News Article | November 17, 2016
A glut of Zika cases in Puerto Rico suggests that the virus has a preferred victim: women. It’s an idea that has come up before, in previous reports from Brazil and El Salvador. But a new analysis from the U.S. Centers for Disease Control and Prevention adds some heft to the story. Of nearly 30,000 Zika cases in Puerto Rico from November 2015 to October 2016, 63 percent were female, the CDC reported online November 11. This preference is yet another one of Zika’s peculiarities. Two other mosquito-borne diseases, dengue and chikungunya, don’t seem to discriminate between men and women. In previous years in Puerto Rico, cases of these diseases were split evenly. Researchers are still grappling with how to explain the disparity. Zika and all of its mysteries could be on scientists’ radar for the long term. Though infections may soon wind down within the continental United States, case counts are still ticking upwards in some places. Puerto Rico has reported more than 33,000 confirmed cases and Florida is up to 1,169 cases as of November 16. This week, scientists picked up a clue to the gender bias mystery, and learned more about how Zika may be transmitted — and how to clean it up. The vaginal immune systems of mice don’t get riled up for Zika virus, Shazada Khan and colleagues report November 16 in the Journal of Experimental Medicine. Mice infected with Zika in the vagina had a sluggish immune response and didn’t immediately release the virus-fighting molecules that would usually combat Zika. The same was true of another RNA-based virus called LCMV, the researchers found. For these viruses, “vaginal tissue is exceptionally vulnerable to infection,” writes Khan, of the Gladstone Institutes in San Francisco. It’s a possible molecular answer for why women may be at a greater risk for Zika than men. A single mosquito bite may be able to transmit both Zika and chikungunya at the same time, Claudia Rückert, Greg Ebel and colleagues reported November 14 at the annual meeting of the American Society of Tropical Medicine and Hygiene in Atlanta. Researchers let mosquitoes feed on blood spiked with chikungunya, Zika or both. The team then measured the amount of each virus in the mosquitoes’ saliva. Mosquitoes infected with only Zika virus had about the same number of Zika genome copies in their saliva as those infected with both viruses. The same was true for chikungunya. Basically, the doubly infected mosquitoes were carrying a double load of virus, says Rückert, of Colorado State University in Fort Collins. That could mean that mosquitoes are spreading two diseases from person to person, she says. Zika can survive for at least eight hours in dried blood on a glass surface, researchers reported November 15 at the annual meeting of the American Association of Pharmaceutical Scientists in Denver. When the team scraped the glass clean and added the virus and blood mixture to monkey kidney cells, it was still infectious. But the virus isn’t invincible. Washing the blood-stained glass with 70 percent isopropyl alcohol for 15 seconds was enough to inactivate 99.999 percent of the virus, says virologist Steve Zhou of a division of Microbac Laboratories Inc. in Sterling, Va.
