Menufia, Egypt
Menufia, Egypt

Menoufia University is located in Al Minufya, Egypt. It was founded in 1976. Wikipedia.

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Maher M.A.,Menoufia University
Obstetrics and Gynecology | Year: 2017

OBJECTIVE:: To compare sildenafil plus hydration with hydration alone in improving the amniotic fluid index and neonatal outcomes in pregnancies complicated by idiopathic oligohydramnios ( amniotic fluid index less than 5 cm without underlying maternal or fetal causes and with normal fetal growth). METHODS:: This was an open-label randomized trial for women carrying singleton pregnancies at 30 weeks of gestation or more with idiopathic oligohydramnios detected during routine ultrasonogram. Women received either oral sildenafil citrate (25 mg every 8 hours) plus intravenous infusion of 2 L isotonic solution or fluids only until delivery. The primary study outcome was the amniotic fluid volume at 6 weeks of follow-up or the final volume before delivery, whichever occurred first. Secondary outcomes were duration of pregnancy prolongation, mode of delivery, and select neonatal outcomes. The study was powered to detect a 45% difference between groups, so, at an α level of 0.05 and 80% power, a sample size of 167 women was required. RESULTS:: From February 24, 2015, through April 2016, 196 women were screened and 184 were randomized. Follow-up was completed in 166 (90%): 82 in the sildenafil group and 84 in the hydration group. Baseline characteristics were similar between groups. The amniotic fluid volume was higher in the sildenafil group at the final assessment (11.5 compared with 5.4 cm, P=.02). The sildenafil group delivered later (38.3 compared with 36.0 weeks of gestation, P=.001), had a lower rate of cesarean delivery (28% compared with 73%), and their neonates were less likely to be admitted to the neonatal intensive care unit (11% compared with 41%, P=.001). CONCLUSION:: Sildenafil citrate increases amniotic fluid volume in pregnancies complicated by oligohydramnios. CLINICAL TRIAL REGISTRATION::,, NCT02372487. © 2017 by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved.

Background:Transarterial chemo-embolisation (TACE) is recommended for patients with BCLC intermediate stage hepatocellular carcinoma (stage B), particularly in patients with good underlying liver function and minimal symptoms. The hepatoma arterial embolisation prognostic (HAP) score combines measures of liver function and tumour-related factors to offer a simple prognostic scoring system. The Albumin-Bilirubin (ALBI) grade permits assessment of the impact of liver function on survival. We aimed to investigate these two models and vascular invasion (VI).Methods:In an international cohort of 3030 patients undergoing TACE, we examined the impact of liver function as assessed by the ALBI score, the HAP score and VI on survival.Results:Classification according to ALBI grade resulted in non-overlapping survival curves in the overall data set and all regional cohorts. The HAP score was also validated. Tumour number, aetiology and VI were identified as additional independent prognostic risk factors not currently included in the HAP score. Survival was particularly poor for patients with VI.Conclusions:The ALBI grade categorised patients receiving TACE into three clear prognostic groups, thereby emphasising the importance of underlying liver function in the outcome of TACE. The HAP score has been validated internationally and the serious adverse impact of VI is clearly shown.British Journal of Cancer advance online publication, 26 January 2017; doi:10.1038/bjc.2016.423 © 2017 The Author(s)

Agency: European Commission | Branch: FP7 | Program: CP-FP-SICA | Phase: HEALTH.2010.1.2-4 | Award Amount: 3.85M | Year: 2010

Chronic hepatitis C is one of the most common chronic viral infections of humans and a major cause of chronic liver disease, cirrhosis and liver cancer. Still about 4 million new infections occur world-wide each year with 50-85% of patients progressing to chronic hepatitis C. Currently there is no marker to predict spontaneous viral clearance and to guide treatment decisions. The major objectives of the HepaCute proposal are to develop biomarkers predicting the outcome of acute hepatitis C, improving the management of the related patients and thus decreasing the health burden of hepatitis C in Europe and Mediterranean partner countries (MPC). The HepaCute consortium has evolved from a series of EC-funded projects on hepatitis C (HCVacc/HepCvax/Virgil/HEPACIVAC) and consists of world leading experts in HCV epidemiology, immunology, and virology, including partners from Egypt and Morocco, who have strongly influenced the current management of patients with acute hepatitis C in their respective regions, and contributed considerably to our understanding of mechanisms of spontaneous viral clearance. The HepaCute proposal is closely connected to ongoing national, European, and Egyptian networks on HCV research (HepNet, EASL, STDF), which will support HepaCute to make it a success.Together with another pertinent EU-funded research project, SPHINX, it actively contributes to coordinating EU-funded hepatitis C research with pertinent research projects funded in the MCP countries, in particular with hepatitis research projects funded under the Egyptian Science and Technology Development Fund (STDF). Within HepaCute the most innovative technologies will be employed such as genome-wide association studies, transcriptomics, proteomics, and ultra-deep sequencing to better understand the early events in acute hepatitis C and to translate these results into readily practicable diagnostic tools to predict spontaneous viral clearance. HepaCute has firmly integrated partners from Egypt and Morocco with preexisting research collaborations with European partners into the scientific research programm and we expect this continuing partnership between European and Mediterranean countries to have a strong impact on the care of patients with acute hepatitis C both in Europe and MPC.

