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Martinez-Perdiguero J.,CIC microGUNE | Retolaza A.,CIC microGUNE | Retolaza A.,Micro and Nanofabrication Unit | Otaduy D.,CIC microGUNE | And 5 more authors.
Sensors (Switzerland) | Year: 2013

In this work we present a surface plasmon resonance sensor based on enhanced optical transmission through sub-wavelength nanohole arrays. This technique is extremely sensitive to changes in the refractive index of the surrounding medium which result in a modulation of the transmitted light. The periodic gold nanohole array sensors were fabricated by high-throughput thermal nanoimprint lithography. Square periodic arrays with sub-wavelength hole diameters were obtained and characterized. Using solutions with known refractive index, the array sensitivities were obtained. Finally, protein absorption was monitored in real-time demonstrating the label-free biosensing capabilities of the fabricated devices. © 2013 by the authors; licensee MDPI, Basel, Switzerland.

Baran E.T.,European Institute of Excellence on Tissue Engineering and Regenerative Medicine | Baran E.T.,ICVS 3Bs PT Government Associated Laboratory | Pirraco R.P.,European Institute of Excellence on Tissue Engineering and Regenerative Medicine | Pirraco R.P.,ICVS 3Bs PT Government Associated Laboratory | And 10 more authors.
Journal of Bioactive and Compatible Polymers | Year: 2015

In this study, cell responses on micropatterned films that were changing in groove-ridge widths and pattern depth were investigated to compare the degree of size effects from X-Y and Z planes. Poly(caprolactone) films with five different groove-ridge sizes and three pattern depths were prepared by hot embossing technique. In general, the morphologies of osteoblast cell were not changed noticeably by the size changes in groove-ridges with the same depth size. However, cell morphologies were changed significantly when pattern depths were increased from 1.35 to 4.95‰μm. Also, the cell morphology change between different groove-ridges was significant when the pattern depth was small (1.35‰μm), and these effects were diminished or masked when the pattern depth was increased to 4.95‰μm. Linear regression analysis further clarifies that unit size changes in depth may affect cell length and orientation rates 2.4 and 4 times, respectively, in comparison to rates obtained from X-Y planes. © SAGE Publications.

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