Agency: European Commission | Branch: FP7 | Program: CPCSA | Phase: ICT-2013.1.8 | Award Amount: 5.06M | Year: 2014
FrontierCities - European Cities driving the Future Internet (FrontierCities) is a proposal presented to the FI-PPP Phase 3 CP-CSA Call. The project builds on the FI-PPP Phase I and II work, and is directly linked to the work carried out in FI-Phase II use cases INSTANT MOBILITY, and OUTSMART. While building upon Phase II, FrontierCities is however in line with the significant change in focus required under Phase III, and represents an ambitious, market-focussed project. Core objectives are to solicit and select high-calibre grant applications from SMEs and webdevelopers through a mix of strategies and market the results to a pan-European audience of cities. The projects biggest work focus and resource allocation is on supporting grantee projects to secure market uptake and/or commercialisation of their technology applications and services to both cities and wider private sector uptakers and enablers (corporations, investors).The FrontierCities consortium has significant experience across the various stages of the grant cycle, and has consolidated annual income of more than 1.1 billion euros. In addition to targeting higher-potential cities w.r.t smart mobility uptake, it brings together an innovative dual approach of a pan-European focus in parallel with four local geographical focal points in B, I, SI, and UK. The consortiums innovation support has the capacity to deliver pan-European reach through the involvement of Europes largest innovation and commercialisation support network (EBN Network), combined with a range of local innovation actors and business enablers. A quality technology support dimension is ensured by three organisations previously involved in FI-PPP, including University of Surrey and Engineering SpA. Vertical Technology support (WP2) and Marketing (WP3) are included to ensure top quality support to grantees and to the market uptake work (WP6). A first set of impact indicators are set, which will be updated following the Call results.
Cuzzocrea S.,Messina University |
Esposito E.,Messina University
CNS and Neurological Disorders - Drug Targets | Year: 2013
The role of palmitoylethanolamide (PEA) in the regulation of complex systems involved in the inflammatory response, pruritus, neurogenic and neuropathic pain is well understood. Growing evidence indicates that this N-acylethanolamine also exerts neuroprotective effects within the central nervous system (CNS), i.e. in spinal cord and traumatic brain injuries and in age-related pathological processes. PEA is abundant in the CNS, and is produced by glial cells. Several studies show that administering PEA during the first few hours after injury significantly limits CNS damage, reduces loss of neuronal tissue and improves functional recovery. PEA appears to exert its protective effect by decreasing the development of cerebral edema, down-regulating the inflammatory cascade, and limiting cellular necrosis and apoptosis. All these are plausible mechanisms of neuroprotection. This review provides an overview of current knowledge of PEA effect on glial functions in the brain and how targeting glial-specific pathways might ultimately impact the development of therapies for clinical management of neurodegenerative disorders. The diverse signaling mechanisms are also summarized. © 2013 Bentham Science Publishers.
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2013.1.2 | Award Amount: 10.33M | Year: 2013
CloudWave will revolutionise modern cloud infrastructures and tools by enabling agile development and delivery of adaptive cloud services which dynamically adjust to changes in their environment so as to optimise service quality and resource utilization. In doing so, CloudWave will advance the competitiveness of the EU economy by providing a powerful foundation, based on open standards, for creating innovative cloud services, realising the full promise of cloud computing.\n\nCloudWave will tangibly deliver (1) an open architecture and standards-based reference implementation of an advanced cloud software stack, with novel capabilities for adaptation across all cloud layers; and (2) tools and methods for agile development of reliable and adaptable cloud services, facilitated by the new stack.\nTechnologically, CloudWave will advance the state-of-art along three dimensions:\n Execution Analytics: A new framework where specialised algorithms dynamically analyse cloud infrastructure and application behaviour, seamlessly integrate data pertaining to physical and virtual resources and IoT elements, and provide consolidated feedback to drive service evolution and adaptation\n Coordinated Adaptation: A new software technology where cloud services, cloud infrastructure and end-user devices exploit Execution Analytics to collaboratively and automatically undertake complex adaptation actions across the cloud stack, ensuring quality of service and effective utilization of ICT resources\n Feedback-Driven Development: A new agile approach for developing cloud applications, where developers exploit Execution Analytics to incrementally determine and evolve application features, extensions and optimizations, based on observed user needs.\n\nUsing two industry case studies, we will demonstrate how the CloudWave technology supports emerging cloud services and provides high and quantifiable improvements in service delivery quality, productivity, reliability and cost.