Hameed I.A.,Menoufia University
Expert Systems with Applications | Year: 2011

In this paper, a more reliable system of student evaluation based on gaussian membership functions will be introduced. The proposed method is modeled as a three fuzzy nodes system. Each of the three nodes applies fuzzification, fuzzy inference, and defuzzification in considering the difficulty, importance and complexity of questions. The first node computes the difficulty of questions as a function of the fuzzified average accuracy and average time rates of questions. The second node computes the cost of answering questions as a function of its difficulty and complexity. The third node computes the degree of adjustment required by questions as a function of its answer-cost and importance. The accuracy and answer-time rates of questions are obtained from students' answerscripts while the complexity and importance of questions are obtained by a domain expert, i.e.; teachers and/or examiners. In order to improve the reliability and robustness of the system, Gaussian membership functions (MFs) are proposed as an alternative to the traditional triangular MFs. © 2010 Elsevier Ltd. All rights reserved.

El-Hefnawy N.A.,Menoufia University
International Journal of Artificial Intelligence | Year: 2014

The bi-level programming problem (BLPP) is considered to be NP-hard problem. This paper suggests a modified particle swarm optimizer (MPSO) for solving fuzzy bi-level single and multiobjective problems. In this approach the BLPP handles as fuzzy multi-objective problem. Most traditional algorithms designed for specific versions or based on specific assumptions in the BLPP, thus it is difficult to improve the diversity and expand the search space of the particle. For such problems, new strategy for the adaptive inertia weight in PSO is proposed to control the domain of the particle oscillation according to fitness function, and to eliminate the need for velocity clamping. In addition, fuzzy utility membership function introduced to extract the best compromise solution based on fuzzy set theory. Finally, simulation results will be presented for six test problems and compare them with other algorithms to illustrate the efficiency of the proposed algorithm. © 2014 by IJAI (CESER PUBLICATIONS).

Hossny A.,Menoufia University
Journal of Vascular Surgery | Year: 2014

Objective One complication of autogenous arteriovenous fistula (AVF) for hemodialysis is the formation of a venous aneurysm (VA). The treatment of massive aneurysmal AVF generally involves ligation or resection with the use of prosthetic interposition. Partial aneurysmectomy, with or without reduction venoplasty, has been suggested to treat such a complicated AVF to maintain an all-autogenous access. The purpose of this study was to describe these procedures and examine their outcomes. Methods From January 2008 to May 2012, 14 patients (64% males) with complicated VAs were treated by partial aneurysmectomy with reduction venoplasty for a diffusely dilated venous segment. Patients with an infected aneurysm or central vein stenosis were not included. The surgical technique and the postoperative outcome were described. Results Patients were a mean age of 37.2 ± 12.2 years. Twenty-five aneurysms and four diffusely dilated segments (7, 10, 15, and 21 cm in length) were treated. Four patients (29%) presented with one aneurysm, nine (64%) with two aneurysms, and one (7%) with three aneurysms. The main clinical indications for intervention were skin necrosis and erosion with imminent danger of bleeding in nine (64%), stenosis related to aneurysm in one (7%), and high flow associated with multiple aneurysms or massive diffuse venous dilatation in four (29%). The AVFs were a mean age of 42.4 ± 8.8 months and the VAs were a mean age of 16.2 ± 4.2 months at the time of partial aneurysmectomy. The mean aneurysm diameter was 5.3 ± 1.6 cm. The procedures were successful in all patients. The mean operative time was 180.3 ± 51.5 minutes (range, 90-245 minutes), and the mean hospital stay was 2.5 ± 1.2 days. In five patients, a sufficient usable portion of the AVF remained for cannulation and was punctured the day after the procedure; in the remaining nine patients, a tunneled hemodialysis catheter was inserted. The AVFs remained patent, without recurrent aneurysms, and were used continuously for dialysis throughout the follow-up periods, which were a mean of 30.4 ± 14.4 months (range, 6-48 months). Two patients with functioning AVFs died of causes that were not related to the aneurysmectomy procedure. Conclusions Partial aneurysmectomy is a simple and effective intervention for managing aneurysm-associated complications. It offers the ability to maintain the benefits of an autogenous access while conserving future dialysis sites. Partial aneurysmectomy is recommended as a first-line choice for managing aneurysm-associated complications. © 2014 by the Society for Vascular Surgery.