News Article | February 20, 2017
The report "Top 10 Food Safety Testing and Technologies Trends (Food Safety, GM Food Safety, Food Pathogen, Meat Speciation, Food Authenticity, Pesticide Residue, Mycotoxin, Allergen, Water, and Bottled Water) - Global Forecast to 2022", published by Markets and Markets, the market is projected to reach USD 39.47 Billion by 2022 Browse 130 market data Tables and 117 Figures spread through 335 Pages and in-depth TOC on "Top 10 Food Safety Testing and Technologies Trends" http://www.marketsandmarkets.com/Market-Reports/top-10-food-safety-testing-technologies-trends-19285603.html Early buyers will receive 10% customization on this report. The Food Safety Testing and Technologies Market encompasses a variety of testing technologies. The markets covered under food safety testing include food safety testing market, GM food safety testing market, food pathogen testing market, meat speciation testing market, food authenticity testing market, pesticide residue testing market, mycotoxin testing market, and food allergen testing market. The markets covered under water safety testing & technologies include water testing and analysis and bottled water testing. The meat speciation testing market is projected to grow at the highest CAGR of 8.2% to reach a value of USD 2.22 Billion by 2022. The pathogen testing market is the largest market and is projected to reach USD 12.54 Billion by 2022. The food safety testing market is projected to reach USD 18.41 Billion by 2022 The food safety testing market is estimated to be valued at USD 12.01 billion in 2016. The various factors that drive the food safety testing market include worldwide increase in foodborne illness outbreaks, implementation of stringent food safety regulations by the government, and availability of advanced technologies capable of rapid testing. Globalization of food supply that has resulted in an increased export and import of food products and agricultural commodities worldwide is another driver influencing this market. The mycotoxin testing market is projected to grow at a CAGR of 6.0%, from 2016 to 2022 The global mycotoxin testing market is projected to grow at a CAGR of 6.0% to reach a value of USD 1.56 billion by 2022. Growth in awareness of consumers with regard to food safety is the most important driver for this market. There have been several food recalls due to the presence of mycotoxin in the food products resulting in increased attention toward this market. Government regulations also play a major driver in this market as several countries have stringent government regulations and there are regulatory authorities that check if the food product is free from mycotoxins and fit for human and animal consumption. This report includes a study of marketing and development strategies, along with the product portfolios of the leading companies. It includes profiles of leading companies such as SGS S.A. (Switzerland), Bureau Veritas S.A. (France), Intertek Group plc (U.K.), Eurofins Scientific SE (Luxembourg), ALS Limited (Australia), Thermo Fisher Scientific Inc. (U.S.), Mérieux NutriSciences Corporation (U.S.), AsureQuality Ltd. (New Zealand), Microbac Laboratories Inc. (U.S.), and Romer Labs Diagnostic GmbH (Austria). Food Safety Testing Market by Contaminant (Pathogens, Pesticides, GMOs, and Toxins), Food Tested (Meat & Poultry, Dairy Product, Processed Food, and Fruits & Vegetables), Technology (Traditional and Rapid), and by Region - Global Forecast to 2021 http://www.marketsandmarkets.com/Market-Reports/food-safety-365.html Genetically Modified Food Safety Testing Market by Trait (Stacked, Herbicide Tolerance, Insect Resistance), Technology (Polymerase Chain Reaction, Immunoassay), Crop & Processed Food Tested & by Region - Global Trend & Forecast to 2020 http://www.marketsandmarkets.com/Market-Reports/genetically-modified-food-safety-testing-market-101319111.html MarketsandMarkets is the largest market research firm worldwide in terms of annually published premium market research reports. Serving 1700 global fortune enterprises with more than 1200 premium studies in a year, M&M is catering to a multitude of clients across 8 different industrial verticals. We specialize in consulting assignments and business research across high growth markets, cutting edge technologies and newer applications. Our 850 fulltime analyst and SMEs at MarketsandMarkets are tracking global high growth markets following the "Growth Engagement Model - GEM". The GEM aims at proactive collaboration with the clients to identify new opportunities, identify most important customers, write "Attack, avoid and defend" strategies, identify sources of incremental revenues for both the company and its competitors. M&M's flagship competitive intelligence and market research platform, "RT" connects over 200,000 markets and entire value chains for deeper understanding of the unmet insights along with market sizing and forecasts of niche markets. The new included chapters on Methodology and Benchmarking presented with high quality analytical infographics in our reports gives complete visibility of how the numbers have been arrived and defend the accuracy of the numbers. 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Hauger B.E.,Microbac Laboratories Inc.
Society of Plastics Engineers - 2013 SPE International Polyolefins Conference | Year: 2013
The potential for contamination of potable water by the aromatic components of gasoline, namely benzene, toluene, ethylbenzene, and xylenes (BTEX), is of enduring concern due to their well-known health effects. Permeation of BTEX through plastic pipe and the elastomeric gaskets used in the assembly of some pipe systems has been discussed and debated in academic literature for years. Recently, new insights have been gained through studies of water piping systems by using Fick's Law and relevant engineering variables. This paper will review the state-of-the-art regarding the important question of how various water systems may be affected by hydrocarbon permeation.
