. Both arrays are then used at the same time to perform cyclic voltammetry to validate the established electrode geometries of 9.9 and 10.7 μm for the electrode widths in the two arrays, and 10.5 μm for the distance between adjacent electrodes. Cyclic voltammetry in generator-collector mode is then carried out, and these parameters used to successfully simulate the experimental data. The level of precision determined is essential for the quantitative interpretation of generator-collector measurements using interdigitated electrodes. © 2015 Elsevier B.V. All rights reserved.


Garcia-Gonzalez R.,University of Oviedo | Fernandez-La Villa A.,MICRUX FLUIDIC | Costa-Garcia A.,University of Oviedo | Fernandez-Abedul M.T.,University of Oviedo
Sensors and Actuators, B: Chemical | Year: 2013

Carbon nanotubes (CNTs) are nanostructures that have been discovered in 1991 but their interest continues growing due to their excellent properties and possible applications. In the field of Electroanalysis, most of those are based on the modification of working electrodes using solutions or dispersions in suitable solvents. However, the dispersing agent could have an important effect on the electrochemical behavior of analytes. In this work, an exhaustive study of dispersion of multi-walled carbon nanotubes (MWCNTs) functionalized with carboxylic (COOH), thiol (SH) and amine (NH2) groups in various solvents is performed. The electrochemical characterization of gold screen-printed electrodes (Au-SPEs) nanostructured with these dispersions of CNTs is carried out by recording the electrochemical signal from the redox reactions of a model analyte, methylene blue, by different electrochemical techniques (CV, SWV and DPV). Evaluation of the influence of the dispersing agent by itself is also made. © 2013 Elsevier B.V.


Fernandez-la-Villa A.,MICRUX FLUIDIC | Sanchez-Barragan D.,MICRUX FLUIDIC | Pozo-Ayuso D.F.,MICRUX FLUIDIC | Castano-Alvarez M.,MICRUX FLUIDIC
Electrophoresis | Year: 2012

A second generation of a battery-powered portable electrophoresis instrument for the use of ME with electrochemical detection was developed. As the first-generation, the main unit of the instrument (150 mm × 165 mm × 95 mm) consists of four-outputs high-voltage power supply (HVPS) with maximum voltage of 3 KV and acquisition system (bipotentiostat) containing 2-channels for dual electrochemical detection. A new reusable microfluidic platform was designed in order to incorporate the microchips with the portable instrument. In this case, the platform is integrated to the main unit of the instrument so that it is not necessary to have any external cable for the interconnection of both parts, making the use of the complete system easier. The new platform contains all the electrical connections for the HVPS and bipotentiostat, as well as fluidic ports for driving the solutions. The microfluidic electrophoresis instrument is controlled by means of a user-friendly interface from a computer. The possibility of wireless connection (Bluetooth®) allows the use of the instrument without any external cable improving the portability. Therefore, the second generation brings a more compact and integrated electrophoresis instrument for "in situ" applications using microfluidic chips in an easy way. The performance of the electrophoresis system was initially evaluated using single- and dual-channel SU-8/Pyrex microchips with different models of integrated electrodes including microelectrodes and interdigitated arrays. The method was tested in different analytical applications such as separation of neurotransmitters, chlorophenols, purine derivatives, vitamins, polyphenolic acids, and flavones. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Fernandez-La-Villa A.,MICRUX FLUIDIC | Bertrand-Serrador V.,MICRUX FLUIDIC | Pozo-Ayuso D.F.,MICRUX FLUIDIC | Castano-Alvarez M.,MICRUX FLUIDIC
Analytical Methods | Year: 2013

A novel ready-to-use portable microfluidic platform was adapted for analysis of uric acid and related compounds in urine samples. Microfluidic devices, especially microchips electrophoresis (ME), are very attractive for clinical and pharmaceutical analysis. Thus, a novel portable and easy-to-handle instrument, HVStat (165 × 150 × 85 mm), based on microfluidic electrophoresis chips with amperometric detection was used for the determination of uric acid and interfering compounds (ascorbic acid, paracetamol, epinephrine) in urine samples. Moreover, the microfluidic platform performance is controlled by a user-friendly PC interface (MicruX® Manager) especially designed for the use of microchips electrophoresis with electrochemical detection. The adapted analysis methodology at portable microfluidic platform allows the separation and detection of uric acid and related compounds in less than 90s with minimal sample pre-treatment. Thus, the uric acid is directly detected without previous enzymatic based-reactions or other complex pretreatment. The urine sample is simply diluted in the buffer solution and injected directly in the microchip where the uric acid is separated and detected at the platinum electrode of a SU-8/Pyrex microfluidic chip. The microfluidic chips were used for several analyses with a good performance and precision, decreasing drastically the cost and time per analysis. Thus, the complete microfluidic platform, including the main instrument, reusable holder and microchips, has been demonstrated as an excellent analytical tool for fast and reliable urine analysis. This journal is © 2013 The Royal Society of Chemistry.


