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Tarsus, Turkey

Batmaz S.,Mersin State Hospital | Ozdel K.,Diskapi YB Training and Research Hospital | Kocbiyik S.,Ataturk Training and Research Hospital | Karadag H.,Diskapi YB Training and Research Hospital
Comprehensive Psychiatry | Year: 2014

Unipolar depression and bipolar depression differ in their clinical presentations, and the conventional depression rating scales fail to capture these differences. Recently, a new scale to rate the severity of depression in bipolar disorder was developed, and this study aims to evaluate the validity and reliability of this scale in a Turkish clinical sample. Methods: A total of 81 patients (30 males, 51 females) diagnosed with bipolar depression according to the DSM-IV-TR criteria at three different sites in Turkey were interviewed with the Bipolar Depression Rating Scale (BDRS), the Montgomery Asberg Depression Rating Scale, the Young Mania Rating Scale, and the Positive and Negative Syndrome Scale Depression and Excitement subscales. Internal consistency, interrater reliability and concurrent validity of the BDRS were evaluated. Results: The Turkish version of the BDRS had an acceptable internal consistency (Cronbach's alpha = 0.786). Moderate to strong correlations between the BDRS, and the MADRS (r = 0.808), and the PANSS-D (r = 0.426) were observed, and the BDRS correlated weakly to moderately with the PANSS-E (r = 0.297), and the YMRS (r = 0.368). The mixed symptom cluster score of the BDRS significantly correlated with the YMRS (r = 0.755), and the PANSS-E (r = 0.712). Exploratory factor analysis showed a three-factor solution. These factors corresponded to somatic depression, psychological depression, and mixed symptoms. Conclusions: This study shows that the Turkish version of the BDRS is a valid and reliable instrument to measure depressive symptomatology in bipolar disorder. The scale has good internal validity, strong interrater reliability, and moderate to strong correlations with other depression rating scales. © 2014 Elsevier Inc. All rights reserved.

Ozkan B.,Bucak State Hospital | Arik O.Z.,Gumushane State Hospital | Gozukara M.Y.,Mersin State Hospital | Sahin D.Y.,Adana Numune Training and Research Hospital | And 6 more authors.
Blood Coagulation and Fibrinolysis | Year: 2016

Stroke is the leading cause of disability worldwide. It is known that atrial fibrillation and left atrial enlargement contribute ischemic stroke, and mean platelet volume (MPV) increases in patients with ischemic stroke and atrial fibrillation. We aimed to determine whether higher MPV is associated with ischemic stroke in patients with sinus rhythm. We evaluated 74 patients in sinus rhythm and with ischemic stroke (Group 1) and 90 age-matched and sex-matched healthy individuals as control group (Group 2). After physical and echocardiographic examination, 24-48 h Holter monitoring and complete blood counts were studied. There were no statistically significant differences in age, sex rates, and comorbidities between groups. Left atrial diameter was higher in Group 1 than Group 2 (P = 0.001), but both were in normal range. MPV was significantly higher in Group 1 (P < 0.001) and was an independent determinant [odds ratio (OR): 1.840; P < 0.001; 95% confidence interval (CI) 1.330-2.545] of ischemic stroke with left atrial (OR: 1.138; P = 0.006; 95% CI 1.037-1.248). In conclusion, higher MPV is associated with acute ischemic stroke in patients with sinus rhythm and without heart failure or left atrial enlargement. MPV and left atrial diameter are independent predictors of ischemic stroke in this patient population. © 2016 Wolters Kluwer Health, Inc. All rights reserved.

