Entity

Time filter

Source Type

Nashik, India

Patil R.A.,MGVs Pharmacy College | Kasture S.B.,Pinnacle Biomedical Research Institute
Natural Product Research | Year: 2012

In this study, the neuroprotective potential and in vivo antioxidant status of extract of roots and rhizomes of Rubia cordifolia L (MERC) in reserpine-induced orofacial dyskinesia was studied. Reserpine (1 mg/kg, s.c.) on day 1, 3 and 5 was used to induce orofacial dyskinesia. At the end of treatment schedule, MERC significantly inhibited reserpine-induced vacuous chewing movements, tongue protrusions, orofacial bursts, catalepsy. MERC significantly increased locomotion and rearing in open field test. MERC exhibited significant elevation in the levels of superoxide dismutase, catalase, glutathione reductase and inhibition of lipid peroxidation in forebrain region, compared with the reserpine treated group. It significantly elevated dopamine levels in the forebrain region. GCMS revealed the presence of anthraquinones, having strong antioxidant activity. It is concluded that oxidative stress might play an important role in reserpine-induced abnormal oral movements and MERC significantly protected animals against reserpine-induced orofacial dyskinesia and has great potential in treatment of neuroleptic induced orofacial dyskinesia. © 2012 Taylor & Francis Group, LLC. Source


Chittal M.U.,MGVs Pharmacy College
International Journal of Pharmaceutical Sciences Review and Research | Year: 2011

Retinitis pigmentosa (RP) is a group of genetic eye conditions that leads to incurable blindness. It further results in tunnel vision, people with Retinitis pigmentosa are not legally blind until their 40s or 50s, while in some cases patients may become blind due to RP as early as in their childhood. However, patients who have gone blind because of retinitis pigmentosa are a step closer to perhaps one day regaining some of their sight with the news that the United States FDA has approved a study to evaluate an artificial retina. Researchers at the USC Doheny Eye Institute have developed the technology that hopefully will help patients with Retinitis pigmentosa and macular degeneration regains some vision using an implanted artificial retina. The Food and Drug Administration approved an Investigational Device Exemption to conduct a clinical study of the new device - dubbed the Argus II Bionic Retinal System. Apart from these there have been breakthroughs in development of bionic eye in number of institutions throughout the world. This review paper deals the technology and the working of the device which would help in eradicating blindness in the near future. Source


Gharate M.,MGVs Pharmacy College | Kasture V.,Pinnacle Biomedical Institute of Research and Education
Oriental Pharmacy and Experimental Medicine | Year: 2013

Punarnavasava, an Ayurvedic liquid dosage form containing self generated alcohol is commonly used to treat inflammatory conditions and edema. In the present study, we evaluated anti-inflammatory, analgesic, antipyretic, and antiulcer activity of three different brands of Punarnavasava. The formulation significantly inhibited carrageenan-induced rat paw edema, cotton pellet-induced granuloma, formalin-induced paw licking, yeast induced hyperpyrexia and pyloric ligated ulcers in rats. The study concludes that Punarnavasava has anti-inflammatory, central as well as peripheral antinociceptive, antipyretic and antiulcer activity and thus justifies its use in inflammatory conditions. © 2012 Institute of Oriental Medicine, Kyung Hee University. Source


Mohan M.,MGVs Pharmacy College | Kamble S.,MGVs Pharmacy College | Gadhi P.,Computerised Laboratory | Kasture S.,Pinnacle Biomedical Research Institute
Food and Chemical Toxicology | Year: 2010

Nephrotoxicity is one of the important side effects of anthracycline antibiotics. The aim of the study was to determine the protective effect of Solanum torvum on doxorubicin-induced nephrotoxicity in rats using biochemical and histopathological approaches. Oxidative stress is the main factor in doxorubicin (DOX) induced nephrotoxicity. Wistar rats received either DOX (67.75 mg/kg, i.v, 2 days before sacrifice) or S. torvum (100 mg/kg and 300 mg/kg, p.o.) prior to DOX treatment or S. torvum (100 mg/kg and 300 mg/kg, p.o.) extract alone for 4 weeks. Nephrotoxicity was assessed by measuring the abnormal levels of serum creatinine and blood urea nitrogen (BUN). The anti-oxidant defence enzymes superoxide dismutase (SOD) and catalase (CAT) of kidney tissue were also measured at the end of the treatment schedule. Treatment with S. torvum (100 mg/kg and 300 mg/kg) significantly (p < 0.05) decreased the levels of creatinine and BUN and significantly (p < 0.05) increased the anti-oxidant defence enzyme levels of SOD and CAT. Histopathological changes showed that DOX caused significant structural damages to kidneys like tubular necrosis, renal lesions and glomerular congestion which was reversed with S. torvum. The results suggest that S. torvum has the potential in preventing the nephrotoxicity induced by doxorubicin. © 2009 Elsevier Ltd. All rights reserved. Source


Patil R.A.,MGVs Pharmacy College | Hiray Y.A.,MGVs Pharmacy College | Kasture S.B.,Pinnacle Biomedical Research Institute
Indian Journal of Pharmacology | Year: 2012

Context: Reserpine-induced orofacial dyskinesia is an animal model of tardive dyskinesia which may be associated with neurodegeneration and free radical damage. Aim: The aim was to assess the neuroprotective potential and in vivo antioxidant status of alcoholic extract of roots and rhizomes of Nardostachys jatamansi (ANJ) and its triterpenes (TNJ) in reserpine-induced orofacial dyskinesia. Materials and Methods: In the present study, repeated treatment with reserpine (1.0 mg/kg) on each other day for a period of 5 days (days 1, 3, and 5) significantly induced vacuous chewing movements (VCMs) and tongue protrusions (TPs) in rats. The effect on reserpine-induced catalepsy was also studied. The effect of ANJ and TNJ on levels of superoxide dismutase (SOD), catalase (CAT), and glutathione reductase (GSH) and inhibition of lipid peroxidation (LPO) in the forebrain region was assessed. Statistical Analysis: All observations were expressed as mean ± SEM. Statistical analysis was performed by the one-way ANOVA followed by Dunnett′s test. P<0.05 was regarded as statistically significant. Results: At the end of the treatment schedule, ANJ and TNJ significantly inhibited reserpine-induced VCM, TP, and catalepsy, and significantly increased the locomotion and rearing in the open-field test. Treatment with ANJ and TNJ exhibited significant elevation in the levels of superoxide dismutase (SOD), catalase (CAT), and glutathione reductase (GSH) and inhibition of lipid peroxidation (LPO) in forebrain region compared to the reserpine treated group. Conclusions: The study concludes that ANJ and TNJ significantly protected animals against reserpine-induced orofacial dyskinesia as well as catalepsy suggesting its potential value in the treatment of neuroleptic-induced orofacial dyskinesia and Parkinson′s disease. Source

Discover hidden collaborations