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Badilla J.,Calle Tecate | Gonzalez-Arias S.,Mexican Institute of Social Security IMSS
Orbit | Year: 2014

Introduction: Total upper and lower eyelid loss due to carcinoma or trauma while conserving a functioning eye is rarely seen. In such cases being able to maintain the ocular surface may prove to be a surgical challenge, more so when there is a history of tumor recurrence, multiple procedures or tissue loss that exceeds the palpebral region, thus limiting the reconstructive options. Case and Technique: We present a case report where a scalping forehead transposition flap pedicled on the superficial temporal artery territory was performed to reconstruct a full thickness skin defect that involved the dorsum of the nose, cheek, upper and lower eyelids. A conjunctival advancement flap for ocular surface protection was used that unexpectedly rendered a cystic cavity that functioned as a tissue expander. Comment: Although the technique requires at least two surgical stages, we recommend this approach when other options are not feasible. © 2014 Informa Healthcare USA, Inc.

Rivas-Santiago C.E.,Rutgers University | Hernandez-Pando R.,National Institute of Medical science and Nutrition Salvador Zubiran | Rivas-Santiago B.,Mexican Institute of Social Security IMSS
Immunotherapy | Year: 2013

TB is an infectious disease that still has an enormous impact on public health worldwide. With the continuous increasing epidemic of multidrug-resistant TB, new drugs and vaccines are urgently needed. In the last decade there has been a broad advance in the knowledge of innate immunity in TB. Together with the growing research regarding immunomodulators, new promising insights have been developed that can contribute in the control of TB. This is the case of antimicrobial peptides, which can be potential therapeutic or adjuvant agents. The current high cost of antimicrobial peptide synthesis may be a current deterrent for treatment; antimicrobial peptide-inducers can be an alternative for low-cost treatment and/or adjuvants. © 2013 Future Medicine Ltd.

Rivas-Santiago B.,Mexican Institute of Social Security IMSS | Cervantes-Villagrana A.R.,Autonomous University of Zacatecas
Scandinavian Journal of Infectious Diseases | Year: 2014

It is estimated that there are approximately eight million new cases of active tuberculosis (TB) worldwide annually. There is only 1 vaccine available for prevention: bacillus Calmette-Guérin (BCG). This has variable efficacy and is only protective for certain extrapulmonary TB cases in children, therefore new strategies for the creation of novel vaccines have emerged. One of the promising approaches is the DNA vaccine, used as a direct vaccination or as a prime-boost vaccine. This review describes the experimental data obtained during the design of DNA vaccines for TB. © 2014 Informa Healthcare.

Varqa A.N.,Mexican Institute of Social Security IMSS
ecancermedicalscience | Year: 2014

Ovarian cancer is a disease laden with paradigms, and it is a serious health problem. It is important to know its natural history, as it is multifactorial in origin, and also to understand its behaviour given its risk factors which can lead to death from metastasis in patients. It continues to be a challenge for oncologists. An analytical literature review was performed to update the latest concepts of its origin, evolution, risk factors, pre-clinical horizon, and its clinical manifestations; until the death of the patient. © the authors; licensee ecancermedicalscience.

Gutierrez J.P.,National Health Research Institute | Garcia-Saiso S.,Ministryof Health | Dolci G.F.,Mexican Institute of Social Security IMSS | Avila M.H.,National Institute of Public Health INSP
BMC Health Services Research | Year: 2014

Background: Effective access measures are intended to reflect progress toward universal health coverage. This study proposes an operative approach to measuring effective access: in addition to the lack of financial protection, the willingness to make out-of-pocket payments for health care signifies a lack of effective access to pre-paid services. Methods. Using data from a nationally representative health survey in Mexico, effective access at the individual level was determined by combining financial protection and effective utilization of pre-paid health services as required. The measure of effective access was estimated overall, by sex, by socioeconomic level, and by federal state for 2006 and 2012. Results: In 2012, 48.49% of the Mexican population had no effective access to health services. Though this represents an improvement since 2006, when 65.9% lacked effective access, it still constitutes a major challenge for the health system. Effective access in Mexico presents significant heterogeneity in terms of federal state and socioeconomic level. Conclusions: Measuring effective access will contribute to better target strategies toward universal health coverage. The analysis presented here highlights a need to improve quality, availability, and opportuneness (location and time) of health services provision in Mexico. © 2014 Gutiérrez et al.; licensee BioMed Central Ltd.

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