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Patent
Tokyo Women's Medical University and Microbial Chemistry Research Foundation | Date: 2017-02-08

Provided is a method for detecting the expression of SMN protein, said method comprises:a step for labeling SMN protein in a sample, said sample containing nucleated cells derived from blood;a step for labeling the nuclei of the nucleated cells in the sample;a step for selecting a cell population of the nucleated cells in which nuclei and SMN protein are labeled; anda step for detecting the expression of the SMN protein on the basis of the label for the SMN protein in the selected cell population.


Patent
Intervet International B.V. and Microbial Chemistry Research Foundation | Date: 2017-05-24

This invention relates to solvated and non-solvated crystalline forms of 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide, as well as methods for making such crystalline forms, medicaments comprising (or derived from) such crystalline forms, methods for making medicaments comprising (or derived from) such crystalline forms, methods of treatment using such crystalline forms, and kits comprising such crystalline forms.


Patent
Microbial Chemistry Research Foundation | Date: 2017-03-01

A compound expressed by any one of Structural Formulas (1) to (13), a method for producing the same, and a compound-containing composition, an anti-cancer agent, and an anti-Helicobacter pylori agent each containing the above compound.


Patent
Microbial Chemistry Research Foundation and Colorado State University | Date: 2016-04-13

A drug combination against acid-fast bacillus, including: an inhibitor for WecA or an ortholog thereof; and at least one of an inhibitor for MurX or an ortholog thereof and an RNA synthesis inhibitor, wherein the inhibitor for WecA or an ortholog thereof is used in combination with the at least one of an inhibitor for MurX or an ortholog thereof and an RNA synthesis inhibitor; a screening method for a drug against acid-fast bacillus; and an inhibitor for WecA or an ortholog thereof.


Patent
Meiji Seika Pharma Co. and Microbial Chemistry Research Foundation | Date: 2015-12-30

This invention relates to novel aminoglycoside antibiotics, which have potent antimicrobial activity against bacteria, which induce infectious diseases, particularly MRSA, and has no significant nephrotoxicity, and process for producing them. More particularly, the present invention relates to compounds represented by formula (Ia) or their pharmacologically acceptable salts or solvates, or their diastereomer mixtures, antimicrobial agents comprising them, and a process for producing them.


A method for producing a compound represented by Structural Formula (1), including: introducing benzyl group into trehalose to produce at least one of compound represented by Structural Formula 4a and compound represented by Structural Formula 4a; subjecting at least one of the Structural Formula 4a compound and the Structural Formula 4a compound to prenylation to produce at least one of compound represented by Structural Formula 3a and compound represented by Structural Formula 3a; subjecting at least one of the Structural Formula 3a compound and the Structural Formula 3a compound to sharpless asymmetric dihydroxylation to produce at least one of compound represented by Structural Formula 2a and compound represented by Structural Formula 2a; and allowing at least one of the Structural Formula 2a compound and the Structural Formula 2a compound to react with hydrogen in the presence of palladium catalyst to produce the compound represented by Structural Formula (1).


Patent
Microbial Chemistry Research Foundation | Date: 2015-09-09

An anticancer agent containing ellagitannin, a combination use anticancer agent wherein the anticancer agent and an anticancer agent containing anthracyclines are used in combination.


A method for producing a compound represented by General Formula (1), the method including:reacting a compound represented by General Formula (3) and a compound represented by General Formula (4):^(1) and R^(2) each represent aliphatic group which may have substituent, or aromatic group which may have substituent (with the proviso that R^(1) and R^(2) are different groups), R^(3) represents aromatic group which may have substituent, and R^(4) represents aliphatic group which may have substituent, or aromatic group which may have substituent,^(1) and R^(2) each represent aliphatic group which may have substituent, or aromatic group which may have substituent (with the proviso that R^(1) and R^(2) are different groups), and R^(3) represents aromatic group which may have substituent,^(4) represents aliphatic group which may have substituent, or aromatic group which may have substituent.


Patent
Microbial Chemistry Research Foundation | Date: 2016-01-06

A compound expressed by any one of Structural Formulas (1) to (13), a method for producing the same, and a compound-containing composition, an anti-cancer agent, and an anti-Helicobacter pylori agent each containing the above compound.


Patent
Microbial Chemistry Research Foundation | Date: 2015-03-16

A compound represented by the following General Formula (1): where R^(1 )represents a protective group for a hydroxyl group or a hydrogen atom, and R^(2 )represents a methyl group or an ethyl group.

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