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Hyanek J.,Metabolicka Ambulance Nemocnice Na Homolce | Hajek Z.,Gynekologicko porodnicka Klinika VFN a 1. LF UK | Dubska L.,Oddeleni Klinicke Biochemie | Pejznochova H.,Oddeleni Klinicke Biochemie | And 11 more authors.
Klinicka Biochemie a Metabolismus | Year: 2011

Objective: Authors are commenting very good experience with routinely use of holotranscobalamin (HTC) in patients attending the metabolic surgery of Hospital Homolka within last 5 yrs. Patients and Method: Among 1000 adult or children patients attending yearly the metabolic surgery the typical cases of HTC deficiency were detected in patients with unexplained neurological, psychiatric, gastroenterological, cardiologic, obstetric, nutritional and metabolic symptoms. The MEIA AxSym Active B-12 Assay (Abbott) method was introduced in routine laboratory use instead of total vitamin B-12 estimation. Results: Typical clinical cases of patients suffering from heart attacks, pulmonary embolism, typical or atypical pernicious anemias as well as in patients with deep vein thrombosis, thromboembolism, in patients with neuronal and perception disorders, in females suffering from fertility disorders are presented in details. All these patients were detected only thanks to introducing of very efficient method for HTC estimation in the routine use in clinical chemical laboratory. Conclusion: In many typical or atypical clinical cases of known or unknown origin, the estimation of active form of vitamin B-12-HTC together with methylmalonic acid and total homocysteine could be very helpful to find the reason for corresponding diagnosis or complications.

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