Meluna Research

Geldermalsen, Netherlands

Meluna Research

Geldermalsen, Netherlands

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PubMed | Leiden University, University of Chinese Academy of Sciences, BGI Shenzhen, Meluna Research and James D Watson Institute Of Genome Science
Type: | Journal: Journal of photochemistry and photobiology. B, Biology | Year: 2016

Aging has been one of the several topics intensely investigated during recent decades. More scientists have been scrutinizing mechanisms behind the human aging process. Ultra-weak photon emission is known as one type of spontaneous photon emission that can be detected with a highly sensitive single photon counting photomultiplier tube (PMT) from the surface of human bodies. It may reflect the bodys oxidative damage. Our aim was to examine whether ultra-weak photon emission from a human hand is able to predict ones chronological age. Sixty subjects were recruited and grouped by age. We examined four areas of each hand: palm side of fingers, palm side of hand, dorsum side of fingers, and dorsum side of hand. Left and right hand were measured synchronously with two independent PMTs. Mean strength and Fano factor values of photon counts were utilized to compare the UPE patterns of males and females of different age groups. Subsequently, we utilized UPE data from the most sensitive PMT to develop an age prediction model. We randomly picked 49 subjects to construct the model, whereas the remaining 11 subjects were utilized for validation. The results demonstrated that the model was a good regression compared to the observed values (Pearsons r=0.6, adjusted R square=0.4, p=9.4E-7, accuracy=49/60). Further analysis revealed that the average difference between the chronological age and predicted age was only 7.60.8years. It was concluded that this fast and non-invasive photon technology is sufficiently promising to be developed for the estimation of biological aging.


Van Wijk R.,Meluna Research | Van der Greef J.,Leiden University | Van der Greef J.,Applied Scientific Research | Van Wijk E.,Meluna Research | Van Wijk E.,Leiden University
JAMS Journal of Acupuncture and Meridian Studies | Year: 2010

The relationship between connective tissue and meridian function is discussed in terms of energy transmission. The network of hydrogen-bonded water molecules interspersed within the collagen fibrillar matrix is especially significant for both the sensitivity of connective tissue to weak signals of mechanical pressure, heat, or electricity and the electrical intercommunication that may correlate with the meridian acupuncture system. Special electromagnetic properties of connective tissue have similar collective properties of ultraweak photon emission. A relationship between ultraweak photon emission and yin yang dynamics is based on three types of ultraweak photon emission studies, focusing on diurnal and annual dynamics, diseased states, and acupuncture points. A novel concept explains the functional (health) integrity of physiologic systems in relation to the left-right balance in ultraweak photon emission by pointing to, (1) balanced corticoneuromusculoskeletal activities and triboluminescent aspects of ultraweak photon emission by skeletal structures, and (2) local fine-tuning in oxygen supply and the formation of radical oxygen species. This approach offers testable hypotheses for further validation utilizing a combination of human photon recording techniques and specialized metabolomics for the estimation of organ-specific oxidative states. © 2010 Korean Pharmacopuncture Institute.


Bajpai R.P.,Leiden University | Van Wijk E.P.A.,Leiden University | Van Wijk E.P.A.,Meluna Research | Van Wijk R.,Leiden University | And 3 more authors.
Journal of Photochemistry and Photobiology B: Biology | Year: 2013

Sixty visible range photon signals spontaneously emitted from the dorsal side of both hands of fifteen human subjects are analyzed with the aim of finding their attributes. The signals are of 30 min duration and detected in bins of 50 ms by two synchronized photo multipliers sensitive in the range (290-630 nm). Each signal is a time series of 36,000 elements. The attributes of its signal are determined from the statistical properties of time series. The mean and variance of time series determine the attributes signal strength and intercept (p0) and slope (p1) of the Fano Factor curve. The photon count distribution of the time series determines squeezed state parameters |α|, r, θ and, squeezed state index (SSI), and sum of the squares of residue (SSR). The correlation between simultaneously detected signals determines intercept (c0) and slope (c1) of their correlation curve. The variability of attributes is studied by calculating them in smaller intervals covering the entire signal. The profile of attribute at 12 sites in a subject is more informative and biologically relevant. © 2013 Elsevier B.V. All rights reserved.


