MGVs Pharmacy College

Nashik, India

MGVs Pharmacy College

Nashik, India
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Rote A.R.,MGVs Pharmacy College | Bari P.D.,MGVs Pharmacy College
Indian Journal of Pharmaceutical Sciences | Year: 2010

A simultaneous determination of olmesartan medoxomil and hydrochlorothiazide by absorption ratio spectrophotometric method has been developed in combined tablet dosage form. The method is based on measurements of absorbance at isoabsoptive point. The Beer′s law obeys in the range of 10-30 μg/ml for both olmesartan medoxomil and hydrochlorothiazide respectively. The proposed method was validated by performing recovery study and statistically.

Gaikwad S.S.,MGVs Pharmacy College
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2013

Objective: Pantoprazole undergoes hepatic first pass metabolism, hence it shows poor bioavailability. Stability of Pantoprazole in human saliva was improved using magnesium oxide due to its strong waterproofing effect. In present study attempt has been done to improve the bioavailability by formulating mucoadhesive buccal tablet as well as to improve stability of tablet in human saliva. Methods: Nine formulations were developed with varying concentrations of polymers like Sodium alginate and HPMC. To determine the effect of selected excipients on the release of pantoprazole a full factorial design 32 was setup. Results: The formulations were evaluated for weight variation, hardness, surface pH, drug content uniformity, swelling index, and bioadhesive strength and in-vitro drug dissolution study. FTIR studies showed no evidence of interactions between drug and excipients. The maximum in-vitro drug release profile was achieved with the formulation F6 which contains the drug, Sodium alginate and HPMC K4M in the (20/17/8) mg respectively. The surface pH, bioadhesive strength and drug content of formulation F6 was found to be 7.1, 27.9, and 98.0 % respectively. The formulation F6 exhibited sustained drug release i.e. 98.009 % in 6 h and 80.12 % drug diffusion in 8 h through the sheep buccal mucosa. The in vitro release kinetics studies reveal that formulations fit well with zero order kinetics and mechanism of drug release is non-Fickian diffusion. Conclusion: It is concluded that magnesium oxide stabilize the pantoprazole buccal tablet in human saliva for at least 6 h and also improves oral bioavailability.

Pawar A.Y.,MGVs Pharmacy College | Sonawane D.D.,MGVs Pharmacy College | Erande K.B.,MGVs Pharmacy College | Derle D.V.,P.A. College
Drug Invention Today | Year: 2013

New advances in different technologies have made the previously unused terahertz frequency band accessible for imaging systems. The 'terahertz gap' has a frequency ranges from ~0.3THz to ~10THz in the electromagnetic spectrum which in between microwave and infrared. The terahertz radiations are invisible to naked eye & in comparison with X-ray they are intrinsically safe, non-destructive and non-invasive. This is such a new field that researchers around the world race to build the first practical system. It resolves many of the questions left unanswered by complementary techniques, such as optical imaging, Raman and infrared. Terahertz spectroscopy has number of applications run from detecting defects in tablet coating, product inspection (industry), spectroscopy (chemistry, astronomy), material characterization (physics), weapons concealed under clothing (airports), detection of cancer and caries. In the pharmaceutical industries it enables nondestructive, internal, chemical analysis of tablets, capsules and other dosage forms. This paper tries therefore not only to provide a brief overview over the imaging technology, but also over the whole range of current systems and research in terahertz technology. © 2013 JPR Solutions. Published by Reed Elsevier India Pvt. Ltd.

Gaikwad M.,Mgvs Pharmacy College | Kale S.,Mgvs Pharmacy College
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2011

The present study was designed to study the sunscreen activity of herbal formulation. There is no evidence regarding the sun protection factor studies on seed oil of Moringa oleifera L, (Moringaceae). This study investigates its in vitro sun protection factor (SPF) by COLIPA method of oil in a cream formulation. The sun protection factor was analyzed by using Optometric LLC, SPF-290S is a recording ultraviolet - visible (UVVIS) spectrophotometer using samples exposed to Xenon arc lamp. The sun protection factor of Moringa fixed oil cream exhibited less activity (SPF= 2.04±0.02) suggesting it can be used to maintain the natural pigmentation of the skin or can be used as an adjuvant in other formulations to enhance the activity. SPF of formulation was found 1.46 with ultra boot star rating 1 which approaches toward sunscreen activity.

