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Huang T.-L.,China Medical University at Taichung | Huang T.-L.,National Taiwan University | Hsu H.-C.,China Medical University at Taichung | Yao C.-H.,China Medical University at Taichung | And 2 more authors.
Biomedical Engineering - Applications, Basis and Communications | Year: 2011

Although hyaluronans (HA) has been proved to be effective in the treatment of patients with osteoarthritis and rheumatoid arthritis, the correlations between these effects and the molecular weight (MW) of HA have not been systematically followed. Many different HA preparations are now applied worldwide in clinical usage. Their MWs are very wide ranged (5006,000 kDa). No systematic review especially addresses the role of HA's MW in the effects of anti-inflammation and structure protection. This study evaluates the literature of the basic and clinical studies on biological, pathological, and clinical effects of different MW HA. Databases were searched through PubMed (period 19782009), using the terms hyaluronan, hyaluronic acid, arthritis, and MW. Reference lists of relevant articles were controlled for additional references. We define the "high" MW (HMW) as MW greater than 2,000 kDa and define the "low" MW (LMW) as MW less than 2,000 kDa in the current study. Most data that support the structure protective effect of HA are from the studies with LMW HA. On the other hand, the majority of data that recommend the anti-inflammatory effect of HA are from the reports of HMW HA. In conclusion, we suggest that the effects of LMW HA were more structure protective and those of HMW HA were more anti-inflammatory. © 2011 National Taiwan University.


Weng M.-H.,Metal Industry Research and Development Center | Pan C.-T.,National Sun Yat - sen University | Huang C.-W.,National Sun Yat - sen University | Yang R.-Y.,National Pingtung University of Science and Technology
Journal of Nanomaterials | Year: 2014

We investigated the capping layer effect of Si N x (silicon nitride) on the microstructure, electrical, and optical properties of poly-Si (polycrystalline silicon) prepared by aluminum induced crystallization (AIC). The primary multilayer structure comprised Al (30 nm)/Si N x (20 nm)/a-Si (amorphous silicon) layer (100 nm)/ITO coated glass and was then annealed in a low annealing temperature of 350°C with different annealing times, 15, 30, 45, and 60 min. The crystallization properties were analyzed and verified by X-ray diffraction (XRD) and Raman spectra. The grain growth was analyzed via optical microscope (OM) and scanning electron microscopy (SEM). The improved electrical properties such as Hall mobility, resistivity, and dark conductivity were investigated by using Hall and current-voltage (I - V) measurements. The results show that the amorphous silicon film has been effectively induced even at a low temperature of 350°C and a short annealing time of 15 min and indicate that the Si N x capping layer can improve the grain growth and reduce the metal content in the induced poly-Si film. It is found that the large grain size is over 20 m and the carrier mobility values are over 80 cm2/V-s. © 2014 Min-Hang Weng et al.


Hsu S.-F.,National Kaohsiung University of Applied Sciences | Chou J.-H.,National Kaohsiung University of Applied Sciences | Fang C.-H.,National Kaohsiung University of Applied Sciences | Weng M.-H.,Metal Industry Research and Development Center
Advances in Materials Science and Engineering | Year: 2014

We deposited undoped ZnO films on the glass substrate at a low temperature (<70°C) using cathode arc plasma deposition (CAPD) and the grey-relational Taguchi method was used to determine the processing parameters of ZnO thin films. The Taguchi method with an L9 orthogonal array, signal-to-noise (S / N) ratio, and analysis of variance (ANOVA) is employed to investigate the performances in the deposition operations. The effect and optimization of deposition parameters, comprising the Ar: O2 gas flow ratio of 1: 6, 1: 8, and 1: 10, the arc current of 50 A, 60 A, and 70 A, and the deposition time of 5 min, 10 min, and 15 min, on the electrical resistivity and optical transmittance of the ZnO films are studied. The results indicate that, by using the grey-relational Taguchi method, the optical transmittance of ZnO thin films increases from 88.17% to 88.82% and the electrical resistivity decreases from 5.12 × 10 - 3 Ω -cm to 4.38 × 10 - 3 Ω -cm, respectively. © 2014 Shuo-Fu Hsu et al.


Chen Y.C.,University of Science and Technology of China | Huang H.H.,University of Science and Technology of China | Lin J.B.,Metal Industry Research and Development Center
Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science | Year: 2011

In kinematic and compliance testing for suspensions, great importance is attached to the measurement of the instant centre and roll centre. As the suspension construction is truly three-dimensional, the screw axis theory can afford a much more accurate kinematic analysis. The purpose of this study was to present a vector finite displacement method (FSAv) for the kinematic analysis of instant centre and roll centre of suspensions. Two suspension simulation models, with and without approximately singular screw parameter, respectively, were employed to investigate the efficiency of the proposed method. It was found that the FSAv method prevailed over the method of general finite screw axis. In addition, it was not necessary to calculate the velocity matrix from the derivatives. This proposed method, therefore, is suitable for determining the roll centre height and the related parameters of instant centre. Moreover, it can be expanded for the measurement of the kingpin axis as well. © Authors 2011.

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