Microfluidics, Janssen Pharmaceutical and NXP Semiconductors | Date: 2016-08-10
The invention relates to a channel for trapping particles to be fed to the channel with a fluid. The invention further relates to a flow cell comprising such a channel. The invention also relates to an assembly comprising such a flow cell and a detection means. The invention also relates to a method for trapping particles in such a channel. And finally, the invention relates to a method for analyzing a sample using such an assembly.
Microfluidics, Janssen Pharmaceutical and NXP Semiconductors | Date: 2017-02-15
The invention relates to a channel for trapping particles to be fed to said channel with a fluid, said channel having a bottom and opposite sidewalls, the sidewalls defining a width of the channel, said channel further comprising:- a first channel part;- a second channel part in fluid through flow connection with said first channel part and downstream of said first channel part;- an elevated structure provided in said channel that divides said channel in said first channel part and said second channel part and for trapping particles in said first channel part;- at least one flow gap provided by said elevated structure for providing said fluid through flow connection between the first channel part and the second channel part for allowing, in use, at least some fluid to flow past said elevated structure into said second channel part while trapping said particles in said first channel part;wherein said elevated structure is substantially U-shaped and has a base extending substantially between the opposite sidewalls of the channel and two legs extending from the base in an upstream direction, wherein at least part of said U-shaped elevated structure defines at least part of a particle trapping area for trapping the particles to be fed to said channel. The invention further relates to a flow cell comprising such a channel. The invention also relates to an assembly comprising such a flow cell and a detection means. The invention also relates to a method for trapping particles in such a channel. And finally, the invention relates to a method for analyzing a sample using such an assembly.
Microfluidics | Date: 2017-04-05
Apparatuses and methods that reduce cavitation in interaction chambers are described herein. In an embodiment, for a fluid processor or fluid homogenizer, preferably a high shear processor or a high pressure homogenizer, includes an inlet chamber, preferably an inlet cylinder, and an outlet cylinder, wherein an entrance to the microchannel from the inlet chamber is offset a distance from the bottom end of the inlet chamber, and at least one of: (i) at least one tapered fillet located on at least one side wall of the microchannel at the microchannel entrance; (ii) at least one side wall of the microchannel converging inwardly from the inlet chamber to the outlet chamber; (iii) at least one of a top wall and a bottom wall of the microchannel angled from the inlet chamber to the outlet chamber; and (iv) a top fillet that extends around a diameter of inlet chamber.
Agency: European Commission | Branch: H2020 | Program: ECSEL-IA | Phase: ECSEL-02-2014 | Award Amount: 48.05M | Year: 2015
The goal of the InForMed project is to establish an integrated pilot line for medical devices. The pilot line includes micro-fabrication, assembly and even the fabrication of smart catheters. The heart of this chain is the micro-fabrication and assembly facility of Philips Innovation Services, which will be qualified for small/medium-scale production of medical devices. The pilot facility will be open to other users for pilot production and product validation. It is the aim of the pilot line: to safeguard and consolidate Europes strong position in traditional medical diagnostic equipment, to enable emerging markets - especially in smart minimally invasive instruments and point-of-care diagnostic equipment - and to stimulate the development of entirely new markets, by providing an industrial micro-fabrication and assembly facility where new materials can be processed and assembled. The pilot line will be integrated in a complete innovation value chain from technology concept to high-volume production and system qualification. Protocols will be developed to ensure an efficient technology transfer between the different links in the value chain. Six challenging demonstrators products will be realized that address societal challenges in: Hospital and Heuristic Care and Home care and well-being, and demonstrate the trend towards Smart Health solutions.
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: PHC-30-2015 | Award Amount: 5.01M | Year: 2016
SMARTool aims at developing a platform based on cloud technology, for the management of patients with coronary artery disease (CAD) by standardizing and integrating heterogeneous health data, including those from key enabling technologies. The platform includes existing multiscale and multilevel ARTreat (FP7-224297) models of coronary plaque progression based on non-invasive coronary CT angiography (CCTA) and fractional flow reserve computation, refined by heterogeneous patient-specific non-imaging data (history, lifestyle, exposome, biohumoral data, genotyping) and cellular/molecular markers derivable from a microfluidic device for on-chip blood analysis. SMARTool models will be applied and validated by historical and newly acquired CCTA imaging plus non-imaging health data from the EVINCI project (FP7-222915) population. SMARTool cloud-based platform, through Human Computer Interaction techniques, 3D visual representation and artery models, will use heterogeneous data in a standardized format as input, providing as output a CDSS - assisted by a microfluidic device as a point of care testing of inflammatory markers for: i) Patient specific CAD stratification - existing models, based on clinical risk factors, will be implemented by patient genotyping and phenotyping to stratify patients with non-obstructive CAD, obstructive CAD and those without CAD, ii) site specific plaque progression prediction - existing multiscale and multilevel ARTreat tools of CAD progression prediction will be refined by genotyping and phenotyping parameters and tested by baseline and follow CCTA and integrated by non-imaging patient-specific data, iii) patient-specific CAD diagnosis and treatment - life style changes, standard or high intensity medical therapy and a virtual angioplasty tool to provide the optimal stent type(s) and site(s) for appropriate deployment.
Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.98M | Year: 2013
The objective is to deliver a trans-European network of industrially oriented specialists fully trained in the development and application of microbioreactor (MBR) technology to support development of innovative bio-based manufacturing processes. The specialistis will be trained by leaders in the field and with state of the art equipment and methodologies. MBRs are a promising tool for screening and scale-up of fermentation and biocatalysis processes due to their low production cost, small working volumes, flexibility and their potential for information-rich experiments under well-controlled experimental conditions. In this consortium, we will further develop MBRs for chemical and biochemical screening, paying special attention to MBR parallelization and applicability for different applications. In addition, characterization of experimental uncertainty, development of reactant feeding strategies at micro-scale and coupling of microscale experimentation to automated design of experiments (DoE) will document applicability of MBRs for chemical and biochemical research. To enhance the applicability of microfluidic enzymatic reactors for organic synthesis, we will establish microfluidic chemo-biocatalytic reaction systems that enable rapid characterization of biosynthetic pathways and chemo-enzymatic conversions. This will be underpinned with immobilization methods that permit rapid and reversible binding of a range of biocatalysts and modeling that relates the kinetic data with results from larger scales. Complemented with precisely positioned fluorescence-based sensor arrays, novel nanosensor particle concepts, and integrated Raman and NIR probes, the MBRs will deliver the data-rich experimentation needed for industrial applications. Data processing and information management will be accomplished by developing CFD and mathematical modeling methods that permit prediction and interpretation of fermentation and biocatalytic processes in MBRs.
Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 4.23M | Year: 2013
LAPASO will provide a unique training opportunity for 15 fellows in a highly interdisciplinary and intersectorial environment with the overarching scientific objective of advancing diagnostics in a wide range of critical medical conditions using advanced microfluidics and nanobiotechnology integration. Microfluidic particle fractionation based on the inherent properties of e.g. cells, microorganisms, organelles offers significant improvements over conventional techniques in terms of ease of handling and usage, speed and reductions in cost. We will consolidate the field at the European level and create a unique comprehensive training program that rests on solid experimental and theoretical foundations. Three leading experimental groups will provide the technological development of microfluidic label-free sorting based on dielectrophoresis, deterministic lateral displacement and acoustophoresis with strong support from leading theorists. The technology will be used to address key medical questions defined by our biomedical collaborators and partners in parasitology, bacteriology and oncology. Three companies are engaged to provide an industrial perspective on our work, specifically from a technological point of view with respect to treatment of infectious disease, advanced fluidics handling and DNA analysis and mass production of devices. To ensure an efficient transfer of knowledge across disciplines and across sectors the work will take place in close collaboration through frequent ESR/ER exchange between the partners. The training of a next generation of researchers will ensure the implementation and dissemination of these powerful novel key techniques to industry and end-users. Through the strong interdisciplinary and intersectorial character of the network, the ESR and ER will receive a uniquely comprehensive training above what a traditional postgraduate training would offer that in turn gives them a strong competitive advantage in both academia and industry.
Microfluidics | Date: 2015-05-29
Apparatuses and methods that reduce cavitation in interaction chambers are described herein. In an embodiment, an interaction chamber for a fluid processor or fluid homogenizer includes an inlet chamber having an inlet hole and a bottom end, an outlet chamber having an outlet hole and a top end, a microchannel placing the inlet hole in fluid communication with the outlet hole, wherein an entrance to the microchannel from the inlet chamber is offset a distance from the bottom end, and at least one of: (i) a tapered fillet located on a side wall of the microchannel at the microchannel entrance; (ii) a side wall of the microchannel converging inwardly from the inlet chamber to the outlet chamber; (iii) a top wall and/or bottom wall of the microchannel angled from the inlet chamber to the outlet chamber; and (iv) a top fillet that extends around a diameter of inlet chamber.
Microfluidics | Date: 2015-07-10
A mixing assembly includes an inlet, an outlet and a mixing chamber, the inlet is fluidly connected to the outlet through a plurality of micro fluid flow paths in a direction perpendicular from the inlet. The micro fluid flow paths fluidly connect to the perpendicular inlet via a transition portion. The micro fluid flow paths are constructed radially inwardly to a concentration area in the mixing chamber. By directing multiple fluid flows to a concentrated area within the mixing chamber at high speeds, the energy dissipated at the point of collision is maximized, which helps to increase consistency and quality of mixing, and to reduce particle size of the fluid in the mixing chamber.
Microfluidics | Date: 2015-07-15
A mixing assembly includes an inlet, an outlet and a mixing chamber, the inlet is fluidly connected to the outlet through a plurality of micro fluid flow paths in a direction perpendicular from the inlet. The micro fluid flow paths fluidly connect to the perpendicular inlet via a curved transition portion. The curved transition portion provides a more efficient flow path for the fluid to travel from the inlet to the micro fluid flow paths to the mixing chamber. By transitioning the direction change, flow resistance is decreased, and the fluid flow rate and shear rate is increased. Increased fluid flow rate and shear rate helps to increase consistency and quality of mixing, and to reduce particle size of the fluid in the mixing chamber.