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Fan Y.,Central Hospital of Mianyang
Zhonghua nan ke xue = National journal of andrology | Year: 2012

Radical prostatectomy (RP) is preferred for many patients with clinically localized prostate cancer. Despite the introduction of the nerve sparing technique and progressive modifications on RP, postoperative preservation of penile erectile function remains a challenge to urologists. Earlier initiation of penile rehabilitation can significantly improve the patient's quality of life affected by erectile dysfunction (ED) following RP. Tadalafil, a long-acting PDE5 inhibitor with a unique clinical profile, has proved effective in penile rehabilitation in the treatment of RP-associated ED in both clinical trails and animal models. This article reviews current strategies for the management of ED after RP and evaluates the efficacy and safety of tadalafil in post-RP penile rehabilitation. Source


Shi B.,Central Hospital of Mianyang
Zhongguo gu shang = China journal of orthopaedics and traumatology | Year: 2013

To evaluate the emergency therapeutic effects of intertrochanteric fractures in elderly patients. A retrospective study was designed. From March 2006 to March 2012, 254 patients with intertrochanteric fractures treated in Mianyang Central Hospital were reviewed. The patients with old fractures, pathological fractures, multiple trauma and severe medical comorbidities of admission were excluded. So 127 patients with intertrochanteric fractures over 70 years old were included in the study, including 38 males and 89 females, and the patients were divided into 2 groups: 56 patients underwent emergency operation within 24 h after injury (emergency operation group), 71 patients underwent an operation more than 24 h after injury (not emergency operation group). The following data were collected retrospectively for all patients: (1) in-hospitalcomplications, including electrolyte disturbance, hidden blood loss, delirium, deep vein thrombosis, upper gastrointestinal hemorrhage, pulmonary infection, urinary tract infection, cardiovascular and cerebrovascular disease, bedsore. (2) prognosis, ineluding in-hospital mortality, mortality in the 1st year, length of hospital stay, fracture healing times, hip score. Comparisons between the two groups were made using SPSS13.0. The quantitative data and categorical data were analyzed by t test and chi2 test, respectively. The main medical complications in emergency operation group were hidden blood loss, delirium, pulmonary infection, electrolyte disturbances, urinary tract infections, and in not emergency operation group followed respectively by hidden blood loss, lung infection, electrolyte disturbances, delirium, and pulmonary infection. In-hospital mortality was zero, and 1 in the 1st year in emergency operation group; while in not emergency operation group were 4 and 7 respectively. An average length of hospital stay with (9 +/- 3) d in emergency operation group was lower than (17 +/- 8) d in not emergency operation group. Fracture healing time was (12 +/- 2) weeks in both groups. The significant variables with P < 0.05 between the two groups were electrolyte disorders, delirium, deep venous thrombosis, pulmonary infection, urinary tract infection, bedsore, in-hospital mortality, mortality in the 1st year, and length of hospital stay. The differences of hidden blood loss, upper gastrointestinal hemorrhage, cardiovascular and cerebrovascular disease, fracture healing times, hip score between the two groups had no significant differences (P > 0.05). The emergency surgery (within 24 h after injury) reduces length of hospital stay, and may also reduce complications and mortality. Source


Xu J.,University of Sichuan | You C.,University of Sichuan | Zhou L.,University of Sichuan | Wu B.,Province People Hospital | And 6 more authors.
World Neurosurgery | Year: 2011

Objective: To present an overview of mortality, disability, and depression among patients with head injuries admitted to multiple center hospitals after the 2008 Wenchuan earthquake in China. Methods: A retrospective analysis was done of the medical records of earthquake victims with head traumas admitted to three different area hospitals; analysis included 18 months of follow-up. Demographic data, causes of injury, diagnosis, clinical classification, treatment, and prognosis were reviewed. Results: This analysis included 1299 victims with craniocerebral injuries admitted to eight hospitals in or near the disaster zone. The victims were divided into three main groups. Group A comprised 68 victims treated in the local hospital; all 68 (100%) were hospitalized during the 24 hours after the earthquake, and 38 (55.88%) victims died 18 months later. Group B comprised 600 victims treated in regional hospitals; 264 (44%) were admitted within 72 hours after the earthquake, and 109 (18.17%) died. Group C comprised 631 victims transported to territory hospitals; 39 (6.18%) were dead at 18 months. Among survivors, 409 (31.48%) victims sustained a disability, and 879 (80.35%) have depression. Conclusions: In the first 72 hours after this major earthquake, the local and regional hospital neurosurgery departments were flooded with numerous victims with craniocerebral injuries. Most of these patients died or were disabled. The territory hospitals with expert neurosurgeons and advanced equipment did not effectively contribute to successful treatment of victims. The mobile hospital played an important role in initial triage and treatment. Peer-Review Article © 2011 Elsevier Inc. All Rights Reserved. Source


Kuang P.,University of Sichuan | Liu T.,University of Sichuan | Pan L.,University of Sichuan | Zhu H.,University of Sichuan | And 19 more authors.
Leukemia and Lymphoma | Year: 2016

We report the clinical results of sustainedly integrating imatinib and interferon-α into maintenance therapy in the patients ineligible for allogeneic hematopoietic stem cell transplantation (allo-HSCT). Maintenance therapy lasted for 5 years with imatinib 400 mg daily, interferon-α 3 million units, 2∼3 doses per week, and chemotherapy including vindesine and dexamethasone scheduled monthly in first year, once every 2 months in second year, and once every 3 months in third year. The chemotherapy was discontinued after 3 years and the imatinib and interferon-α continued for another 2 years. For 41 patients without allo-HSCT with a median follow-up of 32 months, the 3-year DFS and OS were 42.7  ± 8.6% and 57.9  ± 8.4%, respectively. Our study suggests that sustaining maintenance with low-dose chemotherapy, imatinib and interferon-α improved survival of adult Philadelphia-positive acute lymphoblastic leukemia (Ph + ALL) patients ineligible for allo-HSCT, and even provided an opportunity for cure. BCR/ABL persistent negativity at 6 and 9 months may have benefit to choose suitable patients for the imatinib/interferon-α maintenance strategy. © 2016 Taylor & Francis Source


Fan Y.,Central Hospital of Mianyang
Zhonghua nan ke xue = National journal of andrology | Year: 2011

Erectile dysfunction (ED) has been widely accepted as a typical psychosomatic disorder. Psychosocial factors play a critical role in the pathogenesis of ED. In turn, ED also has a substantial effect on psychosocial health and interpersonal relationship between ED patients and their partners. It is rational that psychosomatic treatment is the key to the treatment of ED, including both psychosexual counseling and appropriate medical intervention. The evolution of human health mode has revolutionized the goal of ED management, focusing on the successful restoration of natural harmonious sexual life and intimate relationship between the patients and their partners, rather than the physiological outcomes of erection hardness and duration of maintenance. Tadalafil, a novel phosphodiesterase type 5 (PDE5) inhibitory agent effective for ED of any etiology and severity, can significantly decrease the time concerns of the patients, greatly satisfy the treatment expectations of both the patients and their partners, restore the normal and natural sexual life, and improve the patients' psychosexual health. Source

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