Microphyt

Baillargues, France

Microphyt

Baillargues, France

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Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2016 | Award Amount: 1.60M | Year: 2017

The GHaNA project aims to explore and characterize a new marine bioresource, for blue biotechnology applications in aquaculture, cosmetics and possibly food and health industry. The project will determine the biological and chemical diversity of Haslea diatoms to develop mass-scale production for viable industrial applications by maximising biomass production and associated high-value compound production, including terpenoids, marennine-like pigments, lipids and silica skeletons. The genus Haslea species type H. ostrearia, produces marennine, a water-soluble blue pigment used for greening oysters in Western France, which is also a bioactive molecule. Haslea diatoms have thus a high potential for use in (1) existing oyster farming, (2) production of pigments and bioactive compounds with natural antibacterial properties, (3) application as a colouring agent within industry, and (4) use of silica skeletons as inorganic biocharges in the formulation of new elastomeric materials. This will be achieved through fundamental and applied-oriented research to isolate fast- growing strains of Haslea, optimising their growth environment to increase marennine and other high-value compound productivity; to develop blue biotechnology specifically applied to benthic microalgae (biorefinery approach, processes); and to develop industrial exploitation of colouring and bioactive compounds through commercial activities of aquaculture, food, cosmetics and health.


Valiorgue P.,École Centrale Lyon | Ben Hadid H.,École Centrale Lyon | El Hajem M.,École Centrale Lyon | Rimbaud L.,Microphyt | And 2 more authors.
Chemical Engineering Research and Design | Year: 2014

This study deals with CO2 mass transfers and biomass conversion in an industrial horizontal tubular photobioreactor. An analytical approach is used to determine an expression modeling the influence of CO2 mass transfers on the overall biomass conversion efficiency for a given culture broth, heat and light conditions. Fluid mechanics and mass transfer are predicted with a classical two-phase flow approach (Taitel and Dukler, 1976) combined with a dissolution correlation developed and tested in the laboratory (Valiorgue et al., 2011). The influence of the stripping gas, removing the excess of oxygen in the liquid, on the conversion to biomass efficiency is shown to be not negligible. The expression is used to evaluate how the photobioreactor's design and process parameters can be tuned in order to improve biomass conversion efficiency. The biomass conversion efficiency evolution with the photobioreactor's length was found to behave asymptotically and it was explained by the relative orders of magnitude of gas dissolution and gas stripping. It has been shown that the gas flow rate for stripping and therefore the oxygen removal will be limited when further increasing the industrial photobioreactor's length for a given objective of CO2 conversion to biomass efficiency. © 2014 The Institution of Chemical Engineers.


Muller-Feuga A.,Microphyt | Lemar M.,Microphyt | Vermel E.,Microphyt | Pradelles R.,Microphyt | And 2 more authors.
Journal of Applied Phycology | Year: 2012

A closed tubular horizontal photobioreactor with the ability to produce industrially delicate microalgal species was assessed and validated. A co-current gas-liquid flow was chosen for mass transfer along 1,200 m piping which delimited a culture volume of 4,700 L. Mixing was obtained by means of hydrodynamic events accompanying this type of flow, including waves. The constant cross section of the piping allowed the circulation of spherical bodies to wipe the inner wall and avoid the establishment of a biofilm. Two similar reactors were constructed in December 2009 and December 2010, and operated to supply the dermo-beauty care industry with active biomass of three delicate species of microalgae, including the chlorophyte Neochloris oleoabundans and the rhodophyte Porphyridium cruentum. Daily observed production of dry biomass varied between 0. 2 and 1. 7 kg, depending on the species, the sun exposure and the period of the year. The ability of this production system to reduce the cost of producing algal biomass through scaling-up is discussed. © 2012 Springer Science+Business Media B.V.


Grant
Agency: European Commission | Branch: H2020 | Program: SME-2 | Phase: SMEInst-08-2016-2017 | Award Amount: 2.56M | Year: 2016

Building up on a successful Phase 1, the French SME MICROPHYT has demonstrated its ability to industrially over-produce specific marine bioactive compounds from selected microalgae. Through innovative and patented processes, it delivers unequalled concentration of these compounds which have already shown preliminary positive effects in the nutrition & health domains. Leveraging the company initial knowledge and expertise, the SMILE program aim at delivering a ready-for-market and highly effective microalgae-based ingredient for food supplement and nutraceutical applications. This ingredient will target weight management and preservation of cognitive function, two current major societal challenges, through a differentiated and sustainable approach. The successful commercial launch of SMILE Ingredient will depend on its ability to create added-value to the industry customers and to demonstrate full safety and efficacy for the end-user. As outcomes of Phase 2, MICROPHYT will deliver demonstrated and reliable information on the future ingredient and will have secured regulatory compliance in order to market SMILE ingredient in the EU and the USA. SMILE project is of strategic importance for MICROPHYT since it allows the company to extend its expertise from microalgae culture to downstream processes, and thus to market a higher added-value product, addressing consumers needs for natural and safe ingredients. As the new MICROPHYTs star product, SMILE is essential to foster companys competiveness and to strengthen its position on attractive and profitable market segments. At mid-term, this disruptive innovation has the potential to change the dynamics of food supplement market. With at least two new patents filed, SMILE will represent more than 85% of MICROPHYTs sales and create 30 jobs by 2022, accelerating and sustaining the companys growth internationally.


