Nohara A.,Meijo Hospital
Spine | Year: 2017
STUDY DESIGN.: Retrospective comparative Study OBJECTIVE.: To evaluate the difference in trends of disc degeneration (DD) at Lower unfused segments (LUS) for post-operative patients who have gone through spinal instrumentation at 10-year follow-up with the natural progression of idiopathic scoliosis. SUMMARY OF BACKGROUND DATA.: Studies that used MRI state that DD rates at LUS are higher than in the normal population. However, current studies do not prove that surgery is the most effective clinical method to treat idiopathic scoliosis, as no existing report compares the rates of DD with the natural history of idiopathic scoliosis. METHODS.: Female patients diagnosed of scoliosis were divided into 3 groups: a) surgical group: postoperative 10-year patients with severe scoliosis prior to operation, b) mild scoliosis group: with comparatively equal scoliosis to postoperative patients of the same age at 10 years follow-up c) severe scoliosis group: without any record of corrective surgery under the assumption that the scoliosis of the surgical group have progressed according to natural history. RESULTS.: MRI findings of the surgical group show DD in 32 patients (62.7%) where the highest rate of DD occurred at L5/S. In the mild scoliosis group, 21 patients (47.7%) had DD; with higher rates at L4/5 and L5/S. DD was most common in L3/4 and L4/5 in the severe scoliosis group where 27 patients (81.8%) had DD. As such, DD rates were significantly higher in the severe scoliosis group than the surgical group at the same spinal level. The same was true for the existence of low back pain, where the severe scoliosis group had greater incidence of low back pain than the surgical group. CONCLUSION.: Corrective surgeries were able to reduce the incidence of DD. Radiological analysis also suggests that surgical intervention is a clinically feasible treatment for idiopathic scoliosis patients.Level of Evidence: 3 Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.
Takahashi Y.,RIKEN |
Takahashi Y.,Keio University |
Kou I.,RIKEN |
Takahashi A.,RIKEN |
And 21 more authors.
Nature Genetics | Year: 2011
Adolescent idiopathic scoliosis is a pediatric spinal deformity affecting 2-3% of school-age children worldwide. Genetic factors have been implicated in its etiology. Through a genome-wide association study (GWAS) and replication study involving a total of 1,376 Japanese females with adolescent idiopathic scoliosis and 11,297 female controls, we identified a locus at chromosome 10q24.31 associated with adolescent idiopathic scoliosis susceptibility. The most significant SNP (rs11190870; combined P = 1.24 × 10 -19; odds ratio (OR) = 1.56) is located near LBX1 (encoding ladybird homeobox 1). The identification of this susceptibility locus provides new insights into the pathogenesis of adolescent idiopathic scoliosis. © 2011 Nature America, Inc. All rights reserved.
PubMed | Keio University, RIKEN, Japan National Institute of Health Sciences, Hokkaido University and 3 more.
Type: | Journal: Human mutation | Year: 2017
Congenital scoliosis (CS) occurs as a result of vertebral malformations and has an incidence of 0.5-1/1,000 births. Recently, TBX6 on chromosome 16p11.2 was reported as a disease gene for CS; about 10% of Chinese CS patients were compound heterozygotes for rare null mutations and a common haplotype defined by three SNPs in TBX6. All patients had hemivertebrae. We recruited 94 Japanese CS patients, investigated the TBX6 locus for both mutations and the risk haplotype, examined transcriptional activities of mutant TBX6 in vitro, and evaluated clinical and radiographic features. We identified TBX6 null mutations in nine patients, including a missense mutation that had a loss of function in vitro. All had the risk haplotype in the opposite allele. One of the mutations showed dominant negative effect. Although all Chinese patients had one or more hemivertebrae, two Japanese patients did not have hemivertebra. The compound heterozygosity of null mutations and the common risk haplotype in TBX6 also causes CS in Japanese patients with similar incidence. Hemivertebra was not a specific type of spinal malformation in TBX6-associated CS (TACS). A heterozygous TBX6 loss-of-function mutation has been reported in a family with autosomal-dominant spondylocostal dysostosis, but it may represent a spectrum of the same disease with TACS.