Allama A.M.,Menoufia University
Annals of Thoracic Surgery | Year: 2010

Background: Intercostal nerve damage is often suggested to be the cause of pain after thoracotomy. Methods: This was a prospective randomized study of 120 patients who had posterolateral thoracotomy. They were equally divided into two groups, the first in which intercostal muscle flap and intracostal sutures were used, and the other group in which the usual pericostal sutures were used. These two groups were compared regarding operative time, rib fracture, postoperative pulmonary functions, time to ambulation, pain score in the first week, doses of analgesics injected in the epidural catheter, postoperative complications, chest tube drainage, hospital stay, return to daily activities, and pain score and use of analgesics at 1, 3, and 6 months. Results: Postoperative pain score throughout the first week was significantly lower in the patients in the intercostal muscle flap group, who had also a significantly earlier postoperative ambulation and return to normal daily activities, and received significantly lower doses of postoperative analgesics. After 1 month, patients in the intercostal muscle flap group had a significantly lower pain score and use of analgesics. After 3 months, pain score was not significantly different between both groups, but the use of analgesics was significantly lower in the intercostal muscle flap group. After 6 months, no significant difference was present between both groups with regard to pain score or the use of analgesics. Conclusions: Intercostals muscle flap and intracostal sutures are rapid, safe, and effective procedures in decreasing early pain after thoracotomy with subsequent earlier return to normal daily activities and lesser use of analgesics. © 2010 The Society of Thoracic Surgeons.

El-Boraey H.A.,Menoufia University
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2012

Novel eight Co(II), Ni(II), Cu(II), Cu(I) and Pd(II) complexes with [N 4] ligand (L) i.e. 2-amino-N-{2-[(2-aminobenzoyl)amino]ethyl} benzamide have been synthesized and structurally characterized by elemental analysis, spectral, thermal (TG/DTG), magnetic, and molar conductivity measurements. On the basis of IR, mass, electronic and EPR spectral studies an octahedral geometry has been proposed for Co(II), Ni(II) complexes and Cu(II) chloride complex, square-pyramidal for Cu(I) bromide complex. For Cu(II) nitrate complex (6), Pd(II) complex (8) square planar geometry was proposed. The EPR data of Cu(II) complexes in powdered form indicate dx2-y2 ground state of Cu(II) ion. The antitumor activity of the synthesized ligand and some selected metal complexes has been studied. The palladium(II) complex (8) was found to display cytotoxicity (IC50 = 25.6 and 41 μM) against human breast cancer cell line MCF-7 and human hepatocarcinoma HEPG2 cell line. © 2012 Elsevier B.V. All rights reserved.

Amer K.H.,Menoufia University
Agricultural Water Management | Year: 2010

Non-uniformity of water distribution under irrigation system creates both deficit and surplus irrigation areas. Water salinity can be hazard on crop production; however, there is little information on the interaction of irrigation and salinity conditions on corn (Zea Mays) growth and production. This study evaluated the effect of salinity and irrigation levels on growth and yield of corn grown in the arid area of Egypt. A field experiment was conducted using corn grown in northern Egypt at Quesina, Menofia in 2009 summer season to evaluate amount of water applied, salinity hazard and their interactions. Three salinity levels and five irrigation treatments were arranged in a randomized split-plot design with salinity treatments as main plots and irrigation rates within salinity treatments. Salinity treatments were to apply fresh water (0.89dSm-1), saline water (4.73dSm-1), or mixing fresh plus saline water (2.81dSm-1). Irrigation treatments were a ratio of crop evapotranspiration (ET) as: 0.6ET, 0.8ET, 1.0ET, 1.2ET, and 1.4ET. In well-watered conditions (1.0ET), seasonal water usable by corn was 453, 423, and 380mm for 0.89EC, 2.81EC and 4.73EC over the 122-day growing season, respectively. Soil salt accumulation was significantly increased by either irrigation salinity increase or amount decrease. But, soil infiltration was significantly decreased by either salinity level or its interaction with irrigation amount. Leaf temperature, transpiration rate, and stomata resistance were significantly affected by both irrigation and salinity levels with interaction. Leaf area index, harvest index, and yield were the greatest when fresh and adequate irrigation was applied. Grain yield was significantly affected in a linear relationship (r2≥0.95) by either irrigation or salinity conditions with no interaction. An optimal irrigation scheduling was statistically developed based on crop response for a given salinity level to extrapolate data from the small experiment (uniform condition) to big field (non-uniformity condition) under the experiment constraints. © 2010 Elsevier B.V.

Zaky M.S.,Menoufia University
IEEE Transactions on Industrial Electronics | Year: 2012

This paper presents an analysis by which the stability of a multiple-input-multiple-output system of simultaneous speed and stator resistance estimators for sensorless induction motor drives can be successfully predicted. The instability problem of an adaptive flux observer (AFO) is deeply investigated. In order to achieve stability over a wide range of operation, a design of the observer feedback gain is proposed. Furthermore, closed-loop control systems of the independent use of the two estimators are developed. Therefore, all gains of the adaptive proportional-integral controllers are selected and generalized to provide good tracking performance as well as fast dynamic response. The performance of the AFO using the proposed gains, with a sensorless indirect-field-oriented-controlled induction motor drive, is verified by simulation and experimental results. The results show a good improvement in both convergence and stability, particularly in the regenerative mode at low speeds, which confirm the validity of the proposed analysis. © 2011 IEEE.

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