Van Wijk E.,Leiden University | Van Wijk E.,Meluna Research | Van Wijk E.,Samueli Institute | Kobayashi M.,Tohoku Institute of Technology | And 4 more authors.
PLoS ONE | Year: 2013

Ultra-weak photon emission (UPE) of a living system received scientific attention because of its potential for monitoring increased levels of reactive oxygen species (ROS) in the pathogenesis of rheumatoid arthritis (RA). In this study, a highly sensitive cryogenic charge-coupled device (CCD) camera was used to monitor in a RA mouse model the photon emission both without and with luminol. For that purpose, arthritis was induced in mice utilizing a repeated co-administration of type II collagen with lipopolysaccharide. Quantitative imaging of ultra-weak photon emission of the front and back paws of the animals was initiated 70 days after the first injection. All of the animals were measured once without luminol and once again immediately after luminol injection. Data illustrated a higher UPE intensity after initiating arthritis by CII-injection of the animals. The increase in UPE intensity was measured with and without using luminol indicating that this imaging technology may be useful for the future study of human RA. © 2013 van Wijk et al.


Clausen J.,Veronica | van Wijk R.,MeLuNa Research | Albrecht H.,Veronica
Homeopathy | Year: 2014

The database HomBRex (Homeopathy Basic Research experiments) was established in 2002 to provide an overview of the basic research already done on homeopathy (http://www.carstens-stiftung.de/hombrex). By this means, it facilitates the exploration of the Similia Principle and the working mechanism of homeopathy. Since 2002, the total number of experiments listed has almost doubled. The current review reports the history of basic research in homeopathy as evidenced by publication dates and origin of publications.In July 2013, the database held 1868 entries. Most publications were reported from France (n=267), followed by Germany (n=246) and India (n=237). In the last ten years, the number of publications from Brazil dramatically increased from n=13 (before 2004) to n=164 (compared to n=251 published in France before 2004, and n=16 between 2004 and 2013). The oldest database entry was from Germany (1832). © 2014 The Faculty of Homeopathy.


PubMed | Veronica and MeLuNa Research
Type: Journal Article | Journal: Homeopathy : the journal of the Faculty of Homeopathy | Year: 2014

The database HomBRex (Homeopathy Basic Research experiments) was established in 2002 to provide an overview of the basic research already done on homeopathy (http://www.carstens-stiftung.de/hombrex). By this means, it facilitates the exploration of the Similia Principle and the working mechanism of homeopathy. Since 2002, the total number of experiments listed has almost doubled. The current review reports the history of basic research in homeopathy as evidenced by publication dates and origin of publications. In July 2013, the database held 1868 entries. Most publications were reported from France (n = 267), followed by Germany (n = 246) and India (n = 237). In the last ten years, the number of publications from Brazil dramatically increased from n = 13 (before 2004) to n = 164 (compared to n = 251 published in France before 2004, and n = 16 between 2004 and 2013). The oldest database entry was from Germany (1832).


Van Wijk R.,Meluna Research | Wiegant F.A.C.,University Utrecht
Homeopathy | Year: 2015

Background: Phials containing high dilutions of homeopathic remedies are commonly utilized in diagnostic tools in combination with electro acupuncture measuring electrical conductivity of the skin. The present research aimed to elucidate the interaction of the homeopathic remedy and the human organism. Method: The study protocol included the transition of a healthy subject to a diseased state utilizing a sub-harmful dose of a toxin. Subsequently, the subject was exposed to a homeopathic or placebo remedy in a closed glass phial and electrical conductivity was measured in open as well as in blind trials. A total of 229 data were collected from open trials and 750 data from blind trials. Result: The experimental data showed that homoeopathic remedies in closed glass phials may influence the electrical skin conductivity. The results of the blind trials differed considerably from those of the open trials. The percentage of correctly identified (verum and placebo) phials in the open trials (85%) was statistically different from those in the blind trials (65%). In both types of trials, however, the difference between the sealed phials containing the homeopathic medicine and the placebo was statistically significant. The results of measurements are directly linked to the way in which the tester holds the electrode in one hand and the subject's finger in the other, while putting pressure on the electrode. Conclusion: It was concluded that the tester's muscle tone is the intermediary in unconsciously selecting which phial influenced him in his specific contact with the subject. © 2015 The Faculty of Homeopathy.


