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Madhusudhan Rao V.,Melmaruvathur Adhiparasakthi Institute of Medical Science | Vijayakumar A.K.,Birla Institute of Technology and Science
Biomedicine (India)

Propositions about the brain lead to far reaching conclusions about the Mind-Body problem, epistemology and the source of knowledge, neural correlates of metaphysics, the necessity of a biological imperative that overrules constraints that do not allow induction and deduction as logical fallacies, the nature of the universe, consequences of Bayes theorem for the all important question on the existence of God. From what is known about the brain the propositions are self evident that in the brain there are unique molecules that encode sensation, property of object as perceived, ideas, thoughts and belief which arise as consciousness, awareness or mind when the molecules are activated by electrical activity of the brain. This follows from Penfield's finding that electrical stimulation of the brain gives rise to sensations and thoughts and Hyden's finding that injected RNAbrings about particular behaviour. This is formally stated and the conclusions to say the least are startling. Source

Nath C.K.,NEIGRIHMS | Baruah M.,Melmaruvathur Adhiparasakthi Institute of Medical Science | Nath I.,North Bengal Medical College | Bayan A.C.,Binapani Nursing Home and Hospital
Biosciences Biotechnology Research Asia

Preeclampsia is a pregnancy specific syndrome of reduced organ perfusion secondary to vasospasm and endothelial activation. A number of reports indicate that preeclampsia is associated with elevated blood levels of lipid peroxidation products. The present study was undertaken to evaluate the metabolic correlation between preeclampsia and oxidative stress. 95 no of subjects was selected out for the study out of which normal nonpregnant control group had 25 subjects, normal pregnant control group had 40 subjects & preeclampsia group constituted of 30 subjects. The investigations included are serum lipid profile consisting of serum total cholesterol, serum triglycerides, VLDL, LDL and HDL, serum vitamin E as á- tocopherol and malondialdehyde. There is significant increase in serum triglyceride, serum cholesterol along with LDL and VLDL (p<0.0001) in pregnancy over nonpregnant controls and preeclampsia over pregnant control (p Source

Nallam S.R.,Melmaruvathur Adhiparasakthi Institute of Medical Science | Dara S.,Melmaruvathur Adhiparasakthi Institute of Medical Science
Indian Journal of Anaesthesia

Background and Aims: Sudden, profound hypotension and bradycardia events (HBEs) have been reported in more than 20% of patients undergoing shoulder arthroscopy in the sitting position. The present study was designed to know whether intravenous (IV) ondansetron (selective 5-hydroxy tryptamine 3-antagonist) can help in reducing the HBEs associated with shoulder arthroscopy performed in sitting position under interscalene brachial plexus block (ISBPB). Methods: A total of 100 patients (age 20–50 years) undergoing shoulder arthroscopy performed in the sitting position under ISBPB were assigned randomly to one of the two groups: Group C received 10 ml of normal saline and Group T received 4 mg of ondansetron diluted in 10 ml of normal saline` IV. All patients received ISBPB using levobupivacaine 0.5%. Assessment of motor and sensory blockade, pulse rate, systolic blood pressure, respiration, and side effects were noted every 5 min for first 30 min and every 10 min till the end of surgery. HBEs were recorded in both groups. Results: IV injection of ondansetron significantly reduces the incidence of HBEs from 11 (22.44% in Group C) to 3 (6.1% in Group T). The duration of analgesia was significantly longer in Group C (8.1 ± 3.3) in comparison with Group T (6.3 ± 4.2 h). Conclusion: We conclude that 4 ml of IV ondansetron can significantly reduce the HBEs during shoulder arthroscopy done in the sitting position under ISBPB. © 2015, Indian Journal of Anaesthesia. All rights reserved. Source

Pragash D.S.,Melmaruvathur Adhiparasakthi Institute of Medical Science | Mangaiyarkarasi,Sri ManakulaVinayagar Medical College | Ragunathan L.,Aarupadai Veedu Medical College | Rayapu V.,Melmaruvathur Adhiparasakthi Institute of Medical Science | Shaker I.A.,Melmaruvathur Adhiparasakthi Institute of Medical Science
International Journal of Pharma and Bio Sciences

An extended spectrum beta lactamase (ESBL) production among gram-negative bacilli has emerged as a significant mechanism of resistance to oxyimino-cephalosporin antibiotics during the last 3 decades. Detection of common ESBL genes such as CTX-M and SHV by molecular methods in ESBL-producing bacteria and their pattern of antimicrobial resistance can provide useful information about its epidemiology and aid in rational antimicrobial therapy. A total of 138 multi drug resistant clinical isolates of Enterobacteriaceae family obtained from pyogenic lesions were included in the study. Antibiotic susceptibility test, Phenotypic confirmatory methods, Minimum inhibitory concentration and detection of CTX-M and SHV genes by Polymerase chain reaction were performed. Out of 138 samples, 84 were ESBL producers. Among the 84 isolates CTX-M gene was seen in 55 (65.5%) isolates, SHV was seen in 16 (19%) isolates and both CTX-M and SHV was seen in 14 (16.7%). A strict monitoring mechanism of antimicrobial resistance is necessary because of the high rate of prevalence of CTX-M and SHV genes among gram negative organisms causing clinically significant infections. Source

Raja G.,Melmaruvathur Adhiparasakthi Institute of Medical Science | Shaker I.A.,Melmaruvathur Adhiparasakthi Institute of Medical Science
International Journal of Pharma and Bio Sciences

The present study was undertaken to evaluate the effect of oxidative stress in chronic renal failure patients before and after hemodialysis and compared to healthy control individuals. The study comprised of 30 hemodialysis patients compared with 30 healthy controls. The object of the present study was to investigate the possible free radical mediated tissue damage in CRF before and after dialysis, by measuring Malondialdehyde (MDA) which is marker of oxidative stress and L-carnitine for lipid peroxidation. MDA levels were found to be significantly increased in pre dialysis CRF patients as compared to the controls (P< 0.001) and the levels further increased in post dialysis CRF patients as compared to that in pre dialysis CRF patients (P <0.001). Antioxidant enzymes such as superoxide dismutase, catalase, reduced glutathione, glutathione peroxidase and the levels of antioxidants like Vitamin A, Vitamin E and Vitamin C along with L-carnitine were significantly decreased in pre dialysis patients as compared to the controls (P<0.001) and the values further significantly decreased in post dialysis patients as compared to the pre dialysis CRF patients (P<0.001). The result of study have shown there is considerable oxidative stress in patients with CRF, which is further exacerbated by hemodialysis, as evidenced by increased lipid peroxidation and low levels of antioxidant and L-carnitine. Source

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