A reaction casing for a photosynthetic reactor designed firstly to float on a body of water and secondly to delimit a biphasic flow pathway for gas/liquid culture medium between a first and a second opening of the casing, where the casing includes two claddings, respectively outer and inner, made at least in part of a material transparent to light rays, the inner cladding extending inside the outer cladding so that the claddings delimit between them an inter-cladding space in fluid connection with the first opening of the casing, the outer cladding has an open proximal end and a closed distal end and in the inner cladding has an open proximal end in fluid connection with the second opening of the casing and a distal end provided with at least one communication orifice between the inside of the inner cladding and the inter-cladding space.


Patent
Microphyt | Date: 2015-04-20

Methods for cultivating photosynthetic microorganisms are described. The method includes the steps of injecting a liquid culture medium into a photosynthetic reactor according to a controlled flow rate, injecting a gas into the reactor according to a controlled flow rate through a gas injector of the reactor so that the gas injected through the gas injector moves up to as far as the exhaust by circulating in the reaction pipe, in a direction of circulation from the low end to as far as the high end of the reaction pipe, circulating the liquid culture medium with the circulation device, and controlling the circulation device and the gas injector in order to establish in at least one substantially horizontal reaction section of the reaction pipe gas/liquid two-phase flow conditions of the laminated flow or slug flow or elongated bubble flow type.


Reaction casing (1) for a photosynthetic reactor suitable for cultivating photosynthetic microorganisms, in particular algae, said reaction casing (1) being designed for both floating on an expanse of water and defining a path for a gas/liquid culture medium to flow in two phases between a first and a second opening (11, 12) of said casing. The casing comprises, on the one hand, an upper membrane (31) and a lower membrane (32) made at least partially of a flexible material, hermetically sealed and transparent to light radiation, said membranes being hermetically connected to one another by connecting lines (41, 42) defining inflatable cells (33, 34) and, on the other hand, connection elbows (35, 36) joining said cells in pairs to define the course of flow in a generally sinuous form, one of the cells (33) being fluidly linked to the first opening and another cell (34) being fluidly linked to the second opening (12). The present invention is applicable in the field of photosynthetic microorganism cultivation, in particular algae cultivation.


A photosynthetic reactor (1) suitable for cultivating photosynthetic microorganisms, notably algae, comprising at least one photosynthetic reaction pipe (2) at least one return pipe (3), at least one means (4) for circulating the liquid culture medium, at least one gas injection means (5) and at least one exhaust means (6) positioned in the high portion of the reactor (1), wherein the placement of the gas injection means (5) and/or the conformation of the reaction pipe (2) or of the return pipe (3) are designed so that the gas injected by the injection means (5) rises again to the exhaust means (6) by circulating in the reaction pipe (2), in a low-to-high flow direction, so that the injected gas and the liquid culture medium establish a gas/liquid two-phase flow in a substantially horizontal reaction section (23) of the reaction channel (2). The present invention finds application in the field of cultivating photosynthetic microorganisms and notably algae.


Reaction jacket for a photosynthetic reactor, configured to float on an expanse of water and to define a gas/liquid culture medium diphasic flow path between first and second openings of the reaction jacket, the jacket including two sheaths, outer and inner, respectively, at least partially made from a material transparent to light radiation, the inner sheath extending inside the outer sheath such that these sheaths define an inter-sheath space between them in fluid connection with the first opening of the jacket, where the outer sheath has an open proximal end and a closed distal end, and the inner sheath has an open proximal end in fluid connection with the second opening of the jacket and a distal end provided with at least one communication orifice between the inside of the inner sheath and the inter-sheath space.


Grant
Agency: European Commission | Branch: H2020 | Program: SME-1 | Phase: BG-12-2014-1 | Award Amount: 71.43K | Year: 2015

The SMILE project aims at developing a microalgae-based innovative natural marine ingredient with scientifically demonstrated benefits on weight management and metabolism issues. Obesity and overweight concerning 37% of world population in 2013 (The Lancet, 2014) represent major global health challenges causing millions of deaths worldwide. Well integrated comprehensive strategies can contribute to overweight management. Specifically developed bioactive compounds used in food supplements can help people wanting to lose weight. Consumer are looking for safe, effective (scientifically proven), affordable and natural solutions on these issues that represent today an unmet need. Marine environment is full of biological compounds that could represent relevant answers to these needs. Especially, a specific marine carotenoid found in algae, has received a strong and recent interest from the industry as several scientific publications have demonstrated superior efficacy of this molecule in comparison of existing products targeting weight reduction. However, the only available sourcing (a macroalgae) presents several drawbacks such as the presence of micro-pollutants and some sustainability issues. Through an innovative and patented technology, Microphyt produces sustainably and markets unique bioactive compounds extracted from the untapped diversity of microalgae. Microphyt has identified few strains which are difficult to produce in competitors systems and that are able to produce high quantities of this specific marine carotenoid. Moreover, our specific process allow the optimal production of this compound combined with PUFAs which exhibit demonstrated synergistic effects on metabolism. In this context SMILE ingredient represents a high added value potential for Microphyt. Phase 1 feasibility study aims at further analyzing IPR and regulatory status of the different strains, releasing a detailed business plan based on market feedback and pursue the scale up of the best selected strain.

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