Lee S.-H.,Kyung Hee University |
Lee J.C.,Soonchunhyang University |
Tauchi R.,Meijo Hospital |
Daniel Riew K.,Columbia University
Spine | Year: 2016
Study Design. A retrospective study. Objective. To analyze the influence of the number of cervical fusion levels on total cervical motion and health-related quality of life (HRQoL) in patients with solid anterior cervical fusions (ACFs). Summary of Background Data. Few studies have analyzed the degree to which cervical range of motion (ROM) and HRQoL are affected by the number of cervical fusion segments. Methods. We analyzed a cohort of patients who underwent ACF for degenerative disc disease. To assess the clinical outcomes and HRQoL, preoperative, 1-and 2-year postoperative neck and arm pain, visual-analogue scale, neck disability index, and short form-36 were analyzed. Radiographically, C2-7 and C0-2 ROM, C2-7 sagittal vertical axis (SVA), and Kellgren grade of radiographic adjacent segment pathology (RASP) were evaluated. Results. A total of 105 patients (M:F=46:59, mean age of 51.4 yr) were enrolled. There were 36 patients who underwent single-level ACF (group 1), 41 patients who had a double level ACF (group 2), and 28 patients who underwent ACF involving 3 or more levels (group 3). There was no decrease in C2-7 motion in group 1, a mean 7-degree decrease in group 2, a mean 18-degree decrease in those who underwent a 3-level ACF, and a mean 22-degree decrease after 4-level ACF. The grade of RASP was not influenced by the number of fusion levels. All HRQoL parameters showed no significant correlation between number of fusion levels, cervical ROM, and SVA. Conclusion. Single-level ACF showed no decrease in total cervical motion; multilevel ACF decreased cervical motion by a mean of 7.8 degrees per segment of fusion. Progression of RASP showed no correlation with the number of fusion levels. HRQoLs were not influenced by the number of fusion levels, cervical ROM, or SVA after solid ACF. Level of Evidence: 3 © 2016 Wolters Kluwer Health, Inc.
Morse L.J.,University of California at San Francisco |
Kawakami N.,Meijo Hospital |
Lenke L.G.,Washington University |
Sucato D.J.,Texas Scottish Rite Hospital for Children |
And 2 more authors.
Spine | Year: 2012
Study Design. Retrospective comparative study. Objective. To report preoperative differences in the Scoliosis Research Society Outcomes Instrument (SRS-30) between multiple US ethnicities and native Japanese and Korean children with adolescent idiopathic scoliosis (AIS). Summary of Background Data. The SRS-24 was developed in a US cohort with AIS. Comparative studies using the SRS-24 between US and Japanese patients showed differences, suggesting that culture might affect functional outcome. Methods. Preoperative SRS-30 outcomes were collected from 1853 children with AIS from 6 different ethnic groups: US white (1234), black (213), Hispanic (78), and Asian (29), as well as native Japanese (192) and Koreans (107). Analysis of covariance of 4 SRS-30 domains (pain, appearance, activity, and mental) was compared between groups adjusting for differences in age, sex, major curve magnitude, and body mass index. Pairwise comparisons of the 4 SRS-30 domains were adjusted for multiple comparisons, using Bonferroni correction. A P value of less than 0.05 was considered significant. Results. Significant differences between ethnicities were found in all domains (P < 0.001). Whites reported more pain than Japanese or Koreans (Japanese = 4.52, Korean = 4.47, white = 4.04). Korean and Japanese patients had the lowest appearance scores (Japanese = 2.89, Korean = 2.73, US Asian = 3.55, Hispanic = 3.11, black = 3.47, white = 3.29). Koreans also had the lowest activity (Korean = 3.64, Japanese = 4.24, US Asian = 4.07, Hispanic = 4.02, black = 4.06, white = 4.16), mental (Korean = 3.70, Japanese = 4.23, US Asian = 4.05, Hispanic = 3.75, black = 4.03, white = 3.94), and total scores (Korean = 3.63, Japanese = 3.92, US Asian = 4.02, Hispanic = 3.75, black = 3.92, and white = 3.84). Conclusion. Culture and ethnicity influence SRS-30 outcomes in AIS. Whites reported more pain than Japanese and Koreans. Japanese and Koreans had the lowest appearance scores. Koreans additionally were distinguished by the lowest activity, mental, and total scores. These cultural and ethnic differences must be taken into account when counseling patients with AIS and studying functional outcomes. © 2012 Lippincott Williams & Wilkins.
Ichikawa S.,Meijo Hospital
Kyobu geka. The Japanese journal of thoracic surgery | Year: 2011
A 69-year-old male with a history of total esophagectomy and substernal placement of the gastric tube for esophageal carcinoma was admitted due to an unstable angina. Cardiac catheterization revealed a severe stenosis just proximal to the left anterior descending coronary artery and a 75% stenosis of the right coronary artery. Intraaortic balloon pumping was started in the catheter laboratory. Off-pump coronary artery bypass grafting was performed through left thoracotomy. The left internal mammary artery could not be utilized as a bypass graft to the left anterior descending artery due to severe substernal adhesion. Percutaneous coronary intervention was selected for the revascularization of the right coronary artery lesion.
