Aguiniga-Sanchez I.,Postgraduate College |
Aguiniga-Sanchez I.,Mexican Interdisciplinary Research Group on Sechium |
Aguiniga-Sanchez I.,National Autonomous University of Mexico |
Soto-Hernandez M.,Postgraduate College |
And 10 more authors.
Nutrition and Cancer
The antiproliferative potential of a crude extract from the chayote hybrid H-837-07-GISeM® and its potential for apoptosis induction were assessed in leukaemic cell lines and normal mouse bone marrow mononuclear cells (BM-MNCs). The extract strongly inhibited the proliferation of the P388, J774, and WEHI-3 cell lines (with an IC50 below 1.3 g·mL-1), reduced cell viability, and induced apoptotic body production, phosphatidylserine translocation, and DNA fragmentation. However, the extract had no effect on BM-MNCs. We postulate that these properties make the extract a good candidate for an anti-tumour agent for clinical use. © 2015 Copyright © 2015 Taylor & Francis Group, LLC. Source