McKinney, TX, United States
McKinney, TX, United States

Time filter

Source Type

Foster B.,Microscopy and Imaging Place Inc. | Foster B.,American Laboratory Labcompare
American Laboratory | Year: 2012

The BioScope Catalyst opens new vistas for life science research. Its ScanAsyst and Peak Force QNM modes offer a gentler, more controlled, and directly quantitative solution especially well-suited for molecular biology, biophysics, and true nanomechanical studies. The powerful MIRO software precisely overlays nanoscale AFM imaging and measurements with light, confocal, and the various fluorescence modalities, providing new insights into cell dynamics and nano-mechanics. This new approach produces high-resolution images at all size domains, from single molecules to biomolecular aggregates such as membranes, then on to cells and tissue. ScanAsyst and Peak Force QNM promise to be exciting new tools for a wide range of applications, from the pathology of cancer, infectious diseases, and neurodegenerative disorders to proactive, commercialized technology in tissue engineering, biomemetics, and biosensors.


Foster B.,Microscopy and Imaging Place Inc. | Dugaiczyk I.,Ushio America Inc | Cordero K.,Ushio America Inc
Biophotonics International | Year: 2010

Fluorescence microscopy presents an array of illumination challenges, key being the matching of the spectrum of the light source to the fluorophore in the sample, to the bulb alignment and lifetime, and to the evenness of illumination. The gold standard for light sources for fluorescence microscopy today is the 100-W mercury arc lamp. The process is repeated for the mirror image of the source, using the focus and centration controls for the rear reflector. Depending upon the microscope manufacturer, the direct image and the mirror image are either aligned side by side or superimposed. A second solution involves using a remote illuminator-coupled microscope via a fiber lightguide. For decades, the 100-W mercury arc has been the gold standard for illumination for fluorescence microscopy in cell and tissue applications as well as for genomics and proteomics.


Foster B.,Microscopy and Imaging Place Inc.
American Laboratory | Year: 2015

The new family of mobile microRaman microscopes offers "Raman microscopy on-the-go." Their portable design enhances speed and sensitivity while economizing on laser power. Incorporating multiple sample modalities, they are an easy-to-use, cost-effective alternative to multiple instruments normally required for these analyses. Moving from the lab to the pilot plant, from the clinic to the classroom, or from the local lake to the crime scene, they promise to significantly expand Raman's analytical capabilities.


Foster B.,Microscopy and Imaging Place Inc.
American Laboratory | Year: 2012

From research stand to student "shoe box," the microscopy/spectroscopy chasm is definitely shrinking as micro Raman becomes part of the analytical mainstream in both the materials and life sciences Optical micro Raman has become a mainstay and is now an important correlative technique to AFM-Raman, giving "eyes to chemistry" from the nano scale to the micro scale.


Foster B.,Microscopy and Imaging Place Inc.
American Laboratory | Year: 2011

X-Cite® XLED1 from Lumen Dynamics Group (LDGI), Mississauga, Canada, is an instrument that can surpass existing LED performance in the study of biological fluorescence performance. The product can be used for regular florescence microscopy as well as conventional and spinning disk confocal, multiphoton, structured illumination, and super-resolution systems. To avoid user error, the LED uses intelligent software and feedback to recognize immediately which module is in which location. In addition to receiving signals, the X-Cite XLED's sync-out can send signals to other peripherals such as a camera or microscope stage. The light is more controlled and more consistent and the LED system produce flat, evenly illuminated fields, without flicker and with excellent signal-to-noise ratios that allow the biology to shine through against a rich black background.


Foster B.,Microscopy and Imaging Place Inc.
Biophotonics International | Year: 2011

A significant increase in quantitative fluorescence and live-cell work is driving a need for microscopists to understand, control, and calibrate their instrumentation. NIC researchers and students have tried to answer these questions using standard handheld laser power meters. A potential new source of inconsistency has entered the optical train, as fluorescence illumination has evolved from tungsten filament to arc sources to metal halide systems. This potential new source of inconsistency involves failure in the liquid lightguide (LLG) that connects the lamp to the stand. LLG connecting the lamp to the stand adds a new dimension to more traditional problems, such as delamination shields, or burned areas in filters or heat shields, and foreign objects stuck at unwanted places. Work at The BioImaging Group in the Life Sciences Division Lawrence Berkeley National Laboratory (LBNL) focuses on correlative microscopies to address these challenges.


Foster B.,Microscopy and Imaging Place Inc.
Biophotonics International | Year: 2011

The article offers a quick update on the four key technologies leading the SR revolution and insights from interviews with major providers presenting those technologies at Neuroscience. Various forms of electron and scanning probe microscopy have been investigating this domain for decades. By manipulating illumination, structured illumination microscopy (SIM) and stimulated emission depletion (STED) drop the conventional X-Y resolution to the 65- to 90-nm range. Superresolution is opening new vistas onto cellular nanostructures such as micro-tubules or mitochondrial cristea, which have to date been just beyond our ability to image with optical microscopy. Instead of using normal wide-field excitation, SIM projects the excitation onto the sample in a structured pattern, typically a grid of lines of known spacing.


Foster B.,Microscopy and Imaging Place Inc.
American Laboratory | Year: 2010

A number of companies from the US are developing and introducing new solutions for surface texture analysis. Keyence's VK-9700 and Olympus Industrial's LEXT 4000 use a white light source for true-color confocal imaging and a violet light-emitting diode (LED) as a secondary light source to enhance resolution. Carl Zeiss, Thornwood, NY, offers two versions of confocal: the more industrial ASM 700, which is a white light system and the more traditional laser-based LSM 700. The LSM 700 offers a combination of fluorescence and reflected light mode, making it an interesting solution in situations in which fluorescence can be applied to image and measure defects, contamination, or special particles of interest, while the ASM 700 operates in reflected light mode used in most industrial applications. Leica is another company that is offering a customized version of Sensofar's dual core system as the DCM 3D Measuring microscope, combining interferometry and confocal on a single stand.

Loading Microscopy and Imaging Place Inc. collaborators
Loading Microscopy and Imaging Place Inc. collaborators