Mettapracharak Wat Rai Khing Hospital

Chiang Rai, Thailand

Mettapracharak Wat Rai Khing Hospital

Chiang Rai, Thailand
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Vongpaisarnsin K.,Chulalongkorn University | Vongpaisarnsin K.,Mettapracharak Wat Rai Khing Hospital
Forensic Science International: Genetics Supplement Series | Year: 2013

Human eye colour is recognized as one of the visible characterized features that would be valuable for forensic identification by predicting these phenotypes with particular genotypes. Recent gene association study had figured the remarkable variants mainly in OCA2 and HERC2 genes. In this study, eight human eye colour single nucleotide polymorphisms (SNPs) in five pigmentation genes, OCA2 (rs7495174, rs4778241 and rs4778138), HERC2 (rs12913832 and rs1667394), SLC24A4 (rs12896399), SLC45A2 (rs16891982) and TYR (rs1393350) were investigated in 374 Thai samples. The homozygote genotypes were predominantly observed in rs16891982 (GG/0.9920), rs1393350 (GG/0.9973) and rs12913832 (AA/0.9866). The allele frequency comparison with other populations in HapMap had identified the major allele of East Asia and Thai. Furthermore, the analysis of haplotype block of HERC2-OCA2 comprised five SNPs (rs12913832, rs1667394, rs7495174, rs4778241 and rs4778138) presented the most haplotype was AG-GAG (0.5199), which was rarely observed in European population. © 2013 Elsevier Ireland Ltd.


Isipradit S.,Mettapracharak Wat Rai Khing Hospital | Sirimaharaj M.,Mettapracharak Wat Rai Khing Hospital | Charukamnoetkanok P.,Mettapracharak Wat Rai Khing Hospital | Thonginnetra O.,Mettapracharak Wat Rai Khing Hospital | And 10 more authors.
PLoS ONE | Year: 2014

Background: The majority of vision loss is preventable or treatable. Population surveys are crucial for planning, implementation, and monitoring policies and interventions to eliminate avoidable blindness and visual impairments. This is the first rapid assessment of avoidable blindness (RAAB) study in Thailand. Methods: A cross-sectional study of a population in Thailand age 50 years old or over aimed to assess the prevalence and causes of blindness and visual impairments. Using the Thailand National Census 2010 as the sampling frame, a stratified four-stage cluster sampling based on a probability proportional to size was conducted in 176 enumeration areas from 11 provinces. Participants received comprehensive eye examination by ophthalmologists. Results: The age and sex adjusted prevalence of blindness (presenting visual acuity (VA) <20/400), severe visual impairment (VA <20/200 but ≥20/400), and moderate visual impairment (VA <20/70 but ≥20/200) were 0.6% (95% CI: 0.5-0.8), 1.3% (95% CI: 1.0-1.6), 12.6% (95% CI: 10.8-14.5). There was no significant difference among the four regions of Thailand. Cataract was the main cause of vision loss accounted for 69.7% of blindness. Cataract surgical coverage in persons was 95.1% for cut off VA of 20/400. Refractive errors, diabetic retinopathy, glaucoma, and corneal opacities were responsible for 6.0%, 5.1%, 4.0%, and 2.0% of blindness respectively. Conclusion: Thailand is on track to achieve the goal of VISION 2020. However, there is still much room for improvement. Policy refinements and innovative interventions are recommended to alleviate blindness and visual impairments especially regarding the backlog of blinding cataract, management of non-communicative, chronic, age-related eye diseases such as glaucoma, age-related macular degeneration, and diabetic retinopathy, prevention of childhood blindness, and establishment of a robust eye health information system. © 2014 Isipradit et al.


PubMed | Mettapracharak Wat Rai Khing Hospital
Type: Journal Article | Journal: PloS one | Year: 2014

The majority of vision loss is preventable or treatable. Population surveys are crucial for planning, implementation, and monitoring policies and interventions to eliminate avoidable blindness and visual impairments. This is the first rapid assessment of avoidable blindness (RAAB) study in Thailand.A cross-sectional study of a population in Thailand age 50 years old or over aimed to assess the prevalence and causes of blindness and visual impairments. Using the Thailand National Census 2010 as the sampling frame, a stratified four-stage cluster sampling based on a probability proportional to size was conducted in 176 enumeration areas from 11 provinces. Participants received comprehensive eye examination by ophthalmologists.The age and sex adjusted prevalence of blindness (presenting visual acuity (VA) <20/400), severe visual impairment (VA <20/200 but 20/400), and moderate visual impairment (VA <20/70 but 20/200) were 0.6% (95% CI: 0.5-0.8), 1.3% (95% CI: 1.0-1.6), 12.6% (95% CI: 10.8-14.5). There was no significant difference among the four regions of Thailand. Cataract was the main cause of vision loss accounted for 69.7% of blindness. Cataract surgical coverage in persons was 95.1% for cut off VA of 20/400. Refractive errors, diabetic retinopathy, glaucoma, and corneal opacities were responsible for 6.0%, 5.1%, 4.0%, and 2.0% of blindness respectively.Thailand is on track to achieve the goal of VISION 2020. However, there is still much room for improvement. Policy refinements and innovative interventions are recommended to alleviate blindness and visual impairments especially regarding the backlog of blinding cataract, management of non-communicative, chronic, age-related eye diseases such as glaucoma, age-related macular degeneration, and diabetic retinopathy, prevention of childhood blindness, and establishment of a robust eye health information system.

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