Baviskar S.R.,Mgvs Pharmacy College | Patil S.H.,Mgvs Pharmacy College
International Journal of PharmTech Research | Year: 2014

Solid phase transformations (SPTs) during pharmaceutical manufacturing processes are well known but difficult to predict and often difficult to control. The quality and performance of a solid oral dosage form depends on the choice of the solid phase, the formulation design, and the manufacturing process. The potential for process-induced solid phase transformations must be evaluated during design and development of formulations and manufacturing processes. This article briefly reviews the basic principles of polymorphism, defines the classes of phase transformation and the underlying transformation mechanisms, and discusses respective kinetic factors. The potential phase transformations associated with common unit operations employed in manufacturing solid oral dosage forms are highlighted. Specific examples are given to illustrate the importance of solid phases, and process-induced phase transitions in formulation and process development. © 2014, Sphinx Knowledge House. All rights reserved.

Nirwane A.M.,MGVs Pharmacy College | Bapat A.R.,MGVs Pharmacy College
Der Pharmacia Lettre | Year: 2012

Piper nigrum popularly known as 'Black Pepper' contains abundant amount of piperine alkaloids. Piperine alkaloids have been implicated in Hepatoprotective activity. To evaluate effect of methanolic extract of Piper nigrum fruits in Ethanol-CCl 4 induced hepatotoxicityWistar rats. The methanolic extract of P. nigrum (MEPN) (100 and 200 mg/kg, p.o., 15 days) and Piperine (PPR) (50 mg/kg, p.o., 15 days) was gavaged daily to the rats along with Ethanol [40%,2ml/100gm,p.o. for 15 days, twice a day] & on 14th Day CCL 4 [1:1 in groundnut oil, 0.1 ml/kg,s.c.]. The levels of Triglycerides (TG), aminotranferases (AST, ALT), alkaline phosphatase (ALP), Bilirubin and Superoxide dismutase (SOD), Catalase (CAT), Glutathione reductase (GSH) and Lipid peroxidation (TBARS) levels in liver were measured. Morphological and histopathological indices in the liver of healthy and Ethanol-CCl 4 treated rats were also measured. In the underlying study, Ethanol- CCl 4 exhibited increase in the hepatic biomarkers (TG, AST, ALT, ALP, and Bilirubin), LPO which were significantly decreased after pretreatment with MEPN (100, 200 mg/kg) and PPR (50 mg/kg). Ethanol- CCl 4 significantly decreased levels of SOD, CAT, and GSH which were restored with MEPN and PPR. The results were similar to that of Liv52 [1ml/kg, p.o. for 15 days], which served as a reference standard. Histopathological studies were also in agreement of above. The study indicates that P. nigrum possess potential hepatoprotective activity which may be attributed to its piperine alkaloids, having therapeutic potential in treatment of liver disorders.

Rote A.R.,MGVs Pharmacy College | Bhalerao S.R.,MGVs Pharmacy College
E-Journal of Chemistry | Year: 2010

Three new simple, economic spectrophotometric methods were developed and validated for the estimation of nabumetone in bulk and tablet dosage form. First method includes determination of nabumetone at absorption maxima 330 nm, second method applied was area under curve for analysis of nabumetone in the wavelength range of 326-334 nm and third method was First order derivative spectra with scaling factor 4. Beer law obeyed in the concentration range of 10-30 μg/mL for all three methods. The correlation coefficients were found to be 0.9997, 0.9998 and 0.9998 by absorption maxima, area under curve and first order derivative spectra. Results of analysis were validated statistically and by performing recovery studies. The mean percent recoveries were found satisfactory for all three methods. The developed methods were also compared statistically using one way ANOVA. The proposed methods have been successfully applied for the estimation of nabumetone in bulk and pharmaceutical tablet dosage form.

