MicroAlgae Corporation

Gifu-shi, Japan

MicroAlgae Corporation

Gifu-shi, Japan
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Tanioka Y.,Tokyo University of Agriculture | Bito T.,Tottori University | Takeuchi T.,Tottori University | Takenaka H.,MicroAlgae Corporation | And 4 more authors.
Nippon Shokuhin Kagaku Kogaku Kaishi | Year: 2017

A hot water extract was preparedfrom the edible cyanobacterium Nostochopsis sp., andwas chemically and biologically characterized. The hot water extract mainly contained carbohydrate (approximately 52.3 g/100g dry weight), most of which was derived from soluble dietary fiber consisting of neutral (mainly glucose, fucose, and mannose) andacidsugars. The hot water extract showeda high viscosity (1.90 mPa·s) at 0.1% (w/v) concentration. Bloodglucose levels of 0.5% (w/v) hot water extract-treatedrats decreasedsignificantly at 30 min after administration of maltose solution relative to controls. These results suggest that Nostochopsis sp. hot water extract is able to delay the increase in postprandial bloodglucose levels.


Yabuta Y.,Agricultural | Hashimoto E.,Agricultural | Takeuchi T.,Tottori University | Sakaki S.,MicroAlgae Corporation | And 3 more authors.
Food Science and Technology Research | Year: 2014

Cyanobacteria contain substances of high biological value and are used to meet the high demands of the global food and pharmaceutical industries. In this study, we prepared a hot water extract of the edible cyanobacterium, Nostochopsis, and evaluated its possible use as an ingredient in cosmetics. Specifically, a hot water extract of Nostochopsis was assayed for tyrosinase inhibitory activity. Tyrosinase, a key enzyme in skin melanin synthesis, was strongly inhibited by the Nostochopsis hot water extract, which reduced a-melanocyte-stimulating hormone-induced melanin synthesis in B16 mouse melanoma cells. Thus, Nostochopsis hot water extract may be suitable as an ingredient in cosmetics. Copyright © 2014, Japanese Society for Food Science and Technology.


Itoh T.,Kinki University | Tsuzuki R.,Kinki University | Tanaka T.,Kinki University | Ninomiya M.,Gifu University | And 5 more authors.
Food and Chemical Toxicology | Year: 2013

Nostoc commune is a terrestrial benthic blue-green alga that often forms an extended mucilaginous layer on the soil, accumulates on stones and mud in aquatic environments. Reduced-scytonemin (R-scy), isolated from N. commune Vaucher, has been shown to suppress the human T-lymphoid Jurkat cell growth. To reveal the mechanisms underlying the R-scy-mediated inhibition of Jurkat cell growth, we examined cell morphology, DNA fragmentation, and microtubule-associated protein light chain 3 (LC3) modification in these cells. We observed multiple vacuoles as well as the conversion of LC3-I to LC3-II in R-scy-treated cells. These results suggest that the R-scy induced Jurkat cell growth inhibition is attributable to the induction of type II programmed cell death (PCD II; autophagic cell death or autophagy). We further examined the mechanisms underlying R-scy-induced PCDII. The cells treated with R-scy produced large amounts of reactive oxygen species (ROS), leading to the induction of mitochondrial dysfunction. However, the elimination of R-scy-induced ROS by treatment with N-acetyl-. l-cysteine (NAC) markedly opposed R-scy-induced PCDII. Based on these results, we conclude that ROS formation plays a critical role in R-scy-induced PCDII. © 2013 Elsevier Ltd.


Hashimoto E.,Tottori University | Yabuta Y.,Tottori University | Takenaka S.,Osaka Prefecture University | Yamaguchi Y.,MicroAlgae Corporation | And 2 more authors.
Journal of Nutritional Science and Vitaminology | Year: 2012

Vitamin B12 content of an edible cyanobacterium, Nostochopsis sp. was determined to be 140.6±16.2 μg/100 g dry weight by a microbiological method. To evaluate whether the Nostochopsis cells contain vitamin B12 or inactive corrinoid compounds, corrinoid compounds were purified from the cells and then identified as pseudovitamin B12 (97.4±11.8 μg/100 g dry weight) and vitamin B12 (43.2±6.0 μg/100 g dry weight) on the basis of silica gel 60 TLC bioautograms and LC/ESI-MS/MS chromatograms. Vitamin B12 content was significantly increased in the Nostochopsis cells (254.8±17.6 μg/100 g dry weight) grown in the vitamin B12-supplemented medium.

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