Ames, IA, United States

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The present invention provides a composition comprising HMB. Methods of administering HMB to an animal are also described. HMB is administered to enhance recovery from soft tissue trauma, including both acute and non-acute soft tissue trauma. Enhanced recovery includes reduced recovery time and enhanced soft tissue healing.


The present invention provides a feed additive composition comprising -hydroxy--methylbutyrate (HMB). Methods of preventing, eliminating and/or reducing microbial contamination in animal feeds, including livestock and poultry feed and companion animal food, including pet foods such as kibble, chews and treats by adding HMB to the animal feed are provided. HMB can be mixed into the animal feed or applied as a coating or glaze.


Patent
Metabolic Technologies, Inc. | Date: 2016-12-27

The present invention provides a composition comprising HMB and Vitamin D. Methods of administering HMB and Vitamin D to an animal are also described. Vitamin D and HMB are administered to increase muscle mass, strength, and functionality. The combination of Vitamin D and HMB together has a synergistic effect, which results in a surprising and unexpected level of improvement in muscle mass, strength and functionality.


The present invention provides a composition comprising HMB. Methods of administering HMB to an animal are also described. HMB is administered to decrease joint instability, increase joint stability, decrease joint stiffness, improve joint function, improve joint health, improve balanced movement and improve skeletal joint stability during muscle movement. HMB is administered to increase muscle strength and/or muscle mass in a side of the body contralateral to joint inflammation, joint damage, and/or joint injury.


The present invention provides a composition comprising HMB. Methods of administering HMB to an animal are also described. HMB is administered to enhance or promote lipolysis, increase adipocyte fat oxidation, induce adipocyte and muscle mitochondrial biogenesis, increase energy expenditure, decrease total body weight and increase body fat loss.


Grant
Agency: Department of Health and Human Services | Branch: National Institutes of Health | Program: SBIR | Phase: Phase II | Award Amount: 672.48K | Year: 2016

Approximately million Americans are affected by Alzheimer s disease AD and up to million will be affected by At present there is no preventive or curative treatment for AD or in age related cognitive decline and clinical trials of cognitive modifying compounds have not succeeded in identifying an effective treatment Despite a lot of efforts no candidates are available to slow down the development or even cure this devastating disease Although most of the efforts are focusing on the amyloid and the tau pathways we have taken a different approach and targeted oxidative stress Oxidative stress is a major pathogenic mechanism that underlies both the pre clinical development and subsequent progression of AD and one that could potentially be targeted preventively as well as therapeutically Levels of reactive oxygen species ROS increase during inflammation mitochondrial dysfunction and metal redox cycling catalyzed by A all processes associated with AD development ROS catalyzed lipid peroxidation generates bifunctional electrophiles BFEs We have shown that BFEs generated by oxidative stress accelerate A oligomerization generating oligomers that have similar neurotoxicity and immunoreactivity as the amyloid derived diffusible ligands They inhibit proteosomal activity cause mitochondrial dysfunction and promote dendritic cell activation of T cells Importantly we have shown that levels of BFE adducts on proteins are significantly elevated in hippocampus of AD post mortem human brains and correlate positively with both the CERAD plaque score and the Braak stage We have found that hydroxybenzylamine HOBA reacts fold faster with BFEs than lysine preventing protein modification in vitro and in vivo Importantly in hApoE transgenic mice HOBA inhibits all the effects of BFEs described above and prevents working memory deficit HOBA a natural product present in buckwheat seeds has been developed for use in humans by Metabolic Technologies Inc MTI Ames IA The chemical manufacturing and control data have been generated and pre clinical pharmacology and toxicology data are currently being collected In this project we propose to do single and multiple escalation dose studies necessary to characterize pharmacokinetics metabolism and safety of HOBA We also propose to establish brain penetrance of HOBA and to determine whether it reduces blood and CSF markers of oxidative modification of proteins Alzheimer s disease is the th cause of death for people over and over million Americans suffer from it If no treatment is developed to slow down or even cure the disease it is estimated that over million Americans will have AD by The goal of our proposed research is to perform human studies for a natural occurring small molecule that will be effective in arresting the progression of AD and could help target the mechanism of tissue injury that occurs at all stages of AD development and with of age related cognitive decline in healthy adults


Patent
Metabolic Technologies, Inc. | Date: 2015-09-22

The present invention provides a composition comprising HMB and Vitamin D. Methods of administering HMB and Vitamin D to an animal are also described. Vitamin D and HMB are administered to increase muscle mass, strength, and functionality. The combination of Vitamin D and HMB together has a synergistic effect, which results in a surprising and unexpected level of improvement in muscle mass, strength and functionality.