Hauger B.E.,Microbac Laboratories Inc. |
Ferry S.,Microbac Laboratories Inc. |
Willacker R.,Microbac Laboratories Inc.
Annual Technical Conference - ANTEC, Conference Proceedings | Year: 2013
Plastic pipe components are generally constructed into high integrity, high durability systems. However, some poor installation practices occur with sufficient frequency that they have been noted by the authors as recurring as the root cause upon completion of failure analyses. These installation based root causes differ with the application environment and the material of construction. This paper will address poor installation practices for polyethylene, poly vinyl chloride and chlorinated poly vinyl chloride based piping systems.
Bashir M.H.,Microbac Laboratories Inc. |
Olson L.K.M.,3M |
American Journal of Infection Control | Year: 2012
Background: Catheter colonization and bloodstream infection during the first week after insertion of a central venous catheter have been shown to result from the patient's own skin flora. Methods: The backs of 32 healthy subjects were prepped with a 2% chlorhexidine gluconate (CHG)/70% isopropyl alcohol antiseptic. Three dressings, 2 of which contained CHG, were placed on the prepped skin in a randomized design. Samples of aerobic bacteria were collected using the cup scrub method. Skin under the dressings was sampled by quadrant on days 1, 4, and 7. Relative suppression of regrowth was compared using an adjusted paired t test. Results: Mean log counts were 3.2 log 10 colony-forming units (CFU)/cm 2 before antisepsis and 0.4 after antisepsis. Mean log counts obtained on days 1, 4, and 7 were 0.4, 0.3, and 0.5 log 10 CFU/cm 2 for the CHG gel; 0.4, 0.4, and 0.9 log 10 CFU/cm 2 for the CHG disk; and 0.9, 1.2, and 1.5 log 10 CFU/cm 2 for the Control, respectively. Conclusion: Skin flora was not completely eradicated during antisepsis, and bacterial regrowth occurred postantisepsis. The use of CHG dressings helped sustain a reduced bacterial count on the skin. The continuously releasing CHG gel maintained suppression to a greater extent than the CHG disk at 7 days (P =.01). © 2012 by the Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.
Edmonds S.L.,GOJO Industries Inc. |
Mccormack R.R.,BioScience Laboratories Inc. |
Zhou S.S.,Microbac Laboratories Inc. |
Macinga D.R.,GOJO Industries Inc. |
Fricker C.M.,GOJO Industries Inc.
Journal of Food Protection | Year: 2012
Pathogenic strains of Escherichia coli and human norovirus are the main etiologic agents of foodborne illness resulting from inadequate hand hygiene practices by food service workers. This study was conducted to evaluate the antibacterial and antiviral efficacy of various hand hygiene product regimens under different soil conditions representative of those in food service settings and assess the impact of product formulation on this efficacy. On hands contaminated with chicken broth containing E. coli, representing a moderate soil load, a regimen combining an antimicrobial hand washing product with a 70% ethanol advanced formula (EtOH AF) gel achieved a 5.22-log reduction, whereas a nonantimicrobial hand washing product alone achieved a 3.10- log reduction. When hands were heavily soiled from handling ground beef containing E. coli, a wash-sanitize regimen with a 0.5% chloroxylenol antimicrobial hand washing product and the 70% EtOH AF gel achieved a 4.60-log reduction, whereas a wash-sanitize regimen with a 62% EtOH foam achieved a 4.11-log reduction. Sanitizing with the 70% EtOH AF gel alone was more effective than hand washing with a nonantimicrobial product for reducing murine norovirus (MNV), a surrogate for human norovirus, with 2.60- and 1.79-log reductions, respectively. When combined with hand washing, the 70% EtOH AF gel produced a 3.19-log reduction against MNV. A regimen using the SaniTwice protocol with the 70% EtOH AF gel produced a 4.04-log reduction against MNV. These data suggest that although the process of hand washing helped to remove pathogens from the hands, use of a wash-sanitize regimen was even more effective for reducing organisms. Use of a high-efficacy sanitizer as part of a wash-sanitize regimen further increased the efficacy of the regimen. The use of a well-formulated alcohol-based hand rub as part of a wash-sanitize regimen should be considered as a means to reduce risk of infection transmission in food service facilities. Copyright © International Association for Food Protection.
