Woking, United Kingdom
Woking, United Kingdom

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Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: SEC-2012.7.2-1 | Award Amount: 2.00M | Year: 2013

Forensic analysis is an essential resource in the battle against organised crime and terrorist attacks. A key challenge in forensics is the detection of trace explosive residues at a post-blast scene or on the hands or clothes of an alleged suspect. Detection of the primer charge (e.g., PETN) is often hampered by higher-concentration residues from the main charge, e.g., ammonium nitrate. Detection of the primer can be essential in order to secure a prosecution, especially if the materials that comprise the main charge are commonly available, e.g., ammonium nitrate is present in fertiliser. ROSFENs goal is to deliver an advanced forensic platform for rapid, on-site direct detection and lab-quality analysis of narcotics, explosives and their precursors. The performance targets are detection limits down to 1 ng/mL, 1% false alarm rate and response time < 10 seconds. ROSFEN combines innovative technology from two leading SMEs: Microsaic Systems chip-based mass spectrometry and Environics ion filter systems. This novel platform removes the need for slow, costly chromatography methods currently used in lab-based analysis. ROSFEN will enable reduction of total analysis time (samples, blanks, controls) from hours to minutes, thus reducing the load on forensic labs and enabling intelligence-led investigations. ROSFEN will also innovate in the rapid analysis of new psychoactive drugs, by coupling the isomer selectivity of the ion filter technique with the detection sensitivity of tandem MS. ROSFEN will thus enable European industry to develop and deliver innovative technologies into key global markets: Analytical instruments for security applications ($2 billion annually) and the $3.3B market for mass spectrometry. The ROSFEN consortium comprises two research-intensive SMEs, two leading research groups and two end users. The end users have decades of expertise in forensic analysis of explosives and narcotics (FSNI), as well as crime scene analysis (PSNI).


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2009.3.9 | Award Amount: 4.34M | Year: 2010

The goal of ARROWS is to develop a microengineered platform for the analysis of real-world samples from the food, drink and healthcare industries. The principle deliverable will be a chip-scale capillary electrophoresis/liquid chromatography mass spectrometer (CE/LC-MS) that matches the performance of todays mainframe systems.\n\nThe ARROWS innovation is to integrate and interface multiple chip technologies into a platform capable of analysing messy, sticky biological matrices like tissue, food, blood and urine. Our vision is to offer users from the food, environmental and clinical sectors more for less by delivering the functionality of a laboratory-scale, high-end CE/LC-MS system, which today is the size of a filing cabinet, in a mass-deployable tool the size of a desktop PC.\n\nNext-generation micro-analytical devices from Tyndall, Microsaic, VTT and CSEM will be combined into powerful, multi-sensing tools capable of identifying trace quantities of the chemical species of interest (e.g. pesticides, disease biomarkers) in complex biological matrices such as tissue, food and drinking water. Microsaic Systems will develop a MS based on patented ionchip technology.\n\nCE/LC/MS is a universal technique and analytical applications are unlimited. Initially, ARROWS will focus on two applications: (a) detection of cancer biomarkers in fractional spots found on tissue, and (b) screening of imported food for contamination. End-users Charit Universittsmedizin Berlin and DEFRA will evaluate the platform.\n\nARROWS utilizes the consortiums best-in-class capabilities to exploit the scaling laws associated with microfluidics, chip-based chromatography and electrophoresis and microengineered advanced mass spectrometry to minimise analysis time, sample volume and reduce manufacturing costs. These scaling laws address the cross-cutting issue of sustainability by reducing solvent consumption, waste and power consumption by orders of magnitude.


Patent
Microsaic | Date: 2010-10-12

A portable analytical system for the rapid on-site analysis of fluids, and a method for using this system at the well-site for the analysis of samples extracted from drilling fluids is described. The portable analytical solution may be deployed at the well-site and used to perform detailed real-time analysis of formation fluids and extracts of rock cuttings. The method described could be used during hydrocarbon exploration and production to determine whether the drill stem has passed through a hydrocarbon-bearing region, or rocks that are capable of functioning as an oil reservoir or that may have been a source rock, or that may have come into contact with oil, or that may contain oil at present.