Scholkmann F.,University of Zürich | Schraa O.,Meluna Research | Van Wijk R.,Meluna Research | Wolf M.,University of Zürich
Advances in Experimental Medicine and Biology | Year: 2013

Ultra-weak photon emission (UPE) is a general feature of living-biological systems. To gain further insights into the origin of UPE and its physiological significance, the aim of the present study was to investigate the connection between hemodynamics (HD), oxygenation (OX), and UPE. Therefore, during venous and arterial occlusion (VO, AO), changes of UPE and surrogates of HD as well as OX were measured simultaneously using two photomultipliers and near-infrared spectroscopy, respectively. We showed that (1) changes in UPE correlate significantly nonlinearly with changes in oxyhemoglobin (Δ[O 2Hb]), deoxyhemoglobin (Δ[HHb]), and hemoglobin difference (Δ[HbD] = Δ[O2Hb]-Δ[HHb]), indicating a complex association between UPE and tissue HD/OX; (2) UPE decreases significantly during AO but not during VO; (3) UPE increases significantly after AO; and (4) the view that ROS are the source of UPE is generally supported by the present study, although some findings remain unexplained in the context of the theory of ROS-mediated UPE generation. In conclusion, the present study revealed new insights into the interplay between HD, OX, and UPE and opens up new questions that have to be addressed by future studies. © 2013 Springer Science+Business Media New York.


Gallep C.M.,University of Campinas | Barlow P.W.,University of Bristol | Burgos R.C.R.,Leiden University | van Wijk E.P.A.,Leiden University | van Wijk E.P.A.,Meluna Research
Protoplasma | Year: 2016

In order to corroborate the hypothesis that variations in the rate of spontaneous ultra-weak photon emission (UPE) from germinating seedlings are related to local variations of the lunisolar tidal force, a series of simultaneous tests was performed using the time courses of UPE collected from three plant species—corn, wheat and sunflower—and also from wheat samples whose grains were transported between continents, from Brazil to The Netherlands and vice versa. All tests which were run in parallel showed coincident inflections within the UPE time courses not only between seedlings of the same species but also between the different species. In most cases, the UPE inflections were synchronised with the turning points in the local gravimetric tidal variation. Statistical tests using the local Pearson correlation verified these coincidences in the two time series. The results therefore support the hypothesis of a relationship between UPE emissions and, in the oscillations, the local gravimetric tide. This applies to both the emissions from seedlings of different species and to the seedlings raised from transported grain samples of the same species. © 2016 Springer-Verlag Wien


Van Wijk R.,International Institute of Biophysics | Van Wijk R.,Meluna Research | Wiegant F.A.C.,University Utrecht
Frontiers in Bioscience - Elite | Year: 2011

Postexposure conditioning, as a part of hormesis, involves the application of a low dose of stress following exposure to a severe stress condition. The beneficial effect of a low level of stress in postconditioning hormesis is illustrated by a number of examples found in experimental and clinical research. Depending on whether the low-dose stress is of the same type of stress or is different from the initial high-dose stress causing the diseased state, postconditioning is classified as homologous or heterologous, respectively. In clinical homeopathy, where substances are applied according to the Similia principle, the same distinction is found between the isopathic and the 'heteropathic' or homeopathic use of low dose substances. The Similia principle implies that substances causing symptoms in healthy biological systems can be used to treat similar symptoms in diseased biological systems. Only when heterologous substances are tested for therapeutic effects, the Similia principle can be studied. It is then possible to compare the effect of treatment with the degree of similarity between the diseased state and the effects caused by different substances. The latter research was mainly performed with cells in culture using heat shocked cells post exposed to a variety of stress conditions in low dose.

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