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Chestnut Ridge, MA, United States

Theile C.S.,Merkert Chemistry Center | McLaughlin L.W.,Merkert Chemistry Center
Chemical Communications | Year: 2012

Here we present new routes for the efficient syntheses of 6,5′-(S)- and 6,5′-(R)-cyclouridine. The syntheses utilize readily accessible uridine as a starting material. This route to the R diastereomer is significantly more efficient than previous synthetic efforts, allowing us to obtain large amounts of pure material for future biological testing. © 2012 The Royal Society of Chemistry.

Couvertier S.M.,Merkert Chemistry Center | Weerapana E.,Merkert Chemistry Center
MedChemComm | Year: 2014

We utilized tri-functionalized 4-aminopiperidine as a modular scaffold to generate a cysteine-reactive probe library. Using in-gel fluorescence screening against lysates overexpressing glutathione S-transferase omega 1 (GSTO1) and the protein kinase AKT1, we identified SMC-1 and SMC-8 as activity-dependent covalent modifiers of these enzymes. These compounds are ideal chemical probes to monitor enzyme activity in proteomes. © 2014 The Royal Society of Chemistry.

Zhou S.,Merkert Chemistry Center | Yang X.,Merkert Chemistry Center | Xie J.,Merkert Chemistry Center | Simpson Z.I.,Merkert Chemistry Center | Wang D.,Merkert Chemistry Center
Chemical Communications | Year: 2013

Compared with competing technologies, rechargeable lithium ion batteries offer relative advantages such as high capacity and long cycle lifetime. Remarkable advances in the development of this technology notwithstanding significant performance improvements are still required to meet society's ever-growing electrical energy storage need. In particular, we long for devices with greater capacity, a higher power rate and a longer cycle lifetime. Aimed at solving challenges associated with poor charge transport within electrode materials, we have recently tested a new, nanonet-based material platform. The nanonet, made of TiSi2 (C49), is similar to the more commonly used porous carbon in that it has high surface area and good electrical conductivity. The key uniqueness of the nanonet lies in that its morphology is well-defined, permitting us to design and test various heteronanostructures. In essence, the TiSi2 nanonet can serve as a charge collector and a mechanical support for the construction of electrodes for a wide range of applications. We show that when combined with Si, an anode with superior performance is obtained. Similarly, a high-performance cathode is enabled by the TiSi2-V 2O5 combination. This journal is © 2013 The Royal Society of Chemistry.

Lin Y.,Merkert Chemistry Center | Yuan G.,Merkert Chemistry Center | Sheehan S.,Merkert Chemistry Center | Zhou S.,Merkert Chemistry Center | Wang D.,Merkert Chemistry Center
Energy and Environmental Science | Year: 2011

As the most commonly encountered form of iron oxide in nature, hematite is a semiconducting crystal with an almost ideal bandgap for solar water splitting. Compelled by this unique property and other advantages, including its abundance in the Earth's crust and its stability under harsh chemical conditions, researchers have studied hematite for several decades. In this perspective, we provide a concise overview of the challenges that have prevented us from actualizing the full potentials of this promising material. Particular attention is paid to the importance of efficient charge transport, the successful realization of which is expected to result in reduced charge recombination and increased quantum efficiencies. We also present a general strategy of forming heteronanostructures to help meet the charge transport challenge. The strategy is introduced within the context of two material platforms, webbed nanonets and vertically aligned transparent conductive nanotubes. Time-resolved photoconductivity measurements verify the hypothesis that the addition of conductive components indeed increases charge lifetimes. Because the heteronanostructure approach is highly versatile, it has the potential to address other issues of hematite as well and promises new opportunities for the development of efficient energy conversion using this inexpensive and stable material. © The Royal Society of Chemistry 2011.

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