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: ICT-07-2014 | Award Amount: 3.57M | Year: 2015
Cloud federation enables cloud providers to collaborate and share their resources to create a large virtual pool of resources at multiple network locations. Different types of federation architectures for clouds and datacenters have been proposed and implemented (e.g. cloud bursting, cloud brokering or cloud aggregation) with different level of resource coupling and interoperation among the cloud resources, from loosely coupled, typically involving different administrative and legal domains, to tightly coupled federation, usually spanning multiple datacenters within an organization. In both situations, an effective, agile and secure federation of cloud networking resources is key to impact the deployment of federated applications. The main goal of this project is two-fold: research and develop techniques to federate cloud network resources, and to derive the integrated management cloud layer that enables an efficient and secure deployment of federated cloud applications. Our proposal will deliver a homogeneous virtualization layer, on top of heterogeneous underlying physical networks, computing and storage infrastructures, providing enablement for automated federation of applications across different clouds and datacenters. The project is fully committed to open source software. Cloud networking aspects will be based on OpenDaylight, a collaborative project under The Linux Foundation, and specifically we will leverage and extend the OpenDOVE project with new rich inter-cloud APIs to provision cross-site virtual networks overlays. The new inter-cloud network capabilities will be leveraged by existing open source cloud platforms, OpenNebula and OpenStack, to deploy multi-cloud applications. In particular, different aspects of the platforms will be extended to accommodate the federated cloud networking features like multi-tenancy, federated orchestration of networking, compute and storage management or the placement and elasticity of the multi-cloud applications.
Su D.S.,CAS Shenyang Institute of Metal Research |
Su D.S.,Fritz Haber Institute of the Max Planck Society |
Perathoner S.,Messina University |
Centi G.,Messina University
Chemical Reviews | Year: 2013
Nanocarbon is a term increasingly used to indicate the broad range of carbon materials having a tailored nanoscale dimension and functional properties that significantly depend on their nanoscale features. CNT and graphene belong to this class of materials comprising many more types of carbon materials, such as nanofibers, -coils, -diamonds, -horns, -onions, and fullerene. The field of application of nanocarbon materials is large, because they possess electrical and thermal conductivity, as well as a mechanical strength and lightness that conventional materials cannot match. With the diversity of their structure, these characteristic values can be achieved over an extremely wide range of conditions. For these reasons, they are extensively studied in applications going from photonics and optoelectronics to biotech and nanomedicine, advanced electrodes, and polymer composites. It should be mentioned that for commercial applications a comprehensive understanding of the catalyst structure, bonding, and properties is desirable, but not strictly necessary, provided that the catalysts are well-reproducible and give superior performances.
Agency: European Commission | Branch: FP7 | Program: MC-IAPP | Phase: FP7-PEOPLE-2012-IAPP | Award Amount: 920.56K | Year: 2013
The BIOFUR project consists of three partners. The SME Avantium Chemicals (AVT - NL), selected as one of the Cleantech top 100 companies in 2011 and the Centre National de la Recherche Scientifique (CNRS - FR) and the University of Messina (UNIME - IT), both leaders in their respective fields. This multi-sectorial research work will contribute to breakthrough knowledge on the catalytic furanic conversion fundamentals and will be necessary for a sustainable technological development of these novel polyester materials and fuels based on renewable resources. The project consist of three workpackages: WP1: Production, Characterization, Optimisation and Environmental Impact of the Production of Polyesters; WP2: Development of Nanostructured Catalysts to improve the Performances and Sustainability of the Catalytic Conversion and Upgrading of Furanics, and; WP3: Managerial, Interdisciplinarity, Intersectoral and Dissemination aspects. The BIOFUR project shows that the proposed knowledge transfer for the three host organizations through the secondment of their own staff and the recruitment of researchers from outside the partnership is very beneficial for the host organizations by significantly increasing their research quality and overall RTD capabilities and competitiveness. The proposed dissemination and outreach activities will make sure that also to the greater European community will benefit from this project. The Coordinator of the BIOFUR project is Dr. Ed de Jong of AVT and the other lead researchers are Prof. Gabriele Centi of UNIME and Prof. Nicolas Sbirrazzuoli of CNRS.
