Michigan Biotechnology Institute

Lake Michigan Beach, MI, United States

Michigan Biotechnology Institute

Lake Michigan Beach, MI, United States
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The MSU Foundation's ongoing economic development initiatives focus on taking Michigan State University's faculty and researcher technologies to market, investing in MSU student entrepreneurs, and working with area partners to build and grow the region's robust, thriving culture of innovation. "Our mission at Renaissance is to serve as a bridge between researchers, entrepreneurs, venture capitalists, and major corporations in Michigan," said Chris Rizik, chief executive officer of Renaissance Venture Capital Fund. "We are impressed with the growth of innovation efforts at Michigan State University and are excited to extend our presence and network in the region." The TIC, managed and operated by the MSU Foundation, offers its tech-based members office space, programmatic support, and resources aimed at helping startups and early-stage companies flourish. The TIC is adjacent to the MSU Innovation Center. About the Renaissance Venture Capital Fund The Renaissance Venture Capital Fund is a fund of funds that supports the growth of venture capital in Michigan while serving as a bridge between Michigan's emerging innovation company community and its strong industrial and commercial base. Formed by Business Leaders for Michigan, the Renaissance Venture Capital Fund boasts as its members many of Michigan's most important organizations. It has become a national model for strategic, financially successful regional investing. Through its investment in top tier venture firms that are active in Michigan, as well as its own co-investments in emerging Michigan companies, the Renaissance Venture Capital Fund is helping to drive forward both innovation and growth of emerging companies in the region. And it is again proving that Michigan, with its unique combination of scientific, engineering and business talent, is a great place in which to invest. For more information, please visit: www.renvcf.com. About the Michigan State University Foundation Established in 1973 as an independent, non-profit corporation, the Michigan State University Foundation fuels economic development initiatives through the commercialization of cutting-edge technologies invented by Michigan State University faculty, staff, and students. At its core is an extensive program, focusing on the support of research, invention, and entrepreneurship. The Michigan State University Foundation operates Michigan Biotechnology Institute, Red Cedar Ventures, Spartan Innovations, and the University Corporate Research Park. Further, the Foundation manages and operates the East Lansing Technology Innovation Center. More information on the Foundation's notable achievements, provided services, key leadership, and history are available at www.msufoundation.org About the East Lansing Technology Innovation Center Founded in 2008, right in the heart of downtown East Lansing, the East Lansing Technology Innovation Center, also known as the TIC, became the first business incubator in the region. Today, the space continues to be home to technology startup companies, offering them support and space to grow their ideas. Members have direct access to resources within the MSU Innovation Center, as well as Michigan State University's campus. Connecting members with a vast network of area professionals, community resources, and venture capitalists, the TIC offers the space for tech entrepreneurs to explore their ideas, take creative risks, and grow their networks. For more about the East Lansing Technology Innovation Center, please visit: www.eastlansingtic.org. To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/renaissance-venture-capital-fund-expands-to-east-lansing-technology-innovation-center-300454760.html


Williams D.L.,Michigan State University | Wynn J.,Michigan Biotechnology Institute | Liu T.,Michigan State University | Hodge D.,Michigan State University
10AIChE - 2010 AIChE Annual Meeting, Conference Proceedings | Year: 2010

This work will investigate the feasibility of biomass pretreatment with alkaline hydrogen peroxide (AHP) in a cellulosic ethanol process with the ultimate goal of optimizing the utilization of input chemicals for an industrially relevant process for the pretreatment of herbaceous plants. For economic feasibility, pretreatment must be done at higher solids loadings; therefore, input chemical utilization must be optimized by determining the consumption of alkali and hydrogen peroxide at high solids concentrations. An understanding of the relationship between NaOH: H2O2: Biomass and enzymatic digestibility will be developed to determine if economically feasible conditions for AHP can be identified. Using these conditions, an economic analysis of a cellulosic ethanol plant utilizing 1000 ton/day of switchgrass pretreated by AHP will be performed based on the experimentally-determined biomass digestibilities and inorganic chemical consumptions.


Bonner I.J.,Idaho National Laboratory | Thompson D.N.,Idaho National Laboratory | Plummer M.,Idaho National Laboratory | Dee M.,Idaho National Laboratory | And 5 more authors.
Drying Technology | Year: 2016

Pretreatment and densification of biomass can increase the viability of bioenergy production by providing a feedstock that is readily hydrolyzed and able to be transported over greater distances. Ammonia fiber expansion (AFEX™) is one such method targeted for use at distributed depots to create a value-added and densified feedstock for bioenergy use. However, the pretreatment process results in a high-moisture material that must be dried, further size reduced, and pelletized, all of which are energy-intensive processes. This work quantifies the energy consumption required to dry, grind, and densify AFEX-pretreated corn stover compared to non-pretreated stover and explores the potential of reduced drying as a means to conserve energy. The purpose of this work is to understand whether material property changes resulting from AFEX pretreatment influence the material performance in downstream formatting operations. Material properties, heat balance equations, and a rotary drum dryer model were used to model a commercial-scale rotary drum dryer for AFEX-pretreated corn stover, showing the potential to reduce dryer energy consumption by up to 36% compared to non-pretreated corn stover. Laboratory-measured grinding and pelleting energies were both very sensitive to material moisture content. Overall, the total energy required for drying, grinding, and pelleting amounts to a savings of up to 23 kWh/dry Mg for the AFEX-pretreated material when dried to a low moisture content, equating to up to 0.61 $/Mg savings for gas and electricity. Grinding and pelleting of high-moisture AFEX-pretreated stover was shown to be more costlier than the savings collected through reduced drying. Although the energy and cost savings shown here are modest, the results help to highlight operational challenges and opportunities for continued improvement. 2016 Copyright © Taylor & Francis Group, LLC


