News Article | November 30, 2016
MIAMI, Nov. 30, 2016 /PRNewswire/ -- Mi9 Retail congratulates Tea Collection, a children's fashion retailer, on achieving record online sales during the annual Black Friday/Cyber Monday promotional period. Tea Collection is an Mi9 Retail customer that uses the Mi9 e-Commerce platform to...
Ladd B.,MI |
Ladd B.,Harvard University |
Ackroyd J.J.,MI |
Hicks J.K.,MI |
And 4 more authors.
DNA Repair | Year: 2013
The nucleoside analog ganciclovir (GCV) elicits cytotoxicity in tumor cells via a novel mechanism in which drug incorporation into DNA produces minimal disruption of replication, but numerous DNA double strand breaks occur during the second S-phase after drug exposure. We propose that homologous recombination (HR), a major repair pathway for DNA double strand breaks, can prevent GCV-induced DNA damage, and that inhibition of HR will enhance cytotoxicity with GCV. Survival after GCV treatment in cells expressing a herpes simplex virus thymidine kinase was strongly dependent on HR (>14-fold decrease in IC50 in HR-deficient vs. HR-proficient CHO cells). In a homologous recombination reporter assay, the histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA; vorinostat), decreased HR repair events up to 85%. SAHA plus GCV produced synergistic cytotoxicity in U251tk human glioblastoma cells. Elucidation of the synergistic mechanism demonstrated that SAHA produced a concentration-dependent decrease in the HR proteins Rad51 and CtIP. GCV alone produced numerous Rad51 foci, demonstrating activation of HR. However, the addition of SAHA blocked GCV-induced Rad51 foci formation completely and increased γH2AX, a marker of DNA double strand breaks. SAHA plus GCV also produced synergistic cytotoxicity in HR-proficient CHO cells, but the combination was antagonistic or additive in HR-deficient CHO cells. Collectively, these data demonstrate that HR promotes survival with GCV and compromise of HR by SAHA results in synergistic cytotoxicity, revealing a new mechanism for enhancing anticancer activity with GCV. © 2013 Elsevier B.V.
News Article | December 6, 2016
MIAMI, Dec. 6, 2016 /PRNewswire/ -- Mi9 Retail, a premier provider of omni-channel retail solutions, is pleased to announce that it has been ranked number one among software providers for Tier One retailers, and has been ranked number two overall on the 2016 RIS Software LeaderBoard....
PubMed | M.I. ., VU University Amsterdam and Mount Sinai School of Medicine
Type: Journal Article | Journal: AJNR. American journal of neuroradiology | Year: 2015
At 7T MR imaging, T2*-weighted gradient echo has been shown to provide high-resolution anatomic images of gray matter lesions. However, few studies have verified T2*WI lesions histopathologically or compared them with more standard techniques at ultra-high-field strength. This study aimed to determine the sensitivity of T2WI and T2*WI sequences for detecting cortical GM lesions in MS.At 7T, 2D multiecho spin-echo T2WI and 3D gradient-echo T2*WI were acquired from 27 formalin-fixed coronal hemispheric brain sections of 15 patients and 4 healthy controls. Proteolipid-stained tissue sections (8 m) were matched to the corresponding MR images, and lesions were manually scored on both MR imaging sequences (blinded to histopathology) and tissue sections (blinded to MR imaging). The sensitivity of MR imaging sequences for GM lesion types and white matter lesions was calculated. An unblinded retrospective scoring was also performed.If all cortical GM lesions were taken into account, the T2WI sequence detected slightly more lesions than the T2*WI sequence: 28% and 16%, respectively (P = .054). This difference disappeared when only intracortical lesions were considered. When histopathologic information (type, location) was revealed to the reader, the sensitivity went up to 84% (T2WI) and 85% (T2*WI) (not significant). Furthermore, the false-positive rate was 8.6% for the T2WI and 10.5% for the T2*WI sequence.There is no strong advantage of the T2*WI sequence compared with a conventional T2WI sequence in the detection of cortical lesions at 7T. Retrospectively, a high percentage of lesions could be detected with both sequences. However, many lesions are still missed prospectively. This could possibly be minimized with better a priori observer training.
Nelson J.,Harvard University |
Price E.,MI |
Wootters M.,University of Michigan
Proceedings of the Annual ACM-SIAM Symposium on Discrete Algorithms | Year: 2014
In this paper, we present novel constructions of matrices with the restricted isometry property (RIP) that support fast matrix-vector multiplication. Our guarantees are the best known, and can also be used to obtain the best known guarantees for fast Johnson Lindenstrauss transforms. In compressed sensing, the restricted isometry property is a sufficient condition for the efficient reconstruction of a nearly k-sparse vector x ∈ C d from m linear measurements Φx. It is desirable for to to be small, and further it is desirable for Φ to support fast matrix- vector multiplication. Among other applications, fast multiplication improves the runtime of iterative recovery algorithms which repeatedly multiply by Φ or Φ*. The main contribution of this work is a novel randomized construction of RIP matrices Φ ∈ Cm×d, preserving the ℓ2 norms of all k-sparse vectors with distortion 1 + ε, where the matrix-vector multiply Φx can be computed in nearly linear time. The number of rows m is on the order of ε-2klog d log2(k log d), an improvement on previous analyses by a logarithmic factor. Our construction, together with a connection between RIP matrices and the Johnson-Lindenstrauss lemma in [Krahmer-Ward, SIAM. J. Math. Anal. 2011], also implies fast Johnson-Lindenstrauss embeddings with asymptotically fewer rows than previously known. Our construction is actually a recipe for improving any existing family of RIP matrices. Briefly, we apply an appropriate sparse hash matrix with sign flips to any suitable family of RIP matrices. We show that the embedding properties of the original family are maintained, while at the same time improving the number of rows. The main tool in our analysis is a recent bound for the supremum of certain types of Rademacher chaos processes in [Krahmer-Mendelson- Rauhut, Comm. Pure Appl. Math, to appear]. Copyright © 2014 by the Society for Industrial and Applied Mathematics.
