Cambridge, MA, United States
Cambridge, MA, United States

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Patent
Mersana Therapeutics | Date: 2016-11-04

This invention provides fully human monoclonal antibodies that recognize HER2. The invention further provides methods of using such monoclonal antibodies in a variety of therapeutic, diagnostic, and prophylactic indications.


Patent
Mersana Therapeutics | Date: 2015-06-18

A polymeric scaffold useful for conjugating with a protein based recognition-molecule (PBRM) to form a PBRM-polymer-drug conjugate is described herein. The scaffold includes one or more terminal maleimido groups. Also disclosed is a PBRM-polymer-drug conjugate prepared from the scaffold. Compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders, such as cancer in a subject having low HER2 expression with the conjugates or their compositions are also described.


Patent
Mersana Therapeutics | Date: 2015-06-18

This invention provides fully human monoclonal antibodies that recognize HER2. The invention further provides methods of using such monoclonal antibodies in a variety of therapeutic, diagnostic, and prophylactic indications.


Patent
Mersana Therapeutics | Date: 2014-08-12

Auristatin compounds and conjugates thereof are provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L^(D)-D, the protein based recognition-molecule being connected to the polymeric carrier by L^(P). Each occurrence of D is independently an Auristatin compound. L^(D )and L^(P )are linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.


Patent
Mersana Therapeutics | Date: 2014-08-12

A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L^(D)-D, the protein based recognition-molecule being connected to the polymeric carrier by L^(P). Each occurrence of D is independently a therapeutic agent having a molecular weight 5 kDa. L^(D )and L^(P )are linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.


Patent
Mersana Therapeutics | Date: 2014-10-10

A polymeric scaffold useful for conjugating with a protein based recognition-molecule (PBRM) to form a PBRM-polymer-drug conjugate is described herein. The scaffold includes one or more terminal maleimido groups. Also disclosed is a PBRM-polymer-drug conjugate prepared from the scaffold. Compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions are also described.


Patent
Mersana Therapeutics | Date: 2015-08-24

A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L^(D)-D, the protein based recognition-molecule being connected to the polymeric carrier by L^(P). Each occurrence of D is independently a therapeutic agent having a molecular weight 5 kDa. L^(D )and L^(P )are linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.


Patent
Mersana Therapeutics | Date: 2016-01-19

Auristatin compounds and conjugates thereof are provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L^(D)-D, the protein based recognition-molecule being connected to the polymeric carrier by L^(P). Each occurrence of D is independently an Auristatin compound. L^(D )and L^(P )are linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.


Patent
Mersana Therapeutics | Date: 2014-01-16

A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L^(D)-D, the protein based recognition-molecule being connected to the polymeric carrier by L^(P). Each occurrence of D is independently a therapeutic agent having a molecular weight 5 kDa. L^(D )and L^(P )are linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.


Patent
Mersana Therapeutics | Date: 2014-03-13

A tubulysin compound conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L^(D)-D, the protein based recognition-molecule being connected to the polymeric carrier by L^(P). Each occurrence of D is independently a tubulysin compound having a molecular weight5 kDa. L^(D )and L^(P )are distinct linkers connecting the tubulysin compound and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-tubulysin compound-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.

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