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Gondivkar S.M.,Mgvs Kbh Dental College And Hospital | Gadbail A.R.,Sharad Pawar Dental College and Hospital | Chole R.,Peoples Dental Academy | Parikh R.V.,New Radhika Housing Society
Oral Oncology | Year: 2011

Ossifying fibromas are uncommon benign tumors of the craniofacial skeleton thought to originate from the periodontal ligament. Most are small and incidentally diagnosed with routine dental radiographs. With larger lesions, patients may complain of an abnormal bite or an enlarging mass. This tumor involves slow-evolving growth with deforming swelling generally arising in the mandible, with possible early tooth displacement. From the radiological perspective, more than 50% of the lesions exhibit an expansion of the jaws and 53% shows well-defined unilocular radiolucencies and 40% are mixed radiolucent-radiopaque lesions. The lesions exceptionally can be radiopaque. Ossifying fibroma presents several variant histopathological subtypes. The overlapping clinical and histopathological features of these subtypes have led to diagnostic dilemma and confusion. Complete excision of this tumor has become a necessity since it is notorious for recurrence. We present here two cases of ossifying fibroma of the jaws along with insight into the literature review. © 2010 Elsevier Ltd. All rights reserved.


Chole R.H.,Modern Medicine | Gondivkar S.M.,Mgvs Kbh Dental College And Hospital | Gadbail A.R.,Sharad Pawar Dental College and Hospital | Chaudhary S.,Sdks Dental College And Hospital | And 4 more authors.
Oral Oncology | Year: 2012

This study undertook a review of the literature on drug treatment of oral submucous fibrosis. An electronic search was carried out for articles published between January 1960 to November 2011. Studies with high level of evidence were included. The levels of evidence of the articles were classified after the guidelines of the Oxford Centre for Evidence-Based Medicine. The main outcome measures used were improvement in oral ulceration, burning sensation, blanching and trismus. Only 13 publications showed a high level of evidence (3 randomized controlled trials and 10 clinical trials/controlled clinical trials), with a total of 1157 patients. Drugs like steroids, hyaluronidase, human placenta extracts, chymotrypsin and collagenase, pentoxifylline, nylidrin hydrochloride, iron and multivitamin supplements including lycopene, have been used. Only systemic agents were associated with few adverse effects like gastritis, gastric irritation and peripheral flushing with pentoxifylline, and flushingly warm skin with nylidrin hydrochloride; all other side-effects were mild and mainly local. Few studies with high levels of evidence were found. The drug treatment that is currently available for oral submucous fibrosis is clearly inadequate. There is a need for high-quality randomized controlled trials with carefully selected and standardized outcome measures. © 2011 Elsevier Ltd. All rights reserved.


Gadbail A.R.,Datta Meghe Institute of Medical Sciences | Mankar M.P.,Datta Meghe Institute of Medical Sciences | Hande A.,Datta Meghe Institute of Medical Sciences | Chaudhary M.S.,Datta Meghe Institute of Medical Sciences | And 4 more authors.
Head and Neck | Year: 2013

Background The purpose of this study was to assess and compare angiogenesis in ameloblastoma, keratocystic odontogenic tumors, dentigerous cysts, and normal oral mucosa. Methods Angiogenesis was assessed in 28 ameloblastoma-36 keratocystic odontogenic tumors, 28 dentigerous cysts, and 19 normal oral mucosa by measuring the mean vascular density (MVD), total vascular area (TVA) and mean vascular area (MVA). Immunohistochemistry was carried out by using CD105. Results The nonsignificant difference of MVD was noted between ameloblastoma and keratocystic odontogenic tumors (p =.174). TVA and MVA were significantly higher in ameloblastoma than keratocystic odontogenic tumors, normal oral mucosa, and dentigerous cysts (p <.001). MVD, TVA, and MVA were significantly higher in keratocystic odontogenic tumors than normal oral mucosa and dentigerous cysts (p <.001). Conclusion The results suggest that tumor angiogenesis may play an important role in locally invasive aggressive biologic behavior of ameloblastoma and keratocystic odontogenic tumor. The angiogenesis could be a potent target for developing antiangiogenic therapeutic strategies, particularly in recurrent cases of odontogenic tumors. © 2011 Wiley Periodicals, Inc.


