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Dolphin I.,Sakai Foundation | Arbor A.,Michigan
Proceedings: DMS 2011 - 17th International Conference on Distributed Multimedia Systems | Year: 2011

From its origins in 2003 as a grant funded project, Sakai has become a successful open source community, with over three hundred adoptions worldwide, and a growing ecosystem of community and commercial support. Over the same period, economic, policy and technology landscape changes, have dramatically modified the context against which an open source community rooted in Higher Education operates.The Sakai community is dealing with these challenges of this changed context on multiple levels.The development of an innovative software environment, the Sakai Open Academic Environment, embodying an application of the experience of social networking to the online support of academic practice, and applying lessons of web-scale software development to that environment. Driven by community requirements, the project is providing a bridging layer from the established Sakai Collaboration and Learning Environment to the Open Academic Environment, thus allowing institutions to plan environmental transitions, or extend institutional capacity in support of online learning into social space.The transformation of the Sakai Foundation, which is the organisational locus of Sakai community organisation, to sustainably support multiple software projects. This is taking place both internally, and by building new relationships with other open source communities. © 2011 by Knowledge Systems Institute Graduate School.

In just a decade, optoacoustic or photoacoustic imaging has become one of the fastest growing areas of biomedical technology, exploding from just a handful of research groups in the late 1990s to more than 400 dedicated scientists and engineers today. Much of the expansion has come since researchers started pairing optoacoustics with the already-existing technology of medical ultrasound and envisioning how it could easily step into the clinic to fight a diversity of diseases. © 2015 IEEE.

Giorgini P.,University of L'Aquila | Rubenfire M.,University of Michigan | Das R.,University of Michigan | Gracik T.,University of Michigan | And 7 more authors.
Journal of Hypertension | Year: 2015

Objective: Fine particulate matter air pollution (PM 2.5) and extreme temperatures have both been associated with alterations in blood pressure (BP). However, few studies have evaluated their joint haemodynamic actions among individuals at high risk for cardiovascular events. Methods: We assessed the effects of short-term exposures during the prior week to ambient PM 2.5 and outdoor temperature levels on resting seated BP among 2078 patients enrolling into a cardiac rehabilitation programme at the University of Michigan (from 2003 to 2011) using multiple linear regression analyses adjusting for age, sex, BMI, ozone and the same-day alternate environmental factor (i.e. PM 2.5 or temperature). Results: Mean PM 2.5 and temperature levels were 12.6±8.2μg/m 3 and 10.3±10.4°C, respectively. Each standard deviation elevation in PM 2.5 concentration during lag days 4-6 was associated with significant increases in SBP (2.1-3.5mmHg) and DBP (1.7-1.8mmHg). Conversely, higher temperature levels (per 10.4°C) during lag days 4-6 were associated with reductions in both SBP (-3.6 to -2.3mmHg) and DBP (-2.5 to -1.8mmHg). There was little evidence for consistent effect modification by other covariates (e.g. demographics, seasons, medication usage). Conclusion: Short-term exposures to PM 2.5, even at low concentrations within current air quality standards, are associated with significant increases in BP. Contrarily, higher ambient temperatures prompt the opposite haemodynamic effect. These findings demonstrate that both ubiquitous environmental exposures have clinically meaningful effects on resting BP among high-risk cardiac patients. © 2015 Wolters Kluwer Health, Inc.

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