Mengucek Gazi Training and Research Hospital Erzincan

Gazi, Turkey

Mengucek Gazi Training and Research Hospital Erzincan

Gazi, Turkey

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PubMed | Mengucek Gazi Training and Research Hospital Erzincan and Erzincan University
Type: Journal Article | Journal: International journal of clinical and experimental medicine | Year: 2015

In recent years, there has been renewed interest in hematological parameters as predictors of endothelial dysfunction and inflammation. The aim of our study is to evaluate the relationship between HbA1c and hematological indices, and to evaluate the relationship between these parameters and microvascular complications of diabetes. Three hundred and seven diabetic patients (124 male, 183 female; mean age 50.88.5), and 187 controls (76 male, 111 female; mean age 51.110.1) were included in the study. In the diabetic group, mean platelet volume (MPV), plateletcrit (PCT), platelet distribution width (PDW), white blood cell count (WBC), platelet count, platelet to lymphocyte ratio (PLR) and neutrophil to lymphocyte ratio (NLR) were significantly higher than the control group (P<0.05). Diabetic patients were divided into two group according to their HbA1c levels (Group 1; HbA1c <7 (n=82) and group 2; HbA1c 7 (n=225)). Mean platelet volume, PCT and PDW levels were significantly increased in group 2. Mean platelet volume was significantly increased in diabetic patients with retinopathy compared to those without retinopathy (P=0.006). The neutrophil to lymphocyte ratio and PLR levels were significantly higher in patients with nephropathy (P=0.004, P=0.004 respectively). There was statistically significant difference of lymphocyte count between patients with and without neuropathy. In correlation analysis, positive correlation between HbA1c and PCT (rs=0.192, P<0.001), HbA1c and PDW (rs=0.305, P<0.001), HbA1c and MPV (rs=0.352, P<0.001) were determined. In binary logistic regression analysis; WBC, PDW and PLR levels were found to be independently associated with diagnosis of diabetes while WBC, MPV, PLR and NLR levels were found to be independently associated with impaired glucose regulation. This study demonstrates that altered hematological indices are closely associated with HbA1c levels in individuals with and without diabetes and some of these parameters are associated with diabetic microvascular complications. These associations may be explained by connection between these easy accessible and inexpensive hematological indices and inflammation, tendency to coagulation and thrombosis in patients with diabetes.


PubMed | Mengucek Gazi Training and Research Hospital Erzincan and Firat University
Type: Journal Article | Journal: International journal of clinical and experimental medicine | Year: 2015

Doxorubicin (DXR) is an antineoplastic agent of the anthracycline group, and may show nephrotoxic effects in animal models and humans. We investigated changes in kidney tissue following doxorubicin treatment and the effects of vitamin D on kidney tissue and TRPV1 channels. In this study, 24 adult male Wistar Albino rats were used. The animals were divided into four groups of six animals. During the 14-day experiment period, Group I did not have any application. 200 IU/day cholecalciferol was administered orally to Group II. Group III received 10 mg/kg single dose of DXR intraperitoneally (IP); and Group IV had a single 10 mg/kg dose of IP DXR and 200 IU/day of oral cholecalciferol. At the end of the experiment, the rats were decapitated, and their kidney tissues were removed. TRPV1 expression and apoptosis were detected in the tissue section by using immunohistochemical, TUNEL and real time-PCR (RT-PCR) techniques. The findings were examined and photographed with BH2 Olympus photomicroscope. As result of immunohistochemical staining, RT-PCR and examination with light microscope, it was found that the TRPV 1 immunoreactivity of the DXR group decreased in comparison with the control group, and the vitamin D application did not reverse this effect. Apoptosis detected by the TUNEL method tended to increase in the doxorubicin group and was relatively reversed with the administration of vitamin D. Tissue malondialdehyde (MDA) levels were observed to correlate with the findings of apoptosis. This study showed that vitamin D has anti- apoptotic and antioxidant effects on kidney tissue after DXR-induced injury.


PubMed | Emek Hospital Gaziantep, Mengucek Gazi Training and Research Hospital Erzincan and Firat University
Type: Journal Article | Journal: International journal of clinical and experimental medicine | Year: 2015

Adipocytes are not only for energy storage, but are also functionally active cells, producing biologically active peptides called adipocytokines. Adipocytokines control nutrition, thermogenesis, immunity, thyroid and reproductive hormones, and neuroendocrine functions. One of the most important new members of this family is apelin. In patients with thyroid dysfunctions, there are usually changes in weight, thermogenesis and adipose tissue lipolysis. Here, we investigated the serum apelin levels in different thyroid hormone states. Our study group consisted of the following patients: 32 thyrotoxicosis, 32 subclinical hyperthyroidism, 31 hypothyroidism, 34 subclinical hypothyroidism and 31 healthy control cases. In addition to routine blood tests, serum free T3 (FT3), free T4 (FT4), TSH and apelin levels were measured, and the body mass index (BMI) was recorded. In terms of the demographic characteristics, age and BMI, there was no statistically significant difference between the groups (P>0.05). The mean serum apelin levels of the groups were as follows: thyrotoxicosis group, 4.61.9 ng/ml; subclinical hyperthyroidism group, 3.71.9 ng/ml; hypothyroid group, 4.82.5 ng/ml; subclinical hypothyroidism group, 4.32.2 ng/mL; and control group, 3.41.4 ng/ml, respectively. There was no statistically significant difference in terms of the mean apelin levels between the groups (P>0.05). The hypothyroid group had the highest and the control group had the lowest mean apelin levels. As a result, the apelin levels were higher in both the patients with hypothyroidism and hyperthyroidism, in comparison with the normal population, but without statistical significance.


PubMed | Mengucek Gazi Training and Research Hospital Erzincan
Type: Journal Article | Journal: Clinical case reports | Year: 2015

Organ dysfunctions caused by intraabdominal hypertension is named as abdominal compartment syndrome (ACS). A patient with prostate cancer admitted with dyspnea and oliguria. After decompression his health status improved. For patients with malignant disorders presented with oliguria and respiratory problems who have abdominal distension, ACS should be in mind.

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