Jin C.X.,Jilin University |
Hayakawa T.,Meijo Hospital |
Ko S.B.H.,Nagoya University |
Ishiguro H.,Nagoya University |
Kitagawa M.,Nagoya University of Arts and Sciences
Internal Medicine | Year: 2011
Pancreatic stone protein (PSP; reported in 1979), pancreatitis-associated protein (PAP; 1984) and regenerating protein (Reg I; 1988) were discovered independently in the fields of the exocrine (pancreatitis) and endocrine (diabetes) pancreas. Subsequent analysis revealed that PSP and Reg I are identical and PAP belongs to the same protein family. PSP/Reg I and PAP share a selective and specific trypsin cleavage site and result in insoluble fibrils (PTP, PATP). Search for a functional role of PSP had led to the idea that it might serve as an inhibitor in pancreatic stone formation and PSP was renamed lithostathine. Inhibitory effects of lithostathine in stone formation have been questioned. Evidence so far obtained can support a lithogenic role rather than a lithostatic role of PSP. PAP and its isoforms have been investigated mainly regarding responses to inflammation and stress. Reg I and its isoforms have been examined on regeneration, growth and mitogenesis in gastrointestinal neoplastic diseases as well as diabetes. Evidence obtained can be applied in the prediction of prognosis and therapy for inflammatory and neoplastic diseases. © 2011 The Japanese Society of Internal Medicine.
Imagama S.,Showa University |
Matsuyama Y.,Showa University |
Yukawa Y.,Nagoya University |
Yukawa Y.,Chubu Rosai Hospital |
And 7 more authors.
Journal of Bone and Joint Surgery - Series B | Year: 2010
We have reviewed 1858 patients who had undergone a cervical laminoplasty and identified 43 (2.3%) who had developed a C5 palsy with a MMT (MRC) grade of 0 to 2 in the deltoid, with or without involvement of the biceps, but with no loss of muscular strength in any other muscles. The clinical features and radiological findings of patients with (group P; 43 patients) and without (group C; 100 patients) C5 palsy were compared. CT scanning of group P revealed a significant narrowing of the intervertebral foramen of C5 (p < 0.005) and a larger superior articular process (p < 0.05). On MRI, the posterior shift of the spinal cord at C4-5 was significantly greater in group P, than in group C (p < 0.01). This study is the first to correlate impairment of the C5 nerve root with a C5 palsy. It may be that early foraminotomy in susceptible individuals and the avoidance of tethering of the cord by excessive laminoplasty may prevent a post-operative palsy of the C5 nerve root. ©2010 British Editorial Society of Bone and Joint Surgery.
Ichikawa S.,Meijo Hospital
Kyobu geka. The Japanese journal of thoracic surgery | Year: 2013
A 60-year-old male was referred to our hospital due to suspected chronic heart failure. He also had a symptom of ischemic heart disease. The multi-detector row computed tomography (MDCT) demonstrated the coronary-pulmonary artery fistula with a giant coronary aneurysm, which was partly thrombosed. Two abnormal arteries to the aneurysm and the outflow to the pulmonary artery were clearly detected. Intraoperative epicardial echocardiography revealed the complete interruption of blood flow and the thrombus formation in the coronary aneurysm, that was achieved just by ligation of 2 arteries under off-pump surgery. Generally, congenital coronary-pulmonary artery fistula has complex morphological variations. In this case, MDCT and epicardial echocardiography were useful for the surgical decision-making to avoid the residual and/or the recurrent fistula.
Nathan S.T.,Leatherman |
Puno R.M.,Leatherman |
Paiso J.M.S.,Asian Hospital and Medical Center |
Kawakami N.,Meijo Hospital
Spine Journal | Year: 2011
Background context: Spinal deformities associated with spinal dysraphism are a challenging problem. Myelomeningocele has been reported in the lumbar spine. However, it is rare in the thoracic spine. Purpose: The purpose of the report was to heighten the awareness of the rare presentation of the myelomeningocele in the thoracic spine and the ability to correct the scoliosis without debulking the lesion. Study design: This is a clinical case report and literature review. Methods: We report a 13-year-old girl presented with complaints of back pain, difficulty in breathing, and easy fatigability. On examination, she had a thoracolumbar scoliosis, weakness of the right ankle dorsiflexors, and impaired sensation over the L5 dermatome of the right lower limb. Radiographic examination revealed a 128° thoracolumbar scoliosis with congenital hemivertebra at T6-T9, block vertebrae of T4 and T5, and intrathoracic myelomeningocele. She underwent an anterior closing wedge osteotomy and posterior correction of scoliosis without removal of the sac. Results: Four-year postoperative follow-up is uneventful. To date, our patient is the first patient who had scoliosis correction surgery for the rare presentation of a myelomeningocele in the thoracic spine without removal of the sac. Conclusions: To the best of our knowledge, this is the only case of anterior thoracic myelomeningocele with scoliosis in the literature who had undergone a surgical correction of the scoliosis with osteotomy without removal of the sac. Although rare, these curves are well amenable to surgical correction of scoliosis, thereby improving endurance and functional lung capacity. © 2011 Elsevier Inc.