Kampf G.,Bode Chemie GmbH |
Kampf G.,University of Greifswald |
Ruselack S.,Bode Chemie GmbH |
Eggerstedt S.,Bode Chemie GmbH |
And 2 more authors.
BMC Infectious Diseases | Year: 2013
Background: Some manufacturers recommend using 1.1 mL per application of alcohol-based handrubs for effective hand disinfection. However, whether this volume is sufficient to cover both hands, as recommended by the World Health Organization, and fulfills current efficacy standards is unknown. This study aimed to determine hand coverage for three handrubs (two gels based on 70% v/v and 85% w/w ethanol and a foam based on 70% v/v ethanol) applied at various volumes.Methods: Products were tested at product volumes of 1.1 mL, 2 mL, 2.4 mL as well as 1 and 2 pump dispenser pushes; the foam product was tested in addition at foam volumes of 1.1 mL, 2 mL, and 2.4 mL. Products were supplemented with a fluorescent dye and 15 participants applied products using responsible application techniques without any specific steps but the aim of completely covering both hands. Coverage quality was determined under ultraviolet light by two blinded investigators. Efficacy of the three handrubs was determined according to ASTM E 1174-06 and ASTM E 2755-10. For each experiment, the hands of 12 participants were contaminated with Serratia marcescens and the products applied as recommended (1.1 mL for 70% v/v ethanol products; 2 mL for the 85% w/w ethanol product). Log10-reduction was calculated.Results: Volumes < 2 mL yielded high rates of incomplete coverage (67%-87%) whereas volumes ≥ 2 mL gave lower rates (13%-53%). Differences in coverage were significant between the five volumes tested for all handrubs (p < 0.001; two-way ANOVA) but not between the three handrubs themselves (p = 0.796). Application of 1.1 mL of 70% v/v ethanol rubs reduced contamination by 1.85 log10 or 1.60 log10 (ASTM E 1174-06); this failed the US FDA efficacy requirement of at least 2 log10. Application of 2 mL of the 85% w/w ethanol rub reduced contamination by 2.06 log10 (ASTM E 1174-06), fulfilling the US FDA efficacy requirement. Similar results were obtained according to ASTM E 2755-10.Conclusions: Our data indicated that handrubs based on 70% ethanol (v/v) with a recommended volume of 1.1 mL per application do not ensure complete coverage of both hands and do not achieve current ASTM efficacy standards. © 2013 Kampf et al.; licensee BioMed Central Ltd.