Gozukara Y.M.,Mersin State Hospital | Akalan G.,Mersin University | Tok E.C.,Mersin University | Aytan H.,Mersin University | Ertunc D.,Mersin University
International Urogynecology Journal and Pelvic Floor Dysfunction | Year: 2014

Introduction and hypothesis: It has been suggested that weight reduction decreases the frequency of urinary incontinence (UI) episodes. However, it is not known if this improvement is associated with anatomical changes in the pelvis. The aim of this study was to investigate the effects of weight loss on UI episodes and pelvic floor anatomy. Methods: Three hundred seventy-eight overweight/obese women were randomly allocated either to behavioral weight loss or to structured education programs. The patients were evaluated by voiding diary, Pelvic Floor Distress Inventory (PFDI), and Pelvic Organ Prolapse Quantification (POP-Q) system at baseline and after 6 months. Results: The women in the intervention group had a mean weight loss of 9.4 %, whereas the weight in the control group remained almost the same (P<0.001). While there were no change in stress and urge incontinence episodes in the control group, the mean number of stress incontinence episodes per 3-day diary dropped from 7.96 episodes to 3.11, and the mean number of urge incontinence episodes per 3-day diary dropped from 2.85 episodes to 1.08 in the study group (P<0.05). Regarding the POP-Q system, only genital hiatus, perineal body, and Ap measurements were significantly lower in the weight loss group than in the control group after 6 months. Conclusions: Weight reduction provides improvement in episodes of UI, decreases the incidence of drops of urine leakage, and increases quality of life related to pelvic floor symptoms. However, there are little to no changes in the parameters of the POP-Q system with weight reduction. © 2014 The International Urogynecological Association.

Rheumatoid pleural effusion and lung nodules are unusual complications of rheumatoid disease that typically present subsequently to other more common manifestations of rheumatoid illness. However, these complications may occasionally occur before or concurrently with the development of joint manifestations of disease. We report the case of a 41-year-old female patient with rheumatoid pleural effusion and lung nodule arising simultaneously with the onset of joint symptoms. The patient underwent thoracentesis followed by video-assisted thoracoscopic biopsy to result in a diagnosis of rheumatoid pleuritis and nodular disease. A high index of suspicion and coexistence of the cytologic and histopathologic effusion picture characteristic of rheumatoid pleuritis are of clinical importance in making a diagnosis. © 2014, Springer-Verlag Berlin Heidelberg.

Yaman E.,Mersin State Hospital | Coskun U.,Gazi University | Sancak B.,Gazi University | Buyukberber S.,Gazi University | And 2 more authors.
International Immunopharmacology | Year: 2010

Background: Cytokeratin 18 (CK-18) is a cytoskeleton protein of epithelial cells which are released into the circulation during necrotic or apoptotic cell death. M30 detects caspase-cleaved neo-epitope of CK-18; whereas M 65 measures whole length intact protein. We aimed to evaluate the prognostic significance of serum M65 and M30 levels in patients with gastric carcinoma. Methods: Thirty eight patients with advanced disease were included in the study. Thirty-two healthy people were chosen as control group. Serum M65 and M30 levels were measured by quantitative ELISA method. Results: Serum M65 levels were found significantly elevated in patients compared to control group (385.7 ± 280.6 vs. 200.2 ± 164.5, p = 0.002). Serum M30 levels were significantly increased in patients compared to the control group (204.6 ± 245 vs. 106.5 ± 17.5, p = 0.03). Patients with metastatic disease had significantly higher levels of serum M30 compared to patients with locally advanced disease (267.1 ± 296.1 vs. 102.3 ± 53.2, p = 0.03). Serum M30 and M65 levels were evaluated in respect to survival. Best cut-off value for the prediction of death for M30 antigen level was 83.8 U/L. Patients with higher M30 levels had significantly shorter median survival compared to patients' lower serum M30 levels. However, there was no impact of serum M65 levels on survival. Serum M30 levels and clinical stage were found as the strongest variables with independent prognostic value for overall survival. Discussion: These results suggest that serum M65 and M30 levels were elevated in patients with advanced gastric carcinoma patients. Serum M30 levels can be helpful to predict tumor load and also survival. © 2010 Elsevier B.V. All rights reserved.

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