Umuahia, Nigeria

The Michael Okpara University of Agriculture, originally the Federal University of Agriculture, is a federal university in Umudike, Abia State, Nigeria established as a specialized University by a Federal Government of Nigeria Decree No 48 of November 1992. It began formal activities in May 1993 with the appointment of the first Council and Vice-Chancellor Professor Placid C. Njoku on 27 May 1993, while other key officials of the University were appointed later.The first set of students were admitted into the institution during the 1993/94 academic year with a student population of 82.The nickname "Umudykes" or "U'dykers" refers to students, alumni, and sports teams of Michael Okpara University of Agriculture. Wikipedia.

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Ezeigbo I.I.,Michael Okpara University of Agriculture
African journal of traditional, complementary, and alternative medicines : AJTCAM / African Networks on Ethnomedicines | Year: 2012

The effect of methanolic extract of Hymenocardia acida leaves on diabetes and associated lipidemia were investigated on experimentally-induced diabetic rats. The extract did not demonstrate any acutely toxic effect in rats within the dose range (250 mg/kg - 2000 mg/kg) employed in the study; hence it was well tolerated by the rats. In all experiments, the anti-diabetic effects were dose-dependent and comparable to that of glibenclamide (2 mg/kg) standard. At a dose of 500 mg/kg, lipid profile markers such as the serum total cholesterol (TC) levels, LDL-C, triglycerides and HDL-C were significantly lower (p <0.05) than those of both the treated and untreated controls.

Egbuonu A.C.C.,Michael Okpara University of Agriculture
Research Journal of Environmental Toxicology | Year: 2015

The proximate and functional properties of the watermelon (Citrullus lanatus) rind and seed flour were investigated, using standard methods. The proximate compositions (%) for the rind and seed, respectively were moisture (5.12±0.01, 3.81±0.00), dry matter (94.88±0.01, 96.20±0.00), lipid/fat (1.05±0.01, 41.84±0.04), crude protein (7.04±0.00, 21.46±0.04), carbohydrate (80.75±0.04, 28.05±0.06), crude ash (3.07±0.00, 2.48±0.01) and crude fibre (2.98±0.00, 2.37±0.00). The energy value (360.59*0.01, 574.58±0.30 kcal), total sugar (0.47±0.01, 3.23±0.02%) and total soluble sugar (1.42±0.01, 4.87±0.00%), respectively for the rind and seed were lower in the rind than in the seed sample. The functional properties (%) for the rind and seed, respectively viz. water absorption capacity (7.13±00, 116.3±00), oil absorption capacity (1.65±00, 123.5±00), foaming capacity (5.65±00, 21.5±00), foaming stability (20.75±00, 60.5±00) and emulsion stability (0.28±00) were higher in the seed sample. The difference in value of the parameters for the samples, aside emulsion stability, ash and fibre, were significant (p<0.05). The results imply that the flour of watermelon (Citrullus lanatus) seed, followed by that of the rind, has nutrient, energy, storage and industrial potentials which could increase their utilization thereby preventing a possible adverse environmental effect. © 2015 Academic Journals Inc.

Ejike C.E.C.C.,Michael Okpara University of Agriculture | Yin F.Z.,The First Hospital of Qinhuangdao
Journal of Tropical Pediatrics | Year: 2013

The diagnostic accuracy of blood-pressure-toheight-ratios (BPHRs) in 716 Nigerian children was studied, using standard protocols. Systolic BPHR (SBPHR) and diastolic BPHR (DBPHR) had diagnostic accuracies ranging from 0.934 to 1.000, irrespective of sex and age. Optimal thresholds of SBPHR/DBPHR are provided, and their sensitivities and specificities all exceeded 80%. BPHR is a simple, sensitive and specific tool for the diagnosis of hypertension in this population. © The Author [2012]. Published by Oxford University Press. All rights reserved.

Nwabueze T.U.,Michael Okpara University of Agriculture
International Journal of Food Science and Technology | Year: 2010

Techniques involving choosing process combinations for optimisation without due consideration for relevant experimental designs is scientifically unreliable and irreproducible. Mathematical modelling, of which response surface methodology (RSM) is one, provides a precise map leading to successful optimisation. This paper identified key process variables, building the model and searching the solution through multivariate regression analysis, interpretation of resulting polynomial equations and response surface/contour plots as basic steps in adapting the central composite design to achieve process optimisation. It also gave information on appropriate RSM software packages and choice of order in RSM model and data economy in reducing the factorial experiments from large number parameter combinations to a far less number without losing any information including quadratic and interaction (if present) effects. It is expected that this paper will afford many food scientists and researchers the opportunity for adapting RSM as a mathematical model for achieving bioprocess optimisation in food systems. © 2010 The Author. Journal compilation © 2010 Institute of Food Science and Technology.

