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Sevagram, India

Bahekar S.E.,Institute of Medical science and Research Center | Kale R.S.,MGIMS
Journal of Ayurveda and Integrative Medicine | Year: 2015

Background: Use of Manihot esculenta Crantz (MEC) plant has been mentioned in literature of Food and Agriculture Organization of United Nations, Central Tuber Crops Research Institute and many others. It is also known commonly as tapioca, continues to be a crop of food security for the millions of people, especially in the developing countries of the globe including India. Medicinal uses of this plant including diarrhea have been mentioned in literature, but scientific evidence is lacking. Objective: The objective was to study antidiarrheal activity of ethanolic leaf extract of MEC in Wistar rats. Materials and Methods: Ethanolic extract of MEC leaves in the doses of 50 mg/kg, 100 mg/kg and 200 mg/kg were used in Wistar rats of either sex. Experimental models used were castor oil-induced intestinal fluid accumulation and charcoal passage test. Loperamide and atropine sulfate were the standard drugs used in these models respectively. Results: MEC extracts decreased intestinal fluid volume in dose dependent manner no extract group was comparable with standard drug loperamide (5 mg/kg). MEC extracts also significantly inhibited gastrointestinal motility in dose dependent manner. MEC (100 mg/kg) and MEC (200 mg/kg) were comparable with standard drug atropine sulfate (5 mg/kg) in this aspect. <0.05 were considered to be significant. Conclusions: Ethanolic extract of MEC leaves exhibited significant antidiarrheal activity by decreasing intestinal fluid accumulation and the gastrointestinal motility in Wistar rats.

Jain A.P.,MGIMS | Aggarwal K.K.,Moolchand Med City | Zhang P.-Y.,Xuzhou Central Hospital
European Review for Medical and Pharmacological Sciences | Year: 2015

Cardioceuticals are nutritional supplements that contain all the essential nutrients including vitamins, minerals, omega-3-fatty acids and other antioxidants like a-lipoic acid and coenzyme Q10 in the right proportion that provide all round protection tothe heart by reducing the most common risks associated with the cardiovascular disease including high low-density lipoprotein cholesterol and triglyceride levels and factors that contribute to coagulation of blood. Omega-3 fatty acids have been shown to significantly reduce the risk for sudden death caused by cardiac arrhythmias and all-cause mortality in patients with known coronary heart disease. Omega-3 fatty acids are also used to treat hyperlipidemia and hypertension. There are no significant drug interactions with omega-3 fatty acids. The American Heart Association recommends consumption of two servings of fish per week for persons with no history of coronary heart disease and at least one serving of fish daily for those with knowncoronary heart disease. Approximately 1 g/day of eicosapentaenoic acid plus docosahexaenoic acid is recommended for cardio protection. Higher dosages of omega-3 fatty acids are required to reduce elevated triglyceride levels (2-4 g/day). Modest decreases in blood pressure occur with significantly higher dosages of omega-3 fatty acids.

Rakholia R.,Government Medical College | Chaturvedi P.,MGIMS
Nigerian Journal of Clinical Practice | Year: 2013

Objective: To determine the prevalence of thalassemia in Sindhi community of Wardha and evaluation of risk factors. To give genetic counseling to those diagnosed as carriers. Study Design: Cross-sectional (prevalence study). Setting: Sindhi community residing in and around Wardha. Study Period: 18 months. Materials and Methods: A total of 578 individuals belonging to Sindhi community residing in and around Wardha in India were selected by systemic randomization. Those who fulfilled the inclusion criteria and voluntarily gave consent were subject to Naked Eye Single Tube Rapid Osmotic Fragility Test (Nestroft). Those found positive by Nestroft were labeled carriers and advised to undergo Hemoglobin A2 (HbA2) quantification for confirmation of carrier status. Carriers thus identified were given genetic counseling. Result: The mean age of study population was 15.06 years with a range of 3-28 years. The largest group consisted of those between 12 and 18 years. The prevalence of thalassemia carrier state as diagnosed by Nestroft is 36.36% (200/550) and incidence of carrier state by HbA2 quantification in the study population was 17.2% (95/550). Conclusion: Prevalence of thalassemia in the Sindhi community of Wardha is higher than in other studies and equal to the highest prevalent communities in India. Thus, we recommend that urgent measures to increase awareness and control the disease be taken.

Khandekar I.,MGIMS
Journal of Indian Academy of Forensic Medicine | Year: 2013

In India it is prevalent practice that whenever the allegation of sexual assault or rape is made, the suspected or alleged accused is medically examined by the doctors on the request of investigating officer. Relevance of the most archaic practice, collection of semen of the alleged accused by the doctors needs debate and discussion. This practice causes wastage of time and resources of the health and home department and delay in disposal of cases leading to backlog and huge burden on judiciary. This study is pertaining to the various queries asked in the requisition letter given by the police officials to the doctors at the time of Forensic Medical Examination of the alleged accused and the collection of semen sample of the accused for the identification of blood group at the request of police. Various forensic samples are collected from the accused to link them with the crime. This study discusses the purpose and relevance of collection of semen of the alleged accused of rape and also discusses the suggestion to overcome the problems.

Kumar N.,Pravara Rural Hospital and Medical College | Chilke D.,Pravara Rural Hospital and Medical College | Puttewar M.P.,MGIMS
Indian Journal of Otolaryngology and Head and Neck Surgery | Year: 2012

Otitis media is an important and a highly prevalent disease of the middle ear and poses serious health problem world wide especially in developing countries where large percentage of the population lack specialized medical care, suffer from malnutrition and live in poor hygienic environmental conditions. It has been a general view that the hearing loss increases with the size of the perforation, more so if it is in the posterio inferior quadrant. It was found that the maximum average loss occurred at 250 Hz. The hearing loss is less in small perforations (less than 2 mm diameter) then in larger ones; less in perforations touching the manubrium than in those away from it, and also less in perforations of the anterioinferior quadrant than in those on posterio-inferior quadrant. A normally functioning eustachian tube is also an essential physiologic requirement for a healthy middle ear and normal hearing. © 2011 Association of Otolaryngologists of India.

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