Bonner I.J.,Idaho National Laboratory | Thompson D.N.,Idaho National Laboratory | Teymouri F.,Michigan Biotechnology Institute | Campbell T.,Michigan Biotechnology Institute | And 2 more authors.
Drying Technology | Year: 2015

Combining ammonia fiber expansion (AFEX™) pretreatment with a depot processing facility is a promising option for delivering high-value densified biomass to the emerging bioenergy industry. However, because the pretreatment process results in a high moisture material unsuitable for pelleting or storage (40% wet basis), the biomass must be immediately dried. If AFEX pretreatment results in a material that is difficult to dry, the economics of this already costly operation would be at risk. This work tests the nature of moisture sorption isotherms and thin-layer drying behavior of corn (Zea mays L.) stover at 20°C to 60°C before and after sequential AFEX pretreatment and pelletization to determine whether any negative impacts to material drying or storage may result from the AFEX process. The equilibrium moisture content to equilibrium relative humidity relationship for each of the materials was determined using dynamic vapor sorption isotherms and modeled with modified Chung-Pfost, modified Halsey, and modified Henderson temperature-dependent models as well as the Double Log Polynomial (DLP), Peleg, and Guggenheim Anderson de Boer (GAB) temperature-independent models. Drying kinetics were quantified under thin-layer laboratory testing and modeled using the Modified Page's equation. Water activity isotherms for non-pelleted biomass were best modeled with the Peleg temperature-independent equation while isotherms for the pelleted biomass were best modeled with the Double Log Polynomial equation. Thin-layer drying results were accurately modeled with the Modified Page's equation. The results of this work indicate that AFEX pretreatment results in drying properties more favorable than or equal to that of raw corn stover, and pellets of superior physical stability in storage. © 2015, This article not subject to United States copyright law.


Lamers P.,Idaho National Laboratory | Roni M.S.,Idaho National Laboratory | Tumuluru J.S.,Idaho National Laboratory | Jacobson J.J.,Idaho National Laboratory | And 5 more authors.
Bioresource Technology | Year: 2015

Decentralized biomass processing facilities, known as biomass depots, may be necessary to achieve feedstock cost, quantity, and quality required to grow the future U.S. bioeconomy. In this paper, we assess three distinct depot configurations for technical difference and economic performance. The depot designs were chosen to compare and contrast a suite of capabilities that a depot could perform ranging from conventional pelleting to sophisticated pretreatment technologies. Our economic analyses indicate that depot processing costs are likely to range from ~US$30 to US$63 per dry metric tonne (Mg), depending upon the specific technology implemented and the energy consumption for processing equipment such as grinders and dryers. We conclude that the benefits of integrating depots into the overall biomass feedstock supply chain will outweigh depot processing costs and that incorporation of this technology should be aggressively pursued. © 2015 Published by Elsevier Ltd.


Patent
Michigan Biotechnology Institute | Date: 2012-06-06

Disclosed are recombinant microorganisms for producing organic acids. The recombinant microorganisms express a polypeptide that has the enzymatic activity of an enzyme that is utilized in the pentose phosphate cycle. The recombinant microorganism may include recombinant Actinobacillus succinogenes that has been transformed to express a Zwischenferment (Zwf) gene. The recombinant microorganisms may be useful in fermentation processes for producing organic acids such as succinic acid and lactic acid. Also disclosed are novel plasmids that are useful for transforming microorganisms to produce recombinant microorganisms that express enzymes such as Zwf.


Patent
Michigan Biotechnology Institute | Date: 2013-04-24

this invention is directed to a process for treating biomass. The biomass is treated with a biomass swelling agent within the vessel to swell or rupture at least a portion of the biomass. A portion of the swelling agent is removed from a first end of the vessel following the treatment. Then steam is introduced into a second end of the vessel different from the first end to further remove swelling agent from the vessel in such a manner that the swelling agent exits the vessel at a relatively low water content.


PubMed | Michigan Biotechnology Institute and Idaho National Laboratory
Type: | Journal: Bioresource technology | Year: 2015

Decentralized biomass processing facilities, known as biomass depots, may be necessary to achieve feedstock cost, quantity, and quality required to grow the future U.S. bioeconomy. In this paper, we assess three distinct depot configurations for technical difference and economic performance. The depot designs were chosen to compare and contrast a suite of capabilities that a depot could perform ranging from conventional pelleting to sophisticated pretreatment technologies. Our economic analyses indicate that depot processing costs are likely to range from US$30 to US$63 per dry metric tonne (Mg), depending upon the specific technology implemented and the energy consumption for processing equipment such as grinders and dryers. We conclude that the benefits of integrating depots into the overall biomass feedstock supply chain will outweigh depot processing costs and that incorporation of this technology should be aggressively pursued.


Patent
Michigan Biotechnology Institute | Date: 2011-12-16

Disclosed are recombinant microorganisms for producing organic acids. The recombinant microorganisms express a polypeptide that has the enzymatic activity of an enzyme that is utilized in the pentose phosphate cycle. The recombinant microorganism may include recombinant Actinobacillus succinogenes that has been transformed to express a Zwischenferment (Zwf) gene. The recombinant microorganisms may be useful in fermentation processes for producing organic acids such as succinic acid and lactic acid. Also disclosed are novel plasmids that are useful for transforming microorganisms to produce recombinant microorganisms that express enzymes such as Zwf.


Patent
Michigan Biotechnology Institute | Date: 2011-03-03

This invention provide processes for producing carboxylic acid product, along with useful salts. The carboxylic acid product that is produced according to this invention is preferably a C_(2)-C_(12 )carboxylic acid. Among the salts produced in the process of the invention are ammonium salts.

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