Fernandez-la-Villa A.,MICRUX FLUIDIC | Pozo-Ayuso D.F.,MICRUX FLUIDIC | Castano-Alvarez M.,MICRUX FLUIDIC
Electrophoresis | Year: 2010

A new portable instrument that includes a high voltage power supply, a bipotentiostat, and a chip holder has been especially developed for using microchips electrophoresis with electrochemical detection. The main unit of the instrument has dimensions of 150 x 165 x 70mm (w x d x h) and consists of a four-outputs high voltage power supply with a maximum voltage of ±3 KV and an acquisition system with two channels for dual amperometric (DC or pulsed amperometric detection) detection. Electrochemical detection has been selected as signal transduction method because it is relatively easily implemented, since nonoptical elements are required. The system uses a lithium-ion polymer battery and it is controlled from a desktop or laptop PC with a graphical user interface based on LabVIEW connected by serial RS232 or Bluetooth®. The last part of the system consists of a reusable chip holder for housing the microchips, which contain all the electrical connections and reservoirs for making the work with microchips easy. The performance of the new instrument has been evaluated and compared with other commercially available apparatus using single- and dualchannel pyrex microchips for the separation of the neurotransmitters dopamine, epinephrine, and 3,4-dihydroxy-L-phenyl-alanine. The reduction of the size of the instrument has not affected the good performance of the separation and detection using microchips electrophoresis with electrochemical detection. Moreover, the new portable instrument paves the way for in situ analysis making the use of microchips electrophoresis easier. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.


PubMed | MICRUX FLUIDIC
Type: Evaluation Studies | Journal: Electrophoresis | Year: 2010

A new portable instrument that includes a high voltage power supply, a bipotentiostat, and a chip holder has been especially developed for using microchips electrophoresis with electrochemical detection. The main unit of the instrument has dimensions of 150 x 165 x 70 mm (wxdxh) and consists of a four-outputs high voltage power supply with a maximum voltage of +/-3 KV and an acquisition system with two channels for dual amperometric (DC or pulsed amperometric detection) detection. Electrochemical detection has been selected as signal transduction method because it is relatively easily implemented, since nonoptical elements are required. The system uses a lithium-ion polymer battery and it is controlled from a desktop or laptop PC with a graphical user interface based on LabVIEW connected by serial RS232 or Bluetooth. The last part of the system consists of a reusable chip holder for housing the microchips, which contain all the electrical connections and reservoirs for making the work with microchips easy. The performance of the new instrument has been evaluated and compared with other commercially available apparatus using single- and dual-channel pyrex microchips for the separation of the neurotransmitters dopamine, epinephrine, and 3,4-dihydroxy-L-phenyl-alanine. The reduction of the size of the instrument has not affected the good performance of the separation and detection using microchips electrophoresis with electrochemical detection. Moreover, the new portable instrument paves the way for in situ analysis making the use of microchips electrophoresis easier.


PubMed | MICRUX FLUIDIC
Type: Journal Article | Journal: Electrophoresis | Year: 2012

A second generation of a battery-powered portable electrophoresis instrument for the use of ME with electrochemical detection was developed. As the first-generation, the main unit of the instrument (150 mm 165 mm 95 mm) consists of four-outputs high-voltage power supply (HVPS) with maximum voltage of 3 KV and acquisition system (bipotentiostat) containing 2-channels for dual electrochemical detection. A new reusable microfluidic platform was designed in order to incorporate the microchips with the portable instrument. In this case, the platform is integrated to the main unit of the instrument so that it is not necessary to have any external cable for the interconnection of both parts, making the use of the complete system easier. The new platform contains all the electrical connections for the HVPS and bipotentiostat, as well as fluidic ports for driving the solutions. The microfluidic electrophoresis instrument is controlled by means of a user-friendly interface from a computer. The possibility of wireless connection (Bluetooth) allows the use of the instrument without any external cable improving the portability. Therefore, the second generation brings a more compact and integrated electrophoresis instrument for in situ applications using microfluidic chips in an easy way. The performance of the electrophoresis system was initially evaluated using single- and dual-channel SU-8/Pyrex microchips with different models of integrated electrodes including microelectrodes and interdigitated arrays. The method was tested in different analytical applications such as separation of neurotransmitters, chlorophenols, purine derivatives, vitamins, polyphenolic acids, and flavones.


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