PubMed | University of Michigan and M.I.
Type: Journal Article | Journal: AJNR. American journal of neuroradiology | Year: 2014
Despite recent improvements in perinatal care, the incidence of neonatal brachial plexus palsy remains relatively common. CT myelography is currently considered to be the optimal imaging technique for evaluating nerve root integrity. Recent improvements in MR imaging techniques have made it an attractive alternative to evaluate nerve root avulsions (preganglionic injuries). We aim to demonstrate utility of MR imaging in the evaluation of normal and avulsed spinal nerve roots.All study patients with clinically diagnosed neonatal brachial plexus palsy underwent MR imaging by use of a high-resolution, heavily T2-weighted (driven equilibrium) sequence. MR imaging findings were reviewed for presence of nerve root avulsion from C5-T1 and for presence of pseudomeningocele. The intraoperative findings were reviewed and compared with the preoperative MR imaging findings.Thirteen patients (9 male, 4 female) underwent MR imaging; 6 patients underwent nerve reconstruction surgery, during which a total of 19 nerve roots were evaluated. Eight avulsions were noted at surgery and in the remainder, the nerve injury was more distal (rupture/postganglionic injury). Six of the 8 nerve root avulsions identified at surgery were at C5-6 level, whereas 1 nerve root avulsion was identified at C7 and C8 levels, respectively. The overall sensitivity and specificity of MR imaging for nerve root avulsions was 75% and 82%, respectively.Our preliminary results demonstrate that high-resolution MR imaging offers an excellent alternative to CT myelography for the evaluation of neonatal brachial plexus palsy with similar sensitivity compared with CT myelography.
News Article | February 20, 2017
MIAMI, Feb. 20, 2017 /PRNewswire/ -- Mi9 Retail is pleased to announce that Tori Richard Ltd., a Hawaii-based manufacturer of men's and women's resort wear, has gone live on Mi9 e-Commerce and Order Management as part of its omni-channel expansion strategy. Tori Richard was founded...
IEEE Pulse | Year: 2014
The human body is a microbe's playground: interspersed among the 37 trillion cells of the human body  are at least ten times as many bacteria, fungi, viruses, and archaea. That amounts to 100 times as many microbial genes as human genes. ©2014IEEE.
PubMed | M.I.
Type: Journal Article | Journal: International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists | Year: 2015
B7-H3 is a transmembrane protein and a member of the B7 family of immune regulatory ligands. It exerts both inhibitory and stimulatory effects on the activation of T cells. We investigated the expression of B7-H3 in invasive squamous cell carcinoma (ISCC) of the uterine cervix by immunohistochemistry, and aimed to determine whether expression of this factor is involved in the progression of the morphologic spectrum from normal cervical epithelia to cervical intraepithelial neoplasia and cervical ISCC. In addition, we sought to examine the relation of B7-H3 to the abundance of tumor-infiltrating and tumor-associated CD8(+) lymphocytes and to the evidence of phosphohistone H3, which is a core histone protein detected during mitosis. B7-H3 immunostaining was scored with regard to quantity and intensity of positively stained cells, and was noted in membranous and cytoplasmic patterns in epithelial cells and on endothelia of stromal blood vessels. Compared with those in intraepithelial neoplasias, immunoscores were significantly increased in ISCC (P<0.0001 for epithelial and endothelial expression, respectively). High scoring was associated with International Federation of Gynecology and Obstetrics stages IB and higher. Immunoscores of epithelial and endothelial B7-H3 expression were correlated significantly (P=0.0358). Epithelial and endothelial expression of B7-H3 was inversely related with CD8(+) tumor-infiltrating lymphocyte (P<0.0001). Moderate/strong B7-H3 epithelial as well as endothelial expression was mutually increased with intermediate/strong phosphohistone H3 scores (P=0.0396 and P=0.0483, respectively). There was no statistical relation with survival; however, no patient with negative scoring died of her tumor. Our results indicate that B7-H3 expression in cervical ISCC may play an important role in overcoming CD8(+) T-cell immunoregulation to acquire aggressive growth.
News Article | November 29, 2016
MIAMI, Nov. 29, 2016 /PRNewswire/ -- Mi9 Retail is pleased to announce that Peter Sheppard Footwear, an internationally recognized women's footwear retailer based in Australia, has selected the Mi9 Retail omni-channel suite to run its business. Peter Sheppard Footwear will deploy the host...