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Lafaurie M.,Infectious Diseases Intervention Unit U2i | Porcher R.,University Paris Diderot | Donay J.-L.,Microbiology | Touratier S.,Pharmacy | Molina J.-M.,University Paris Diderot
Journal of Antimicrobial Chemotherapy | Year: 2012

Objectives: High rates of methicillin-resistant Staphylococcus aureus (MRSA) and fluoroquinolone-resistant Pseudomonas aeruginosa may be related, in part, to the overuse of fluoroquinolones. The objective was to analyse and correlate long-term surveillance data on MRSA and fluoroquinolone-resistant P. aeruginosa rates and antibiotic consumption after implementation of an institution-wide programme to reduce fluoroquinolone use. Methods: An interrupted time series/quasi-experimental study of monthly fluoroquinolone use and MRSA and fluoroquinolone-resistant P. aeruginosa isolation rates was carried out in a tertiary hospital during three periods: pre-intervention (January 2000-August 2005), intervention (September 2005-March 2006), and post-intervention (March 2006-March 2010). The effect of the intervention on the consumption of fluoroquinolones and bacterial resistance was assessed using segmented regression analyses. Results: Mean monthly fluoroquinolone consumption dropped by 29.1 defined daily doses per 1000 patient-days (DDD/1000 PD) (95% CI 13.1-45.9; P = 0.0005) from a mean of 148.2 to 119.1 DDD/1000 PD during the intervention period. A sustained and significant decrease in fluoroquinolone consumption of -0.95 DDD/1000 PD/month was also observed during the post-intervention period (P = 0.0002). During the post-intervention period the rate of fluoroquinolone-resistant P. aeruginosa continuously decreased, from a mean of 42% to 26%, with a constant relative change rate of -13%/year (95% CI -19 to -5, P = 0.001). A decrease in the MRSA rate was observed during the intervention period, from a mean resistance rate of 27% to 21% (P < 0.0001). Conclusions: We showed the sustained impact of a fluoroquinolone control programme on the reduction of fluoroquinolone use with a significant decrease in fluoroquinolone-resistant P. aeruginosa and MRSA rates over 4 years. © The Author 2012. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.


Velazquez A.,Infectious Disease | Deryke C.A.,Pharmacy | Goering R.,Creighton University | Hoover V.,Microbiology | Wallace M.R.,Infectious Disease
Clinical Microbiology and Infection | Year: 2013

Daptomycin non-susceptible Staphylococcus aureus was rarely encountered at our medical centre until 2010, when 10 isolates (0.4% of S. aureus) were confirmed by E-test as non-susceptible. These isolates were not of the same strain type and there was no link between the 10 patients. Daptomycin non-susceptibility may be increasing. © 2013 European Society of Clinical Microbiology and Infectious Diseases.


Wright D.J.M.,Microbiology | Maria B.,Plastic Surgery
Clinical Microbiology and Infection | Year: 2011

Clin Microbiol Infect 2011; 17: 484-486 The contributions of early British colonial and German scientists to the elucidation of the nature of spirochaetes, are contrasted. Recently, after a lapse of nearly three-quarters of a century, there has been a revival of interest by German microbiologists in investigating the borreliae. © 2011 The Authors. Clinical Microbiology and Infection © 2011 European Society of Clinical Microbiology and Infectious Diseases.


Lehmann B.A.,Maastricht University | Ruiter R.A.C.,Maastricht University | Wicker S.,Goethe University Frankfurt | Van Dam D.,Microbiology | Kok G.,Maastricht University
BMC Public Health | Year: 2014

Background: Health Authorities recommend influenza vaccination of healthcare personnel (HCP) to decrease the transmission of influenza to vulnerable patients. Recent studies have almost exclusively used quantitative questionnaires in order to identify determinants of vaccination behaviour. Interviews enable HCP to express freely why they think they are (not) willing to get vaccinated against influenza. Methods. By means of semi-structured one-on-one interviews with 123 Belgian, Dutch and German HCP, reasons for and against vaccination, experiences with influenza vaccination, intention to get vaccinated and possible barriers, as well as willingness to advice influenza vaccination to patients were investigated. Data were processed with QSR NVivo 8.0 and analysed using a combination of a deductive and a general inductive approach. Results: Across countries, self-protection, patient protection, and protection of family members were reported as most important reasons to get vaccinated against influenza. Reasons to not get vaccinated against influenza were fear of side effects caused by the vaccine, a low risk-perception, the disbelief in the effectiveness of influenza vaccination, organizational barriers, misconceptions, and undefined negative emotions. Conclusions: The social cognitive variables underlying the decision of HCP to get vaccinated against influenza (or not) seem to be similar in Belgium, Germany, and the Netherlands, even though some differences surfaced. A quantitative investigation of those social cognitive variables is needed in order to determine the importance of the social cognitive variables in explaining the intention to get vaccinated and the importance of the similarities and differences between countries that have been found in this study. © 2014 Lehmann et al.; licensee BioMed Central Ltd.


Harris K.A.,Microbiology | Kenna D.T.D.,Public Health England
Journal of Medical Microbiology | Year: 2014

Mycobacterium abscessusis a significant pathogen in the cystic fibrosis patient population. PCR amplification and sequencing can provide accurate subspecies identification, and can predict macrolide susceptibility, which is becoming increasingly important for patient management. Molecular techniques for further typing of isolates provide tools for the ongoing investigations into the clinical impact of particular M. abscessusstrains. Whole-genome sequencing is likely to be the only technique that provides sufficient resolution for investigating transmission events between patients. © 2014 The Authors.

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