Borkow G.,Cupron Scientific |
Zhou S.S.,Microbac Laboratories Inc. |
Page T.,Cupron Scientific |
Gabbay J.,Cupron Scientific
PLoS ONE | Year: 2010
Background Protective respiratory face masks protect the nose and mouth of the wearer from vapor drops carrying viruses or other infectious pathogens. However, incorrect use and disposal may actually increase the risk of pathogen transmission, rather than reduce it, especially when masks are used by non-professionals such as the lay public. Copper oxide displays potent antiviral properties. A platform technology has been developed that permanently introduces copper oxide into polymeric materials, conferring them with potent biocidal properties. Methodology/Principal Findings We demonstrate that impregnation of copper oxide into respiratory protective face masks endows them with potent biocidal properties in addition to their inherent filtration properties. Both control and copper oxide impregnated masks filtered above 99.85% of aerosolized viruses when challenged with 5.66±0.51 and 6.17±0.37 log10TCID50 of human influenza A virus (H1N1) and avian influenza virus (H9N2), respectively, under simulated breathing conditions (28.3 L/min). Importantly, no infectious human influenza A viral titers were recovered from the copper oxide containing masks within 30 minutes (≤0.88 log10TCID50), while 4.67±1.35 log10TCID50 were recovered from the control masks. Similarly, the infectious avian influenza titers recovered from the copper oxide containing masks were ≤0.97±0.01 log10TCID50 and from the control masks 5.03±0.54 log10TCID50. The copper oxide containing masks successfully passed Bacterial Filtration Efficacy, Differential Pressure, Latex Particle Challenge, and Resistance to Penetration by Synthetic Blood tests designed to test the filtration properties of face masks in accordance with the European EN 14683:2005 and NIOSH N95 standards.Conclusions/Significance Impregnation of copper oxide into respiratory protective face masks endows them with potent anti-influenza biocidal properties without altering their physical barrier properties. The use of biocidal masks may significantly reduce the risk of hand or environmental contamination, and thereby subsequent infection, due to improper handling and disposal of the masks.© 2010.
PubMed | Microbac Laboratories Inc.
Type: Journal Article | Journal: American journal of infection control | Year: 2012
Catheter colonization and bloodstream infection during the first week after insertion of a central venous catheter have been shown to result from the patients own skin flora.The backs of 32 healthy subjects were prepped with a 2% chlorhexidine gluconate (CHG)/70% isopropyl alcohol antiseptic. Three dressings, 2 of which contained CHG, were placed on the prepped skin in a randomized design. Samples of aerobic bacteria were collected using the cup scrub method. Skin under the dressings was sampled by quadrant on days 1, 4, and 7. Relative suppression of regrowth was compared using an adjusted paired t test.Mean log counts were 3.2 log(10) colony-forming units (CFU)/cm(2) before antisepsis and 0.4 after antisepsis. Mean log counts obtained on days 1, 4, and 7 were 0.4, 0.3, and 0.5 log(10) CFU/cm(2) for the CHG gel; 0.4, 0.4, and 0.9 log(10) CFU/cm(2) for the CHG disk; and 0.9, 1.2, and 1.5 log(10) CFU/cm(2) for the Control, respectively.Skin flora was not completely eradicated during antisepsis, and bacterial regrowth occurred postantisepsis. The use of CHG dressings helped sustain a reduced bacterial count on the skin. The continuously releasing CHG gel maintained suppression to a greater extent than the CHG disk at 7 days (P = .01).
PubMed | Microbac Laboratories Inc. and Circle Inc.
Type: Journal Article | Journal: Biologicals : journal of the International Association of Biological Standardization | Year: 2016
The use of specific model viruses for validating viral purification process steps and for assessing the efficacies of viral disinfectants is based, in part, on the assumption that viral susceptibilities to such treatments will be similar for different members, including different genera, within a given viral family. This assumption is useful in cases where cell-based infectivity assays or laboratory strains for the specific viruses of interest might not exist. There are some documented cases, however, where exceptions to this assumption exist. In this paper, we discuss some of the more striking cases of intra-family differences in susceptibilities to inactivation steps used for downstream viral purification steps in biologics manufacture (e.g. heat inactivation, low pH, and guanidinium hydrochloride inactivation) and to specific viral disinfectants (e.g. alcohols, hydrogen peroxide, and quaternary ammonium-containing disinfectants) that might be employed for facility/equipment disinfection. The results suggest that care should be taken when extrapolating viral inactivation susceptibilities from specific model viruses to different genera or even to different members of the same genus. This should be taken into consideration by regulatory agencies and biologics manufacturers designing viral clearance and facility disinfection validation studies, and developers and evaluators of viral disinfectants.