Ejike C.E.C.C.,Michael Okpara University of Agriculture
International Journal of STD and AIDS | Year: 2011

The aetiology of chronic prostatitis is poorly understood. A cross-sectional study of a population of male undergraduates in Nigeria, using a questionnaire containing the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) and some other relevant sex-related questions, was conducted. A total of 14.9% of the population had chronic prostatitis symptoms (CPSs) defined as a pain score of four or more on the NIH-CPSI pain subscale. Approximately 26 or 12%of the population had at least one, or ≥ 2 location(s) of pain, respectively. The presence of CPS was found to correlate with a self-reported history of sexually transmitted infection (STI) (r = +0.237; P < 0.05) and 73% of those with a self-reported history of STI had CPS. Both voiding scores and quality-of-life scores were significantly higher in subjects with CPS, compared with those without CPS. Self-reported history of STI may be an important aetiological factor for chronic prostatitis/chronic pelvic pain symptoms.

Ezeigbo I.I.,Michael Okpara University of Agriculture
International Journal of Diabetes in Developing Countries | Year: 2010

Background: The effect of the methanolic leaf extracts of Icacina trichantha on blood glucose levels in alloxan-induced diabetes in mice was investigated. Methods: Hyperglycemia was induced by the injection of 150 mg/kg (i.p.) of alloxan monohydrate freshly dissolved in distilled water. Three doses (200, 300, and 450 mg/kg) per os, of the extracts were administered in the study. The activity was compared with reference standard glibenclamide (2 mg/kg, p.o.) and negative control. Results: Treatment of alloxan-induced diabetic mice with the crude extract of I. trichantha leaves brought down the raised blood glucose levels significantly (P < 0.01) in a dose-dependent manner. Conclusion: The result suggests that I. trichantha possesses antidiabetic property.

Mbaebie B.O.,Michael Okpara University of Agriculture | Edeoga H.O.,Michael Okpara University of Agriculture | Afolayan A.J.,University Of Fort Hare
Asian Pacific Journal of Tropical Biomedicine | Year: 2012

Objective: To evaluate the phytochemical constituents and antioxidant activities of aqueous extract of Schotia latifolia (S. latifolia) bark locally used for the treatment of oxidative stress-induced ailments in South Africa. Methods: The antioxidant and free radical scavenging activity of aqueous extract of the plant was assessed against 1,1 -diphenyl-2-picrylhydrazyl (DPPH), nitric oxide (NO), 2,2'-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) and the ferric reducing agent. Total phenolics, flavonoids, flavonols and proanthocyanidins were also determined to assess their corresponding effect on the antioxidant activity of this plant. Results: The activities of plant extract against DPPH, ABTS and NO radicals were concentration dependent with IC 50 value of 0.06, 0.05 and 0.05 mg/mL, respectively. The reducing power of the extract was greater than that of butylated hydroxyl toluene (BHT) and ascorbic acid which were used as standard drugs in a concentration dependent manner. The total phenolics content of the aqueous bark extract was (193.33+0.03 TE/g), followed by flavonoids (72.70+0.01 QE/g), proanthocyanidins (48.76+0.00 CE/g) and flavonols (47.76+0.21 QE/g). Phytochemical analysis revealed the presence of percentage tannin (11.40+0.02), alkaloid (9.80+0.01), steroids (18.20+0.01), glycosides (29.80+0.01) and saponins (6.80+0.00). The results exhibited a positive linear correlation between these polyphenols and the free radical scavenging activities. Conclusions: Our findings provide evidence that the crude aqueous extract of S. latifolia is a potential source of natural antioxidants and this justifies its uses in folkloric medicines.