Shewale P.B.,MGVs Pharmacy College | Patil R.A.,MGVs Pharmacy College | Hiray Y.A.,MGVs Pharmacy College
Indian Journal of Pharmacology | Year: 2012

Aim: Flowers of Hibiscus rosa-sinensis Linn (Malvaceae) popularly known as "China-rose flowers" contain flavonoids. Flavonoids have been found to have antidepressant activity. The aim of the present study is to evaluate the antidepressant activity of flavonoids in H. rosa-sinensis flowers with possible involvement of monoamines. Materials and Methods: Anti-depressant activity of methanol extract containing anthocyanins (MHR) (30 and 100 mg/kg) and anthocyanidins (AHR) (30 and 100 mg/kg) of H. rosa-sinensis flowers were evaluated in mice using behavioral tests such as tail suspension test (TST) and forced swim test (FST). The mechanism of action involved in antidepressant activity was investigated by observing the effect of extract after pre-treatment with low dose haloperidol, prazosin and para-chlorophenylalanine (p-CPA). Results: Present study exhibited significant decrease in immobility time in TST and FST, similar to that of imipramine (10 mg/kg, i.p.) which served as a positive control. The extract significantly attenuated the duration of immobility induced by Haloperidol (50 g/kg, i.p., a classical D 2-like dopamine receptor antagonist), Prazosin (62.5 g/kg, i.p., an 1-adrenoceptor antagonist) and p-chlorophenylalanine (100 mg/kg, i.p., × 3 days; an inhibitor of serotonin synthesis) in both TST and FST. Conclusion: It can be concluded that MHR and AHR possess potential antidepressant activity (through dopaminergic, noradrenergic and serotonergic mechanisms) and has therapeutic potential in the treatment of CNS disorders and provides evidence at least at preclinical levels.

Gharate M.,MGVs Pharmacy College | Kasture V.,Pinnacle Biomedical Institute of Research and Education
Oriental Pharmacy and Experimental Medicine | Year: 2013

Punarnavasava, an Ayurvedic liquid dosage form containing self generated alcohol is commonly used to treat inflammatory conditions and edema. In the present study, we evaluated anti-inflammatory, analgesic, antipyretic, and antiulcer activity of three different brands of Punarnavasava. The formulation significantly inhibited carrageenan-induced rat paw edema, cotton pellet-induced granuloma, formalin-induced paw licking, yeast induced hyperpyrexia and pyloric ligated ulcers in rats. The study concludes that Punarnavasava has anti-inflammatory, central as well as peripheral antinociceptive, antipyretic and antiulcer activity and thus justifies its use in inflammatory conditions. © 2012 Institute of Oriental Medicine, Kyung Hee University.

Mohan M.,Mgvs Pharmacy College | Kamble S.,Mgvs Pharmacy College | Gadhi P.,Computerised Laboratory | Kasture S.,Pinnacle Biomedical Research Institute
Food and Chemical Toxicology | Year: 2010

Nephrotoxicity is one of the important side effects of anthracycline antibiotics. The aim of the study was to determine the protective effect of Solanum torvum on doxorubicin-induced nephrotoxicity in rats using biochemical and histopathological approaches. Oxidative stress is the main factor in doxorubicin (DOX) induced nephrotoxicity. Wistar rats received either DOX (67.75 mg/kg, i.v, 2 days before sacrifice) or S. torvum (100 mg/kg and 300 mg/kg, p.o.) prior to DOX treatment or S. torvum (100 mg/kg and 300 mg/kg, p.o.) extract alone for 4 weeks. Nephrotoxicity was assessed by measuring the abnormal levels of serum creatinine and blood urea nitrogen (BUN). The anti-oxidant defence enzymes superoxide dismutase (SOD) and catalase (CAT) of kidney tissue were also measured at the end of the treatment schedule. Treatment with S. torvum (100 mg/kg and 300 mg/kg) significantly (p < 0.05) decreased the levels of creatinine and BUN and significantly (p < 0.05) increased the anti-oxidant defence enzyme levels of SOD and CAT. Histopathological changes showed that DOX caused significant structural damages to kidneys like tubular necrosis, renal lesions and glomerular congestion which was reversed with S. torvum. The results suggest that S. torvum has the potential in preventing the nephrotoxicity induced by doxorubicin. © 2009 Elsevier Ltd. All rights reserved.

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