Soundarya N.,M R Ambedkar Dental College | Sharada P.,Dental science and Research Center | Prakash N.,MGVs KBH Dental College and Hospital | Pradeep G.L.,MGVs KBH Dental College and Hospital
Journal of Oral and Maxillofacial Pathology | Year: 2011

Brown tumors are erosive bony lesions caused by rapid osteoclastic activity and peritrabecular fibrosis due to hyperparathyroidism, resulting in a local destructive phenomenon. The classical "brown tumor" is commonly seen in ends of long bones, the pelvis and ribs. Facial involvement is rare and, when present, usually involves the mandible. We report a case of 60-yearold male with a rare initial presentation of primary hyperparathyroidism with bilateral maxillary brown tumors. The present case represents the third report of the bilateral maxillary brown tumors in a patient with primary hyperparathyroidism. Differential diagnosis is important for the right treatment choice. It should exclude other giant cell lesions that affect the maxillae.


Gondivkar S.M.,Mgvs Kbh Dental College And Hospital | Gadbail A.R.,Sharad Pawar Dental College and Hospital | Chole R.,Peoples Dental Academy | Parikh R.V.,Parikh Hospital
Oral Oncology | Year: 2011

The adenoid cystic carcinoma is a relatively rare epithelial tumor of the major and minor salivary glands, accounting for about 1% of all malignant tumor of the oral and maxillofacial region. Although it presents a widespread age distribution, peak incidence occurs predominantly among women, between the 5th and 6th decades of life. The clinical and pathological findings typical of this tumor include slow growth, perineural invasion, potential local recurrence and distant metastasis. Histopathologically it is composed of basaloid cells with primarily myoepithelial/basal cell differentiation. It presents three patterns, cribriform, tubular and solid; the solid type is related to a poor prognosis contrary to the cribriform type, which has a better prognosis. Surgical excision with wide margins is the treatment of choice, if it metastasizes to lymph nodules, post surgical radiotherapy is recommended. We presented herein the case of a 45 year old female patient who presented a palatal lesion, which was treated with surgery and radiotherapy as an additional treatment. We also described a brief literature review of adenoid cystic carcinoma. © 2011 Elsevier Ltd. All rights reserved.


Chaudhary M.,Datta Meghe Institute of Medical Sciences | Gadbail A.R.,Datta Meghe Institute of Medical Sciences | Vidhale G.,Datta Meghe Institute of Medical Sciences | Mankar M.P.,Datta Meghe Institute of Medical Sciences | And 3 more authors.
Head and Neck Pathology | Year: 2012

The aim was to evaluate and compare the presence of myofibroblasts in oral squamous cell carcinoma (OSCC), verrucous carcinoma (VC), high-risk epithelial dysplasia (HRED), low-risk epithelial dysplasia (LRED), and normal oral mucosa (NOM). The study consisted of 37 OSCC, 15 VC, 15 HRED, 15 LRED and 15 NOM. α-smooth muscle actin (α-SMA) antibody was used to identify myofibroblasts. The α-SMA expression was not observed in NOM and LRED. The α-SMA was expressed in 97.29% of OSCC, 86.66% of VC, 46.66 % of HRED. The α-SMA expression was significantly higher in OSCC than VC (p = 0.023) and HRED (p < 0.000). The α-SMA expression was significantly higher in VC than HRED (p = 0.043). Myofibroblastic expression, as highlighted by α-SMA, is undetectable in NOM and LRED but increases as the disease progresses from potentially malignant disorders, as HRED to VC to invasive OSCC. Thus, proliferation of myofibroblasts may be used as a stromal marker of oral premalignancy and malignancy. © 2012 Springer Science+Business Media, LLC.


Gondivkar S.M.,Mgvs Kbh Dental College And Hospital | Patel S.,K M Shah Dental College And Hospital | Gadbail A.R.,Sharad Pawar Dental College and Hospital | Gaikwad R.N.,Sharad Pawar Dental College and Hospital | And 2 more authors.
Journal of Forensic and Legal Medicine | Year: 2011

The aim of this study was to identify and compare the different morphological rugae patterns in males and females of western Indian population, which may be an additional method of identification in cases of crimes or aircraft accidents. A total of 108 plaster casts, equally distributed between the sexes and belonging to similar age-group, were examined for different biometric characteristics of the palatal rugae including number, shape, length, direction and unification and their incidence recorded. Association between these rugae biometric characteristics and sex were tested using chi-square analysis and statistical descriptors were identified for each of these parameters using the SPSS 15.0. The study revealed a statistically significant difference in the total number of rugae between the two sexes (P = 0.000). The different types of rugae between the males and females were statistically compared. The female showed a highly significant difference in the sinuous (P = 0.002) and primary type (P = 0.000) while the male had a significant difference in the unification (P = 0.005). The predominant direction of the rugae was found to be forward relative to backward. It may be concluded that the rugae pattern can be an additional method of differentiation between the male and female in conjunction with the other methods such as visual, fingerprints, and dental characteristics in forensic sciences. © 2011 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.


