Okazaki, Japan
Okazaki, Japan

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The present invention describes the identification of two single nucleotide polymoiphisms (SNPs) within the SRBD1 gene, which are associated with canine glaucoma. The invention relates to these SNP markers and the use thereof for the diagnosis of glaucoma across and within dog breeds. The invention also relates to a method of diagnosing glaucoma in dogs or of identifying dogs at risk of developing glaucoma, which comprises detecting the identity, presence or absence of at least one of the described SNPs. Reagents and kits useful for carrying out the diagnosis method are also provided.


A decentered type contact lens including: an optical zone provided in a center part of the contact lens; a peripheral zone provided on an outer circumference of the optical zone; an optical center of the optical zone being set to deviate from a lens geometric center; and a circumferential direction alignment mechanism for setting a lens circumferential direction position in a worn state, the contact lens being characterized in that: a center-of-gravity deviation in relation to the lens geometric center is set for the peripheral zone, and a center-of-gravity position shift accompanying deviation of the optical center of the optical zone in relation to the lens geometric center is corrected by offset using the center-of-gravity deviation of the peripheral zone.


Patent
Menicon Co. and Dainichiseika Color & Chemicals Manufacturing Co. | Date: 2017-01-25

Provided is an ophthalmic lens, from which the elution of a coloring agent can be prevented effectively even when the ophthalmic lens is produced by polymerizing a polymerizable composition containing the coloring agent or when the ophthalmic lens is produced by printing an ink composition containing a coloring agent on a lens precursor by a know printing technique such as an inkjet printing method to allow the coloring agent to penetrate into the lens precursor. The ophthalmic lens is produced using a non-polymerizable compound represented by a specific structural formula as a coloring agent.


Patent
Menicon Co. and Shin - Etsu Chemical Co. | Date: 2016-06-02

A polysiloxane-based macromonomer for an ophthalmic lens, which exhibits excellent compatibility with respect to a hydrophilic component such as a hydrophilic monomer. The polysiloxane-based macromonomer has at least one polymerizable group, a polysiloxane chain having a siloxane unit as a repeating unit, a polyoxyethylene chain in which a number of repetition of an oxyethylene group is two or more, and a polyoxyalkylene chain having an oxyalkylene group other than the oxyethylene group as a repeating unit, wherein an HLB value calculated according to a formula: [HLB value]=E/5 is within a range from 0.7 to 6.0, wherein E represents a weight fraction (wt %) of the oxyethylene group in a molecule of the polyxiloxane-based macromonomer.


Patent
Menicon Co. and Shin - Etsu Chemical Co. | Date: 2016-10-26

A polysiloxane-based macromonomer for an ophthalmic lens, which exhibits excellent compatibility with respect to a hydrophilic component such as a hydrophilic monomer. The polysiloxane-based macromonomer has at least one polymerizable group, a polysiloxane chain having a siloxane unit as a repeating unit, a polyoxyethylene chain in which a number of repetition of an oxyethylene group is two or more, and a polyoxyalkylene chain having an oxyalkylene group other than the oxyethylene group as a repeating unit, wherein an HLB value calculated according to a formula: [HLB value] = E/5 is within a range from 0.7 to 6.0, wherein E represents a weight fraction (wt%) of the oxyethylene group in a molecule of the polyxiloxane-based macromonomer.


A designing method of a contact lens for myopia progression suppression including: providing a tonic accommodation relaxation region in which an additional power whose maximum value is from +0.25 to +0.75 diopters is set with respect to a correction power that is required for realizing a proper correction, the additional power being capable of relaxing a tonic accommodation without improving an aberration off an optical axis and an accommodation lag on the optical axis; and providing a proper correction region in which the additional power is not set at least on an optical center.


Patent
Menicon Co. | Date: 2016-08-29

A disinfection system of a contact lens comprising immersing the contact lens in a disinfecting solution containing hydrogen peroxide in a concentration of 1 to 10% and neutralizing the hydrogen peroxide in the disinfecting solution through contact with a metal catalyst, where the disinfecting solution contains an organic carboxylic acid or a salt of the organic carboxylic acid, the organic carbbxylic acid having a structure in which a hydroxyl group and a carboxyl group are bonded to one carbon atom; the disinfecting solution is adjusted to have a pH of 6 to 8; and the disinfecting solution after the neutralization is adjusted to have an osmotic pressure of 250 to 350 mOsm.


Patent
Menicon Co. | Date: 2016-06-09

An ophthalmic lens which gives excellent wearing comfort required for its use as a contact lens, and which has sufficiently high flexibility and an adequate degree of deformation recovery property required for its use as an intraocular lens. The ophthalmic lens is formed of a polymer having a youngs modulus of 0.3-1.0 MPa and a stress relaxation rate of 10-20%.


Patent
Menicon Co. | Date: 2016-10-26

An ophthalmic lens which gives excellent wearing comfort required for its use as a contact lens, and which has sufficiently high flexibility and an adequate degree of deformation recovery property required for its use as an intraocular lens. The ophthalmic lens is formed of a polymer having a youngs modulus of 0.3-1.OMPa and a stress relaxation rate of 10-20%.


Patent
Menicon Co. | Date: 2016-06-15

A presbyopia contact lens set especially for a user who has worn spherical contact lenses, a designing method for a presbyopia contact lens, and a manufacturing method for a presbyopia contact lens that uses such design method. The presbyopia contact lens set configured by combining a plurality of types of presbyopia contact lens having different specifications lens powers, includes the plurality of types of presbyopia contact lenses in which the radial lens power profile in a near-use region and that in a far-use region are defined using mutually different functions, the function for defining the radial lens power profile in the far-use region is set in accordance with a specifications lens power, and the radial lens power rate-of-change in the far-use region is made larger for lenses having a small specifications lens power than for lenses having a large specifications lens power.

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