Stand-alone solar photovoltaic power systems are natural options for application in the electrification of remote areas which are outside the grid connected electricity supply systems. They represent a vast and varied range of possibilities. A standard and durable stand-alone photovoltaic system with more than 20 years life expectancy for handling household appliances in remote residential locations has been designed. This was necessitated by the fact that most rural villages are not connected to the national grid supply which has been very epileptic, unsteady and unpredicted even when available. Also, the technical overview of this system and the impact of solar irradiance on the performance of photovoltaic cells are presented. Further, the system's design including the general load evaluation and the ampere-hour method of sizing the system and its balance-of-system components are adopted and consolidated. From the design performance, the calculated ampere-hour load was estimated at 1388.88 AH/day with a system design current of 374.92 Amps and a peak current of 232.74 Amps, while the corrected ampere-hour load was 1574.66 AH/day, respectively. These, have the capacity of derating the current at 416.58 Amps utilizing a total of 640 modules and 144 deep-charge solar photovoltaic batteries. © 2011 Praise Worthy Prize S.r.l. - All rights reserved.

Ejike C.E.,Michael Okpara University of Agriculture | Ijeh I.I.,Michael Okpara University of Agriculture
International Archives of Medicine | Year: 2012

Background: Overweight/obesity is a growing global public health concern. The variations in the prevalence of overweight/obesity, defined by Body Mass Index (BMI), Waist Circumference (WC), Waist-to-Height Ratio (WHtR), Waist-to-Hip Ratio (WHpR) and Bioelectrical Impedance Analysis (BIA), were studied and a prediction equation for % body fat (%BF) developed. Methods. A total of 1584 subjects (56.4% males) were recruited for the study. Data on age, gender, height, weight, hip circumference and WC were collected from the subjects using standard protocols. BMI, WHtR and WHpR were derived using standard equations. %BF was measured using a BIA device (Omron BF-400). Appropriate statistical tools were used for the data analysis. Results: The prevalence of overweight/obesity in the population was 28.4% (36.3% for males; 22.6% for females) (BIA); 20.7% (17.5% for males; 24.8% for females) (BMI); 7.5% (1.3% for males; 16.1% for females) (WC); 2.9% (4.3% for males; 1.2% for females) (WHpR); and 15.4% (14.8% for males; 16.2% females) (WHtR). Taking BIA as the reference point, WC misclassified overweight/obesity the most for males (35%), while for the females, WHpR misclassified both disorders the most (21.4%). Correlation studies showed that only BMI correlated significantly, albeit weakly, with %BF among the males, whereas all the anthropometric measures, but WHpR correlated significantly with % body fat in females. Two prediction equations for %BF were generated, and %BF predicted with the two equations correlated significantly (P<0.001) with that measured by BIA. Conclusion: The prevalence of overweight/obesity in this population vary widely depending on the definition used. The developed prediction equations could be useful in resource-poor settings, but require validation. © 2012 Ejike and Ijeh; licensee BioMed Central Ltd.

Ejike C.E.C.C.,Michael Okpara University of Agriculture
Italian Journal of Pediatrics | Year: 2011

Background: The age-, gender-, and height-percentile requirements of the 'gold-standard' for the diagnosis of (pre)hypertension in adolescents make it time-consuming for clinicians and difficult-to-use by non-professionals. Simplified diagnostic tools are therefore needed. The use of blood pressure-to-height ratio (BPHR) - systolic BPHR (SBPHR) and diastolic BPHR (DBPHR) - has been reported in Han adolescents, but it requires validation in other racial groups. The diagnostic accuracy of SBPHR and DBPHR in a population of 1,173 Nigerian adolescents aged 11-17 years, was therefore studied. Methods. Blood pressures were measured using standard procedures and (pre)hypertension were defined according to international recommendations. ROC curve analyses were used to assess the diagnostic accuracy of BPHR in defining (pre)hypertension in this population. Sex-specific threshold values for SBPHR and DBPHR were determined, and thereafter used to define (pre)hypertension. The sensitivity/specificity of this method was determined. Results: The accuracies of SBPHR and DBPHR in diagnosing (pre)hypertension, in both sexes, was >92%. The optimal thresholds for diagnosing prehypertension were 0.72/0.46 in boys and 0.73/0.48 in girls; while for hypertension, they were 0.75/0.51 in boys and 0.77/0.50 in girls. The sensitivity and specificity of this method were >96%. Conclusions: The use of BPHR is valid, simple and accurate in this population. Race-specific thresholds are however needed. © 2011 Ejike; licensee BioMed Central Ltd.

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