Patent
Microsaic | Date: 2011-01-10

This invention provides a method of aligning sets of cylindrical electrodes in the geometry of a miniature quadrupole electrostatic lens, which can act as a mass filter in a quadrupole mass spectrometer. The electrodes are mounted in pairs on microfabricated supports, which are formed from conducting parts on an insulating substrate. Complete segmentation of the conducting parts provides low capacitative coupling between co-planar cylindrical electrodes, and allows incorporation of a Brubaker prefilter to improve sensitivity at a given mass resolution. A complete quadrupole is constructed from two such supports, which are spaced apart by further conducting spacers. The spacers are continued around the electrodes to provide a conducting screen.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: KBBE-2008-3-2-03 | Award Amount: 3.95M | Year: 2009

There is a growing need for effective monitoring of the micro-organisms and bioprocesses used in the sustainable production of fuels, chemicals and pharmaceuticals. The NANOBE -consortium will develop a compact, flexible analysis tool for reaction monitoring applications in the industrial biotechnology industry. The result of the NANOBE project will be an integrated measurement platform for real-time monitoring of industrial bioprocesses. This versatile platform will enable simultaneous analysis of dozens of analytes, including individual cells, product profiles and intracellular biomarkers. The platform will be composed of multiple lab-on-chip modules. Together, these modules will measure a broad range of analyte types, including small molecules, proteins, enzymes, metabolites, specific mRNAs and entire cells. The measurement platform will be a significant improvement in terms of automation, analysis time, identification and sensitivity. The analysis platform will permit real-time feedback control of large-scale production processes, screening of production organisms and optimisation of reaction conditions. The tool will improve process productivity, product quality and accelerate development of production organisms for applications in industrial biotechnology. The platform is designed to be flexible so that it can be applied either as a multiplex platform system to monitoring multiple analytes, or as individual device components for analysis of specific compounds. The versatile measurement tool will require only a change in method (e.g. a change of reagents or analysis conditions) to enable the measurement of a new analyte. The NANOBE consortium combines world-class expertise in microfluidics, nano- and microfabrication techniques, photonics, electronics, sensor technologies, and biotechnology. The platform will exploit the scaling laws associated with microfluidic devices to reduce analysis time and sample volume.


Patent
Microsaic | Date: 2010-11-30

A sample collection and detection system is described. The detection system provides a sample chamber fluidly coupled to a secondary ionisation source to allow the introduction of vapour generated from the sample into an ion path generated from the secondary ionisation source. The secondary ionisation source is a secondary electrospray ionisation (SESI) source, and is usefully employed in dust analysis.


Patent
Microsaic | Date: 2010-11-19

This invention describes an analytical system where a kinetic impact ionisation source is combined with an RFonly ion guide to form a mass spectrometer system for analysis of the elemental and chemical composition of exoatmospheric particles. The kinetic impact ionisation source may be used to transform a flux of particle debris into a beam of ions for analysis by a mass analyzer.


A device and method is described for direct analysis of solvents used to chemically bind with CO_(2 )present in flue gases, and for the monitoring of large-scale CO_(2 )solvent-capture reaction to improve process efficiency, thereby reducing the cost of CO_(2 )capture.


Patent
Microsaic | Date: 2011-03-22

A method of mounting rods in quadrupole, hexapole, octupole, and other multipole geometries is described. First and second dies are used to hold the rods in the required configuration with the plurality of rods extending through each of the two dies. A coupling arrangement is used to separate the first and second dies, and also prevents motion in the plane of the dies. The rods are seated and retained against individual supports and arranged circumferentially about an intended ion beam axis. The supports are desirably fabricated from silicon bonded to a glass substrate, a support for a first rod being electrically isolated from a support for a second adjacent rod.


Patent
Microsaic | Date: 2011-03-22

A microengineered multipole ion guide for use in miniature mass spectrometer systems is described. Exemplary methods of mounting rods in hexapole, octupole, and other multipole geometries are described. The rods forming the ion guide are supported in etched silicon structures defined in at least first and second substrates.

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