Mexican Group for Basic and Clinical Research in Internal Medicine

Mexico City, Mexico

Mexican Group for Basic and Clinical Research in Internal Medicine

Mexico City, Mexico

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PubMed | Hospital General Of Ticoman Ss Df and Mexican Group for Basic and Clinical Research in Internal Medicine
Type: Journal Article | Journal: Therapeutic advances in cardiovascular disease | Year: 2016

Hyperuricemia leads to endothelial dysfunction and insulin resistance, and has been associated with diseases such as hypertension. Antihypertensive drugs modify serum uric acid levels, however, few data are available about their combinations on uricemia. In this study we evaluate the effect of two combinations of losartan, with amlodipine or with hydrochlorothiazide, on serum uric acid levels in hypertensive patients.A total of 60 hypertensive patients were randomized in two groups; group LA received losartan/amlodipine (100/5 mg) once a day, whereas LH group received losartan hydrochlorothiazide (100/12.5 mg) once a day for 3 months. In both groups serum uric acid levels were measured at the beginning and end of the study. Patients were evaluated monthly for blood pressure (BP) and adverse events. Statistical analysis was performed with a two-way analysis of variance (ANOVA) for repeated measures.All patients experienced a significant reduction of BP to the same extent (LA 155/94 to 123/79, LH 157/92 to 124/78 mmHg, p > 0.05). In the LA group, serum uric acid decreased from 6.5 1.6 to 4.6 1.3 mg/ml ( p = 0.0001), whereas in the LH group there was a nonsignificant increase from 5.82 1.4 to 5.85 1.5 mg/ml, ( p = 0.936). When both groups were compared, we found a significant reduction ( p < 0.00013) on serum uric acid levels in the LA group.Both combinations decrease BP values to the same extent, however, LA combination showed a reduction on serum uric acid levels, which may contribute to a reduction in the metabolic risk in hypertensive patients.


Rubio-Guerra A.F.,Hospital General Of Ticoman | Rubio-Guerra A.F.,Mexican Group for Basic and Clinical Research in Internal Medicine | Cabrera-Miranda L.J.,Hospital General Of Ticoman | Vargas-Robles H.,CINVESTAV | And 4 more authors.
Cardiology (Switzerland) | Year: 2013

Background: Hypoadiponectinemia and hyperresistinemia are associated with cardiovascular disease. The increase in the carotid intima-media thickness (CIMT) assessed by B-mode ultrasound has been directly associated with increased risk of myocardial infarction and stroke. Objective: To evaluate the correlation between adipokine levels with CIMT in hypertensive type 2 diabetic patients. Methods: Serum levels of adiponectin and resistin levels were measured by ELISA in 30 type 2 diabetic patients with never-treated hypertension and in age-matched healthy controls. The CIMT (B-mode color imaging of extracranial carotid arteries using high-resolution ultrasound) was also obtained. The relationship between adipokine levels and the adiponectin/resistin index with the CIMT was assessed by the Pearson correlation coefficient test. Results: Adiponectin was lower (p < 0.05), and resistin higher (p < 0.01) in patients than in controls, CIMT correlated positively with resistin (R = 0.45, p < 0.02) and the adiponectin/resistin index (R = 0.58, p < 0.001), but not with adiponectin levels (r =-0.11, p > 0.1) in patients. Whereas only adiponectin levels correlated-negatively-with CIMT (r =-0.39, p < 0.02) in controls. Conclusion: Our results shown that the adiponectin/resistin index seems to be more strongly associated with atherosclerosis than adipokine levels, and may be used as a reliable marker of cardiovascular risk in type 2 diabetic hypertensive patients. Copyright © 2013 S. Karger AG, Basel.


Rubio-Guerra A.F.,Hospital General Of Ticoman | Rubio-Guerra A.F.,Mexican Group for Basic and Clinical Research in Internal Medicine | Vargas-Robles H.,National Polytechnic Institute of Mexico | Suarez-Cuenca J.A.,Mexican Group for Basic and Clinical Research in Internal Medicine | And 7 more authors.
Medicina Interna de Mexico | Year: 2014

Background: Adipocytokines are adipocyte-secreted peptides that are involved in the pathways that lead to insulin resistance, inflammation and the development of cardiovascular disease. Objective: To evaluate the levels of the adipocytokines resistin and adiponectin in normotensive and hypertensive diabetic patients. Material and methods: Clinical and transversal study; circulating levels of resistin and adiponectin were measured by ELISA (RyDSystems Minneapolis) in 80 type-2 diabetic patients (40 normotensive and 40 hypertensive naïve to antihypertensive therapy), and in 40 normotensive non-diabetic subjects. Statistical analysis was performed with ANOVA. Results: We found a non-significantly decreased levels of resistin in control group when compared with diabetic normotensive patients, (13.5 vs 16.7 ng/mL p > 0.05); however, the coexistence of hypertension increased significantly (25.9 ng/mL p < 0.005) those values. We also observed increased values of adiponectin in control group when compared with diabetic normotensive patients (9.6 vs 7.5 μg/mL, p<0.05), but the coexistence of hypertension did not modified those values significantly (7.4 μg/dL p>0.05). Conclusions: Diabetic patients have increased levels of resistin and lower values of adiponectin when compared with non diabetic subjects, coexistence of hypertension increase the levels of resistin but do not modified adiponectin values, this may explain why diabetic patients (hypertensive or not) had more complications than normotensive patients.

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