Grant
Agency: Department of Health and Human Services | Branch: National Institutes of Health | Program: SBIR | Phase: Phase II | Award Amount: 750.00K | Year: 2014

DESCRIPTION provided by applicant Sarcopenia defined as age related loss of muscle mass and muscle function and strength is very prevalent among the elderly Sarcopenia is one of the largest public health problems facing a rapidly increasing aging population in the United States and leads to increased incidence of falls fractures and associated morbidities Previous observations from our laboratory as well as from many other laboratories have demonstrated the efficacy of hydroxy methylbutyrate HMB alone or in combination with other amino acids in enhancing muscle strength and function in young athletes We have recently demonstrated that the combination of HMB with two other amino acids arginine and lysine was effective in increasing muscle mass in elderly men and women during a year long prospective study When analyzing the data Preliminary Results we demonstrated a close correlation between the levels of OH Vitamin D in this population and the level of improvement in muscle strength We noted that individuals with plasma OH Vitamin D levels andgt ng ml manifested muscle strength gains supplemented with HMB and two amino acids while those with plasma OH Vitamin D of andlt ng ml did not These data form the basis of our current hypothesis that the combination of HMB and Vitamin D supplementation will be synergistic and will result in significant enhancements in overall muscle strength function and muscle mass We propose these Phase I and Phase II studies to prove our hypothesis The Phase I study will test the short term wk efficacy of a combination of HMB and Vitamin D to prevent and reverse muscle sarcopenia and the associated losses of muscular strength and functionality in older adults We plan to recruit men and women who will be assigned to one of four dietary treatments Control HMB calcium salt g day IU Vitamin D and HMB g d IU Vitamin D The subjects will undergo a day per week exercise program and body composition and strength will be measured at four week intervals We expect to demonstrate the synergy between HMB and Vitamin D in this short study Phase II will test the long term mos efficacy of this synergistic combination of HMB and Vitamin D on the enhancement of muscle strength and functionality in the elderly thus leading to improved quality of life Phase II will include an exercise arm just like Phase I but will also include a non exercise arm because many elderly adults do not participate in an exercise program In addition to body composition and function and strength data muscle biopsies will be obtained and muscle fiber and proteomic analysis will be performed We anticipate that the data generated will lead to further research looking at mechanism s involved in loss of muscle and muscle function in the elderly Improvement in muscle strength and muscle function as well as improvements in body composition over the year long study will be used to market a product containing HMB and Vitamin D Current estimates place a large portion of the older U S populous at risk for falls with potential morbidities A large percentage of these falls are directly related to decreased muscle strength and function Since a significant portion of the older population is at risk of having a Vitamin D deficiency a product that corrects such deficiencies and specifically targets muscle strength function and mass is likely to produce significant improvements in health improve the quality of life and in particular help to decrease the incidence of falls and injury in this group Moreover based upon the incidence of widespread Vitamin D deficiency in all ages we anticipate the younger population will also benefit from similar supplementation


Patent
Metabolic Technologies, Inc. | Date: 2016-01-13

The present invention provides a composition comprising HMB and Vitamin D. Methods of administering HMB and Vitamin D to an animal are also described. Vitamin D and HMB are administered to increase muscle mass, strength, and functionality. The combination of Vitamin D and HMB together has a synergistic effect, which results in a surprising and unexpected level of improvement in muscle mass, strength and functionality.


Patent
Metabolic Technologies, Inc. | Date: 2015-09-29

The present invention provides a composition comprising HMB and Vitamin D. Methods of administering HMB and Vitamin D to an animal are also described. Vitamin D and HMB are administered to increase muscle mass, strength, and functionality. The combination of Vitamin D and HMB together has a synergistic effect, which results in a surprising and unexpected level of improvement in muscle mass, strength and functionality.

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