Mercian Corporation

Fujisawa, Japan

Mercian Corporation

Fujisawa, Japan
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A method for manufacturing grape juice in which muscat aroma is emphasized is disclosed. The method comprises step (a) and step (b), or comprises step (a), step (b) and step (c): (a) obtaining fruit skin or fruit skin-containing fruit juice by crushing and squeezing grape berries; (b) heating a material formed by adding water to the fruit skin obtained in step (a) or the fruit skin-containing fruit juice obtained in step (a), wherein the temperature of the material or the fruit juice is elevated to reach 45C to 95C to form a mixture; (c) air-cooling the mixture obtained in step (b) and subsequently adding an enzyme having a glycosidase activity for diglycoside to the mixture. By using grape juice which is manufactured according to this method as a raw material, wine having rich muscat aroma can be manufactured.


Patent
Mercian Corporation and Sichuan Xieli Pharmaceutical Co. | Date: 2011-02-02

The invention offers a method of hydrogenating camptothecin in inert solvent in the presence of nickel catalyst, whereby selective hydrogenation of camptothecin can be very efficiently accomplished using the low-cost catalyst.


Patent
Mercian Corporation and Eisai R&D Management Co. | Date: 2011-03-09

The present invention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide compound represented by the following formula obtained from the incubation solution of Streptomyces sp. Mer. 11107 or a variant thereof, a pharmacologically acceptable salt thereof or a hydrate of them, and a process for producing it.


Patent
Mercian Corporation, Japan National Institute of Advanced Industrial Science and Technology | Date: 2011-08-17

A vitamin D_(3) hydroxylase is purified from Pseudonocardia autotrophica cell, and a primer is designed based on amino acid sequence obtained from hydroxylase. Subsequently, PCR is conducted using genomic DNA of Pseudonocardia autotrophica as a template to clone a gene for the vitamin D_(3) hydroxylase. By conducting a conversion reaction using a microorganism in which the vitamin D_(3) hydroxylase gene is expressed using a proper expression system, a hydroxide of vitamin D or the like (e.g., hydroxy vitamin D_(3)) can be produced with high efficiency.


Patent
Mercian Corporation, Japan National Institute of Advanced Industrial Science and Technology | Date: 2011-07-06

An expression vector capable of expressing a foreign gene in Pseudonocardia autotrophica; a transformant of Pseudonocardia autotrophica produced by using the expression vector; a method for producing a protein by using the transformant; a method for producing an active form of vitamin D3 from vitamin D3, which comprises highly expressing a gene encoding an enzyme involved in the synthesis of the active form of vitamin D3 in a transformant by using the expression vector or the transformant; a method for producing 25-hydroxyvitamin D2 from vitamin D2; and a method for producing pravastatin from compactin, which comprises highly expressing a compact in hydroxylase gene in a transformant by using the expression vector or the transformant.


A method is disclosed for manufacturing fruit liquor in which muscat fragrance is emphasized. The method includes either or both of set of step (a) and step (d) and another set of step (b) and step (c). Step (a) is to obtain fruit juice or fruit juice containing pericarp, by crushing and squeezing the fruit part of grapes. Step (b) is to heat the fruit juice or the fruit juice containing pericarp obtained in step (a) so as to make the article temperature reach 45 to 95 C. Step (c) is to add enzyme having the glycosidase activity at the article temperature of fruit juice in a range of 10 to 55 C. Step (d) is to ferment the fruit juice obtained in step (b) or step (c) using a yeast having the -glucosidase activity. The fruit liquor manufactured by this method has favorable muscat fragrance.


The present invention relates to a method of production of a solution containing an abundance of 3-mercaptohexan-1-ol (3MH) and alcohol and having a desirable aroma by employing a grape skin extract; an aromatic agent employing the 3MH and alcohol containing solution; a method of production of a drink with an enhanced aroma; and a method of production of fruit liquor, employing a grape skin extract. The method of production of the 3MH and alcohol containing comprising: inoculating a starting material aqueous solution comprising S-(3-hexan-1-ol)glutathione and S-(3-hexan-1-ol)-L-cysteine with a lactic acid bacterium and yeast to produce 3-mercaptohexan-1-ol and alcohol. The starting material aqueous solution comprises a grape skin extract. The lactic acid bacterium is a lactic acid bacterium that is capable of converting S-(3-hexan-1-ol)glutathione to S-(3-hexan-1-ol)-L-cysteine. After inoculating the starting material aqueous solution with a lactic acid bacterium and conducting fermentation for 0 to 6 days, the aqueous solution is inoculated with the yeast and alcohol fermentation is conducted.


Patent
Mercian Corporation | Date: 2011-10-19

The disclosed are a soft drink having both an excellent fruity aroma and a fruity afteraroma once swallowed, and a method for manufacturing the same. The further disclosed are a grape skin extract, rich in precursors of 3-mercaptohexan-1-ol having good aroma, for use in manufacturing the soft drink, and to a method of preparation of the same.


Patent
Mercian Corporation and Eisai R&D Management Co. | Date: 2010-12-29

The present invention relates to a compound represented by the formula (I):^(3), R^(6), R^(7) and R^(21) are the same as or different from one another and each represents a hydroxyl group etc.), a pharmacologically acceptable salt thereof or a hydrate of them. The compound (I) of the present invention suppresses angiogenesis, in particular, suppresses VEGF production in a hypoxic condition and is useful as a therapeutic agent for treating solid cancer.


Patent
Eisai R&D Management Co. and Mercian Corporation | Date: 2011-05-04

The nucleotide sequence of a DNA involved in the biosynthesis of herboxidiene was determined. Utilizing this DNA, herboxidiene and analogues thereof can be efficiently produced.

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