Gondivkar S.M.,Mgvs Kbh Dental College And Hospital | Parikh R.V.,New Radhika Housing Society and 3 | Gadbail A.R.,Sharad Pawar Dental College and Hospital | Solanke V.,HSRS Dental College and Hospital | And 3 more authors.
Oral Oncology | Year: 2012

The incidence of head and neck cancer remains high and is associated with many deaths in both Western and Asian countries. Common risk factors in head and neck carcinoma are smoking and alcohol abuse, however, in an increasing proportion of cases, no significant smoking or drinking history has been reported. The infectious nature of oncogenic viruses sets them apart from other carcinogenic agents. As such, a thorough study of both the pathogenesis of viral infection and the host response is crucial to a full understanding of the resulting cancers. Such an understanding, in turn, has increased our knowledge of cellular pathways involved in growth and differentiation and neoplasia as a whole. Even though human oncogenic viruses belong to different virus families and utilize diverse strategies to contribute to cancer development, they share many common features. Viruses linked to cancers in humans are the human papilloma viruses, Epstein-Barr virus, hepatitis C virus and human herpesvirus-8. The potential role and involvement of these viruses in head and neck cancers along with brief description of vaccine development is provided. © 2011 Elsevier Ltd. All rights reserved.


Gondivkar S.M.,Mgvs Kbh Dental College And Hospital | Gadbail A.R.,Sharad Pawar Dental College and Hospital | Chole R.,VSPM Dental College and Hospital | Mankar M.,Sharad Pawar Dental College and Hospital | Yuwanati M.,Peoples Dental Academy
Experimental Oncology | Year: 2013

Substantial evidence supports an association between periodontal disease and several systemic diseases including cardiovascular diseases, diabetes mellitus, respiratory diseases, adverse pregnancy outcomes, osteoporosis etc. Periodontal disease, a chronic inflammatory condition, is highly prevalent in adult populations around the world, and may be preventable. Estimates of prevalence vary between races and geographic regions, with a marked increase in the occurrence of periodontal disease with advancing age. Worldwide estimates for the prevalence of severe periodontal disease generally range from 10 to 15%. The relationship between periodontal disease and cancer has been examined for a number of specific cancer sites. The grim statistics of head and neck cancer incidence and survival have remained essentially unchanged over the past 3 decades despite the prevention efforts against known risk factors of head and neck cancer, and advances in the diagnosis and treatment, arguing forcibly for new insights regarding the etiology as well as the strategies for prevention. Recent reports have linked periodontal disease with increased risk of squamous cell carcinoma of head and neck. This review provides current literature for a role of periodontal disease in carcinogenesis of head and neck region and discusses possible biological mechanisms involved. © Experimental Oncology, 2013.


PubMed | MGVS KBH Dental College and Hospital
Type: Journal Article | Journal: Contemporary clinical dentistry | Year: 2016

Oral cancer is the most life-threatening disease of oral tissues. In societies where the incidence of oral cancer is high, clinically recognizable premalignant lesions are particularly common. Diagnosing oral cancers at an early stage is critical in improving the survival rate and reducing the morbidity associated with the disease. Alterations in the sialic acid levels in cancer patients have stimulated interest in this sugar residue as a possible tumor marker.The purpose of this study was to estimate the salivary sialic acid levels in patients with oral premalignancy and squamous cell carcinoma and to correlate it with their grades to develop a cost-effective and noninvasive diagnostic parameter.Unstimulated whole saliva was collected from the groups under study and subjected to biochemical analysis for determination of sialic acid levels.The salivary sialic acid levels were correlated with the clinical stage and histological grade by one-way ANOVA (SPSS software version 15).Salivary sialic acid was elevated in oral squamous cell carcinoma (OSCC) compared to oral premalignancy and control group. A statistically significant correlation was observed between the grades of squamous cell carcinoma, grades of dysplasia in premalignancy, and sialic acid level.Evaluation of salivary sialic acid levels in premalignant and malignant lesions can serve as a screening tool. The mortality and morbidity of OSCC can be reduced if the lesions are diagnosed in early precancerous states using such noninvasive diagnostic methods for screening and monitoring of the population.

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