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Alcaraz J.,Hospital Mesa del Castillo | Oliver A.,Ruber Hospital | Sanchez J.M.,Hospital Mesa del Castillo
American Journal of Case Reports | Year: 2015

Objective: Unusual clinical course Background: The use of platelet-rich plasma is a now a common medical technique known as regenerative medicine, through power cell activation and differentiation, which produces growth factors called platelets derived both locally and systematically. Here, we report the case of a cerebral palsy patient who received intravenous platelet-rich plasma. Case Report: We administered an intravenous injection of concentrated platelet-rich plasma (25 cc) in a 6-year-old boy with perinatal cerebral palsy, cognitive impairment, and marked and severe generalized spasticity. We performed follow-up at 3 and 6 months after the injection. All serum samples for determination were obtained by ELISA technique. Cognitive scales (Bayley, Battelle, M.S.C.A, Kaufman ABC, and Stanford-Binet Intelligence scale) were used before and after treatment. The determination protocol that was applied before the analysis was performed manually and the autotransfusion was considered suitable for treatment. We determined the plasma levels of factor similar to insulin-1 (IGF-1), platelet-derived growth factor (PDGF), vasculo-endothelial growth factor (VEGF), and transforming growth factor B (TGF-B) before and during treatment monitoring. Conclusions: No adverse effects were observed in the patient except for a small hematoma in the area channeling venous access. We observed a clear improvement in the cognitive sphere (memory, ability to perform more complex tasks, and acquisition of new skills) and in language, maintaining stable levels of growth factor in plasma 3–5 times higher than average for his age group at both 3- and 6-month follow-up. Positron emission tomography (PET) images showed an evident increased demarcation in the cerebral cortex. We propose that this therapy is useful in these patients to harness the neurostimulative and neuroregenerative power of endogenous growth factors derived from platelets. © Am J Case Rep, 2015.


Ferrer Colomer M.,Hospital Mesa del Castillo | Pastor L.M.,Hospital Mesa del Castillo
Cuadernos de bioética : revista oficial de la Asociación Española de Bioética y Ética Médica | Year: 2012

This article is a study of the historical aspects that gave rise to the term 'preembryo'. We look at how the appearance of this term was related with attempts to justify ethical aspects associated with the destruction of embryos in the context of in vitro fecundation. The first scientific article found using this term was written by Clifford Grobstein in 1979 and not, as many people think, the Warnock report in 1984, although the term was used decisively in the British parliament between 1984 and 1990, culminating in the parliamentary approval of human embryos for research purposes. In the United States, the term was promoted by the Ethical Committee of the American Fertility Society in 1986. However, the term hardly appears in recent reports. In scientific and bioethical literature there has been a gradual decrease in the frequency with which it is used. It seems that the word 'preembryo' reflected a new metabiological concept coined to provide a basis for apparently scientific data in an attempt to avoid ethical aspects related with the destruction of human embryos in the absence of any unconditional respect towards the same. Once this goal had been achieved, the term was gradually abandoned.


Pablo Mesa Del-Castillo B.,University of Murcia | Rodiguez P.A.,University of Murcia | Blazquez A.,University of Murcia | Perez M.C.,University of Murcia | And 5 more authors.
Archives of Pediatric Infectious Diseases | Year: 2016

The current paper presents a three-year-old toddler with an acute and severe osteoarticular infection of her left hip and proximal thigh. In the first 24 hours she underwent an arthrotomy and during the intravenous phase of antibiotic treatment multiple teeth were removed because of an extensive periodontal disease. Streptococcus dysgalactiae subsp. equisimilis (SDSE) was identified in her blood culture samples. The paper discusses the clinical spectrum of the disease caused by this pathogen and briefly reviews the literature. To the authors’ best knowledge, this is the first case of septic osteomyelitis and arthritis caused by SDSE in a child. © 2016, Pediartric Infections Research Center.

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