Ustunkar G.,METU - MEMS Center
Journal of integrative bioinformatics | Year: 2011
Recently, there has been increasing research to discover genomic biomarkers, haplotypes, and potentially other variables that together contribute to the development of diseases. Single Nucleotide Polymorphisms (SNPs) are the most common form of genomic variations and they can represent an individual’s genetic variability in greatest detail. Genome-wide association studies (GWAS) of SNPs, high-dimensional case-control studies, are among the most promising approaches for identifying disease causing variants. METU-SNP software is a Java based integrated desktop application specifically designed for the prioritization of SNP biomarkers and the discovery of genes and pathways related to diseases via analysis of the GWAS case-control data. Outputs of METU-SNP can easily be utilized for the downstream biomarkers research to allow the prediction and the diagnosis of diseases and other personalized medical approaches. Here, we introduce and describe the system functionality and architecture of the METU-SNP. We believe that the METU-SNP will help researchers with the reliable identification of SNPs that are involved in the etiology of complex diseases, ultimately supporting the development of personalized medicine approaches and targeted drug discoveries.
Onat Y.,University of Hawaii at Manoa |
Yalciner A.C.,METU - MEMS Center
Ocean Engineering | Year: 2013
The highly active seismic potential of Eastern Mediterranean raises a question about risk mitigation when a possible tsunami hits the coastline. A proper risk mitigation plan and tsunami assessment can be achieved by creating a fully detailed database. In this study, 38 scenarios created using this database on bathymetric and topographic data in sufficient resolution using valid and verified numerical tool called NAMI DANCE, helps us to understand the tsunami generation, propagation, coastal inundation aided by visualization. The uncertainties in defining seismic source parameters and the effect of dip and rake (slip) angle are discussed. The performance and efficiency of the numerical code, the accuracy of the results in the application to Eastern Mediterranean Tsunamis and the comparisons of simulation results in nested domains for the towns of Iskenderun and Kas are given as case studies. According to this study, north-west and south-west of Turkey may have tsunami risks more than the other regions. The maximum wave amplitudes that hit the coasts are more than 4 m and about 6 m at some localities. The arrival time of the first wave to hit the coast varies between 15 min to 60 min depending on the proximity to the source location. © 2013 Elsevier Ltd.
Bilgin H.F.,TUBITAK - Marmara Research Center |
Ermis M.,METU - MEMS Center
Electric Power Systems Research | Year: 2011
This paper describes the operating principles, design and field performance of two-level, three-leg device commutated current source converter (CSC) topology based Static Synchronous Compensator (STATCOM), which is developed for medium voltage industry applications. In the paper, the relationship between the reactive power and the control variables is obtained, harmonic minimization techniques applicable to CSC are investigated, and then Selective Harmonic Elimination Technique is applied for the elimination of the 5th, 7th, 11th and 13th harmonics in CSC line current. The design principles of the input filter are also set out. Considerations for optimum sizing of STATCOM in common industry applications are described with the design objective of maximum utilization of power semiconductors. Two CSC based STATCOMs, which are rated at ±500 kVAr and 0-1500 kVAr capacitive are implemented and applied to industry. Field results are also given in the paper in order to validate the operating principles and design criteria. © 2010 Elsevier B.V. All rights reserved.
Erkilic M.,METU - MEMS Center
Metu Journal of the Faculty of Architecture | Year: 2011
Universal Design (UD), which is grounded politically and sociologically in the long historic struggle of the anti-discrimination and disability rights movements in the United States that occurred between 1970's and 1990's and the market-oriented necessities of an aging society, has been defined as 'design for all' people to the greatest extent possible, differentiating it from earlier concepts of adaptable, specialised or accessible design. UD argues that the design of a built environment must be usable by 'all people', regardless of age, gender, capability, cultural origin or socioeconomic status. UD incorporates some principles to achieve 'design for all' solutions. Although UD is originated and developed within the discourse on disability, its emphasis on the locution 'design for all', along with the writings of proponents of UD, suggests a deliberate broadening but at the same time avoiding giving focus on the issue of disability. Further evidence of this interpretation of UD's approach can be found in the design products that UD promotes. Most examples of products designed in accordance with UD principles are usable by people with diverse 'disabilities'. Advocates' writings reveal that the conceptual foundations of UD rely socio-politically on the 'rights-based' and 'non-discriminatory' attitudes, which have helped to consolidate the ontologically 'non-stigmatising' and 'inclusionary' status of UD. These attitudes have indirect implications for disability. This paper aims to scrutinize UD's concern with 'design for all' by going beyond its promissory design-related claims and unveiling its underlying conceptual and strategic challenges in relation to disability discourse, referring to the historical developmental process of the discourse of disability and its incidence in UD's emerging processes. Referring to the historical developmental process of disability, one could claim that the formulation of the ideals of UD was influenced by the long path of demedicalisation and universalisation of the status of disability. The social constructionist approach of the Social Model and the Minority Group Model of disability that signify the environmental conditions as the primary source for enabling/disabling of the people with diverse disabilities throughout the demedicalisation process of disability inspired the conceptual strategies and authenticity of UD. Descriptive formulations of disability, developed within the international agencies of ICIDH and ICF in the last three decades, have consistently influenced and supported the universalising and anti- discriminatory strategy of UD. The Social Model's distinction of 'disability' and 'impairment' substantiated UD's concern for a non-stigmatizing, inclusionary attitude which the term 'design for all' suggests. This paper evaluates UD from within by drawing attention to its strong and weak sides referring to the conceptual challenges that arise directly or indirectly with reference to the historical development process of the disability discourse.
Baran M.,Kirikkale University |
Tankut T.,METU - MEMS Center
ACI Structural Journal | Year: 2011
The purpose of this study is to investigate the behavior of reinforced concrete (RC) frames under cyclic loads strengthened by using precast concrete (PC) panels. The idea is to transform the existing hollow brick infills into strong and rigid infills by bonding relatively highstrength PC panels with a thin layer of epoxy mortar. By this method, the seismic behavior of the frame is improved For this purpose-one being reference-a total of 11 one-third scale, one-bay, two-story deficient RC frames were tested under reversed cyclic lateral loads. Six different panel types were used for strengthening purposes. It was observed that the strength, lateral stiffness, and energy dissipation capacity of strengthened frames were significantly improved Copyright © 2011, American Concrete Institute. All rights reserved.