Centi G.,Messina University |
Quadrelli E.A.,School of Chemistry, Physics and Electronics, Lyon |
Perathoner S.,Messina University
Energy and Environmental Science | Year: 2013
Replacement of part of the fossil fuel consumption by renewable energy, in particular in the chemical industry, is a central strategy for resource and energy efficiency. This perspective will show that CO2 is the key molecule to proceed effectively in this direction. The routes, opportunities and barriers in increasing the share of renewable energy by using CO2 reaction and their impact on the chemical and energy value chains are discussed after introducing the general aspects of this topic evidencing the tight integration between the CO2 use and renewable energy insertion in the value chain of the process industry. The focus of this perspective article is on the catalytic aspects of the chemistries involved, with an analysis of the state-of-the-art, perspectives and targets to be developed. The reactions discussed are the production of short-chain olefins (ethylene, propylene) from CO2, and the conversion of carbon dioxide to syngas, formic acid, methanol and dimethyl ether, hydrocarbons via Fischer-Tropsch synthesis and methane. The relevance of availability, cost and environmental footprints of H2 production routes using renewable energies is addressed. The final part discusses the possible scenario for CO2 as an intermediary for the incorporation of renewable energy in the process industry, with a concise roadmap for catalysis needs and barriers to reach this goal. © 2013 The Royal Society of Chemistry.
Navarra M.,Messina University
Anti-cancer agents in medicinal chemistry | Year: 2014
Colorectal cancer (CRC) is a leading cause of cancer mortality in the industrialized world, second to lung cancer. A lot of evidences highlight that a diet rich in fruits and vegetables may reduce the risk of some types of cancer including CRC. In this study we demonstrate that Citrus bergamia juice extracts (BJe) reduces CRC cell growth by multiple mechanisms. Low BJe concentrations inhibit MAPKs pathway and alter apoptosis-related proteins, that in turn induce cell cycle arrest and apoptosis in HT-29 cells. Instead, high concentrations of BJe induce oxidative stress causing DNA damage. Our study highlights the role of BJe as modulator of cell apoptosis in CRC cells and strengthens our previous hypothesis that the flavonoid fraction of bergamot juice may play a role as anti-cancer drug.
Piccolo A.,Messina University
Applied Energy | Year: 2013
In this paper a simplified two-dimensional computational method for studying the entropy generation characteristics inside the core porous structures of a thermoacoustic refrigerator is presented. The model integrates the equations of the standard linear thermoacoustic theory into an energy balance-based numerical calculus scheme. The numerically computed spatial distributions of the time-averaged entropy generation rate within a channel of the stack and adjoining heat exchangers (HXs) evidence as the stack-HXs junctions act as strong sources of thermal irreversibility. The study also shows as, for a fixed refrigerating output level and temperature span, minimum in entropy generation can be effectively used as a suitable design criterion for optimizing simultaneously the stack length, the stack position and the plates interspacing. The same method, when applied to the optimization of the HXs, reveals that the length of the HXs along the direction of the acoustic vibration should be comprised between x1 (the amplitude of the acoustic displacement) and 2x1, the optimal value resulting an increasing function of the fin interspacing and of the drive ratio. © 2012 Elsevier Ltd.
Bruneo D.,Messina University
IEEE Transactions on Parallel and Distributed Systems | Year: 2014
Cloud data center management is a key problem due to the numerous and heterogeneous strategies that can be applied, ranging from the VM placement to the federation with other clouds. Performance evaluation of cloud computing infrastructures is required to predict and quantify the cost-benefit of a strategy portfolio and the corresponding quality of service (QoS) experienced by users. Such analyses are not feasible by simulation or on-the-field experimentation, due to the great number of parameters that have to be investigated. In this paper, we present an analytical model, based on stochastic reward nets (SRNs), that is both scalable to model systems composed of thousands of resources and flexible to represent different policies and cloud-specific strategies. Several performance metrics are defined and evaluated to analyze the behavior of a cloud data center: utilization, availability, waiting time, and responsiveness. A resiliency analysis is also provided to take into account load bursts. Finally, a general approach is presented that, starting from the concept of system capacity, can help system managers to opportunely set the data center parameters under different working conditions. © 2014 IEEE.